TY - JOUR
T1 - A concise update on the status of liver transplantation for hepatitis B virus
T2 - The challenges in 2002
AU - Vargas, Hugo E.
AU - Dodson, Forrest S.
AU - Rakela, Jorge
PY - 2002
Y1 - 2002
N2 - Significant improvements in both patient and graft survival after orthotopic liver transplantation (OLT) for hepatitis B virus (HBV)-related liver failure have been made during the last decade. Recurrence of HBV infection has decreased, even in high-risk patients. Despite ongoing progress, challenges remain for the next millennium, including the determination of cost-effective dosing strategies, treatment of HBV infection in liver transplant recipients, and ramifications of the use of new antiviral agents, specifically, the appearance of resistant strains. This review summarizes the relevant history of OLT for chronic viral hepatitis B, details accepted preventive and therapeutic treatments, and discusses ongoing experimental trials. Emphasis also is placed on new approaches in transplantation as they impact on the care of HBV-infected patients.
AB - Significant improvements in both patient and graft survival after orthotopic liver transplantation (OLT) for hepatitis B virus (HBV)-related liver failure have been made during the last decade. Recurrence of HBV infection has decreased, even in high-risk patients. Despite ongoing progress, challenges remain for the next millennium, including the determination of cost-effective dosing strategies, treatment of HBV infection in liver transplant recipients, and ramifications of the use of new antiviral agents, specifically, the appearance of resistant strains. This review summarizes the relevant history of OLT for chronic viral hepatitis B, details accepted preventive and therapeutic treatments, and discusses ongoing experimental trials. Emphasis also is placed on new approaches in transplantation as they impact on the care of HBV-infected patients.
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U2 - 10.1053/jlts.2002.29765
DO - 10.1053/jlts.2002.29765
M3 - Article
C2 - 11799479
AN - SCOPUS:0036149668
SN - 1527-6465
VL - 8
SP - 2
EP - 9
JO - Liver Transplantation
JF - Liver Transplantation
IS - 1
ER -