@article{2447032456704f91b0a3a45d38915fb2,
title = "A Concise Review of Neurologic Complications Associated with Chimeric Antigen Receptor T-cell Immunotherapy",
abstract = "Chimeric antigen receptor–engineered T (CAR-T) cell immunotherapy has been successful in treating many types of hematological malignancies. CAR-T therapy, however, has been associated with toxicities, including cytokine release syndrome (CRS) as well as immune effector cell–associated neurotoxicity syndrome (ICANS). ICANS presentation is variable, largely reversible, and manifests with encephalopathy and focal neurologic deficits. Treatment strategies largely are supportive. ICANS pathophysiology likely is related to that of CRS. Preclinical studies and clinical experience have shed light on the driving forces of ICANS and have yielded new strategies to mitigate ICANS occurrence.",
keywords = "Axicabtagene ciloleucel, CAR-T, Chimeric antigen receptor, Neurotoxicity, Tisagenlecleucel",
author = "Ruff, {Michael W.} and Siegler, {Elizabeth L.} and Kenderian, {Saad S.}",
note = "Funding Information: S.S. Kenderian is an inventor on patents in the field of CAR immunotherapy that are licensed to Novartis (through an agreement between Mayo Clinic, University of Pennsylvania, and Novartis), Humanigen (through Mayo Clinic), and Mettaforge (through Mayo Clinic). S.S. Kenderian receives research funding from Kite , Gilead , Juno , Celgene , Novartis , Humanigen , MorphoSys , Tolero , Sunesis , and Lentigen . S.S. Kenderian has participated in advisory boards with Humanigen, Kite, and Juno. Funding Information: S.S. Kenderian is an inventor on patents in the field of CAR immunotherapy that are licensed to Novartis (through an agreement between Mayo Clinic, University of Pennsylvania, and Novartis), Humanigen (through Mayo Clinic), and Mettaforge (through Mayo Clinic). S.S. Kenderian receives research funding from Kite, Gilead, Juno, Celgene, Novartis, Humanigen, MorphoSys, Tolero, Sunesis, and Lentigen. S.S. Kenderian has participated in advisory boards with Humanigen, Kite, and Juno. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = nov,
doi = "10.1016/j.ncl.2020.08.001",
language = "English (US)",
volume = "38",
pages = "953--963",
journal = "Neurologic Clinics",
issn = "0733-8619",
publisher = "W.B. Saunders Ltd",
number = "4",
}