TY - JOUR
T1 - A comprehensive curated resource for follicle stimulating hormone signaling
AU - Telikicherla, Deepthi
AU - Ambekar, Aditi
AU - Palapetta, Shyam
AU - Dwivedi, Sutopa B.
AU - Raju, Rajesh
AU - Sharma, Jyoti
AU - Prasad, Ts Keshava
AU - Ramachandra, Yl
AU - Mohan, S. Sujatha
AU - Maharudraiah, Jagadeesha
AU - Mukherjee, Srabani
AU - Pandey, Akhilesh
N1 - Funding Information:
We thank the Department of Biotechnology, Government of India for research support to the Institute of Bioinformatics. Deepthi Telikicherla is a recipient of a Senior Research Fellowship from Indian Council of Medical Research, Government of India. Shyam Mohan Palapetta, Rajesh Raju, Sutopa B. Dwivedi and Jyoti Sharma are recipients of a Senior Research Fellowship from the Council of Scientific and Industrial Research (CSIR), Government of India. Aditi Ambekar is a recipient of Junior Research Fellowship from the Board of Research in Nuclear Sciences, Department of Atomic Energy (DAE-BRNS), Government of India. T.S. Keshava Prasad is a recipient of a Young Investigator award from DBT.
PY - 2011
Y1 - 2011
N2 - Background: Follicle stimulating hormone (FSH) is an important hormone responsible for growth, maturation and function of the human reproductive system. FSH regulates the synthesis of steroid hormones such as estrogen and progesterone, proliferation and maturation of follicles in the ovary and spermatogenesis in the testes. FSH is a glycoprotein heterodimer that binds and acts through the FSH receptor, a G-protein coupled receptor. Although online pathway repositories provide information about G-protein coupled receptor mediated signal transduction, the signaling events initiated specifically by FSH are not cataloged in any public database in a detailed fashion. Findings. We performed comprehensive curation of the published literature to identify the components of FSH signaling pathway and the molecular interactions that occur upon FSH receptor activation. Our effort yielded 64 reactions comprising 35 enzyme-substrate reactions, 11 molecular association events, 11 activation events and 7 protein translocation events that occur in response to FSH receptor activation. We also cataloged 265 genes, which were differentially expressed upon FSH stimulation in normal human reproductive tissues. Conclusions: We anticipate that the information provided in this resource will provide better insights into the physiological role of FSH in reproductive biology, its signaling mediators and aid in further research in this area. The curated FSH pathway data is freely available through NetPath (http://www.netpath.org), a pathway resource developed previously by our group.
AB - Background: Follicle stimulating hormone (FSH) is an important hormone responsible for growth, maturation and function of the human reproductive system. FSH regulates the synthesis of steroid hormones such as estrogen and progesterone, proliferation and maturation of follicles in the ovary and spermatogenesis in the testes. FSH is a glycoprotein heterodimer that binds and acts through the FSH receptor, a G-protein coupled receptor. Although online pathway repositories provide information about G-protein coupled receptor mediated signal transduction, the signaling events initiated specifically by FSH are not cataloged in any public database in a detailed fashion. Findings. We performed comprehensive curation of the published literature to identify the components of FSH signaling pathway and the molecular interactions that occur upon FSH receptor activation. Our effort yielded 64 reactions comprising 35 enzyme-substrate reactions, 11 molecular association events, 11 activation events and 7 protein translocation events that occur in response to FSH receptor activation. We also cataloged 265 genes, which were differentially expressed upon FSH stimulation in normal human reproductive tissues. Conclusions: We anticipate that the information provided in this resource will provide better insights into the physiological role of FSH in reproductive biology, its signaling mediators and aid in further research in this area. The curated FSH pathway data is freely available through NetPath (http://www.netpath.org), a pathway resource developed previously by our group.
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U2 - 10.1186/1756-0500-4-408
DO - 10.1186/1756-0500-4-408
M3 - Article
C2 - 21996254
AN - SCOPUS:80053917955
SN - 1756-0500
VL - 4
JO - BMC Research Notes
JF - BMC Research Notes
M1 - 408
ER -