TY - JOUR
T1 - A comprehensive overview of tumour deposits in colorectal cancer
T2 - Towards a next TNM classification
AU - Delattre, Jean François
AU - Selcen Oguz Erdogan, Ayse
AU - Cohen, Romain
AU - Shi, Qian
AU - Emile, Jean François
AU - Taieb, Julien
AU - Tabernero, Josep
AU - André, Thierry
AU - Meyerhardt, Jeffrey A.
AU - Nagtegaal, Iris D.
AU - Svrcek, Magali
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2022/2
Y1 - 2022/2
N2 - The management of colorectal cancer (CRC) highly relies on the TNM staging system. Tumour deposits (TDs), important histoprognostic factors, are detected in approximately 20% of CRCs and associated with poor prognosis. Integration of TDs in the TNM staging remains a subject of lively debate and differs over the successive TNM classifications. Currently TDs, whatever their number, are considered in pathologic staging only in the absence of lymph node metastasis (LNM; subcategory pN1c). However, the medical community is divided over this way of integrating TDs in the TNM staging system. Considering the personalization of the type and duration of adjuvant chemotherapy in stage III colon cancer according to the number of LNM, this issue has become of growing importance. Thus, ignoring TDs in the presence of LNM represents a major prognostic underestimation and leads to wrong therapeutic decisions. Hence, considering the growing significance of prognostic role, the scientific complexity, and a potential therapeutic effect of TDs, we provide an overview of current knowledge about TDs. Based on the results from recent publications, we also provide plausible scenarios of integration of TDs into the next TNM classification system.
AB - The management of colorectal cancer (CRC) highly relies on the TNM staging system. Tumour deposits (TDs), important histoprognostic factors, are detected in approximately 20% of CRCs and associated with poor prognosis. Integration of TDs in the TNM staging remains a subject of lively debate and differs over the successive TNM classifications. Currently TDs, whatever their number, are considered in pathologic staging only in the absence of lymph node metastasis (LNM; subcategory pN1c). However, the medical community is divided over this way of integrating TDs in the TNM staging system. Considering the personalization of the type and duration of adjuvant chemotherapy in stage III colon cancer according to the number of LNM, this issue has become of growing importance. Thus, ignoring TDs in the presence of LNM represents a major prognostic underestimation and leads to wrong therapeutic decisions. Hence, considering the growing significance of prognostic role, the scientific complexity, and a potential therapeutic effect of TDs, we provide an overview of current knowledge about TDs. Based on the results from recent publications, we also provide plausible scenarios of integration of TDs into the next TNM classification system.
KW - Colorectal cancer
KW - Extra-mural vascular invasion
KW - Histoprognostic factor
KW - Lymph node metastasis
KW - Perineural invasion
KW - TNM classification
KW - Tumour deposit
UR - http://www.scopus.com/inward/record.url?scp=85121654715&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85121654715&partnerID=8YFLogxK
U2 - 10.1016/j.ctrv.2021.102325
DO - 10.1016/j.ctrv.2021.102325
M3 - Review article
C2 - 34954486
AN - SCOPUS:85121654715
SN - 0305-7372
VL - 103
JO - Cancer Treatment Reviews
JF - Cancer Treatment Reviews
M1 - 102325
ER -