A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease

Frank Jessen; Rebecca E. Amariglio; Martin Van Boxtel; Monique Breteler; Mathieu Ceccaldi; Gaël Chételat; Bruno Dubois; Carole Dufouil; Kathryn A. Ellis; Wiesje M. Van Der Flier; Lidia Glodzik; Argonde C. Van Harten; Mony J. De Leon; Pauline McHugh; Michelle M. Mielke; Jose Luis Molinuevo; Lisa Mosconi; Ricardo S. Osorio; Audrey Perrotin; Ronald C. Petersen; Laura A. Rabin; Lorena Rami; Barry Reisberg; Dorene M. Rentz; Perminder S. Sachdev; Vincent De La Sayette; Andrew J. Saykin; Philip Scheltens; Melanie B. Shulman; Melissa J. Slavin; Reisa A. Sperling; Robert Stewart; Olga Uspenskaya; Bruno Vellas; Pieter Jelle Visser; Michael Wagner

doi:10.1016/j.jalz.2014.01.001

A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease

Frank Jessen, Rebecca E. Amariglio, Martin Van Boxtel, Monique Breteler, Mathieu Ceccaldi, Gaël Chételat, Bruno Dubois, Carole Dufouil, Kathryn A. Ellis, Wiesje M. Van Der Flier, Lidia Glodzik, Argonde C. Van Harten, Mony J. De Leon, Pauline McHugh, Michelle M. Mielke, Jose Luis Molinuevo, Lisa Mosconi, Ricardo S. Osorio, Audrey Perrotin, Ronald C. PetersenLaura A. Rabin, Lorena Rami, Barry Reisberg, Dorene M. Rentz, Perminder S. Sachdev, Vincent De La Sayette, Andrew J. Saykin, Philip Scheltens, Melanie B. Shulman, Melissa J. Slavin, Reisa A. Sperling, Robert Stewart, Olga Uspenskaya, Bruno Vellas, Pieter Jelle Visser, Michael Wagner

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939 Scopus citations

Abstract

There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer's disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD plus.

Original language	English (US)
Pages (from-to)	844-852
Number of pages	9
Journal	Alzheimer's and Dementia
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/j.jalz.2014.01.001
State	Published - Nov 1 2014

Keywords

Alzheimer's disease
Mild cognitive impairment
Preclinical Alzheimer's disease
Prodromal Alzheimer 's disease
Research criteria
Subjective cognitive decline

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1016/j.jalz.2014.01.001

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Jessen, F., Amariglio, R. E., Van Boxtel, M., Breteler, M., Ceccaldi, M., Chételat, G., Dubois, B., Dufouil, C., Ellis, K. A., Van Der Flier, W. M., Glodzik, L., Van Harten, A. C., De Leon, M. J., McHugh, P., Mielke, M. M., Molinuevo, J. L., Mosconi, L., Osorio, R. S., Perrotin, A., ... Wagner, M. (2014). A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimer's and Dementia, 10(6), 844-852. https://doi.org/10.1016/j.jalz.2014.01.001

Jessen, F, Amariglio, RE, Van Boxtel, M, Breteler, M, Ceccaldi, M, Chételat, G, Dubois, B, Dufouil, C, Ellis, KA, Van Der Flier, WM, Glodzik, L, Van Harten, AC, De Leon, MJ, McHugh, P, Mielke, MM, Molinuevo, JL, Mosconi, L, Osorio, RS, Perrotin, A, Petersen, RC, Rabin, LA, Rami, L, Reisberg, B, Rentz, DM, Sachdev, PS, De La Sayette, V, Saykin, AJ, Scheltens, P, Shulman, MB, Slavin, MJ, Sperling, RA, Stewart, R, Uspenskaya, O, Vellas, B, Visser, PJ & Wagner, M 2014, 'A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease', Alzheimer's and Dementia, vol. 10, no. 6, pp. 844-852. https://doi.org/10.1016/j.jalz.2014.01.001

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title = "A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease",

abstract = "There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer's disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD plus.",

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AU - Ceccaldi, Mathieu

AU - Chételat, Gaël

AU - Dubois, Bruno

AU - Dufouil, Carole

AU - Ellis, Kathryn A.

AU - Van Der Flier, Wiesje M.

AU - Glodzik, Lidia

AU - Van Harten, Argonde C.

AU - De Leon, Mony J.

AU - McHugh, Pauline

AU - Mielke, Michelle M.

AU - Molinuevo, Jose Luis

AU - Mosconi, Lisa

AU - Osorio, Ricardo S.

AU - Perrotin, Audrey

AU - Petersen, Ronald C.

AU - Rabin, Laura A.

AU - Rami, Lorena

AU - Reisberg, Barry

AU - Rentz, Dorene M.

AU - Sachdev, Perminder S.

AU - De La Sayette, Vincent

AU - Saykin, Andrew J.

AU - Scheltens, Philip

AU - Shulman, Melanie B.

AU - Slavin, Melissa J.

AU - Sperling, Reisa A.

AU - Stewart, Robert

AU - Uspenskaya, Olga

AU - Vellas, Bruno

AU - Visser, Pieter Jelle

AU - Wagner, Michael

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A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease

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