A Comprehensive Curated Reaction Map of Leptin Signaling Pathway

Vishalakshi Nanjappa, Rajesh Raju, Babylakshmi Muthusamy, Jyoti Sharma, Joji Kurian Thomas, Pachakkil A.H. Haridas Nidhina, H. C. Harsha, Akhilesh Pandey, Gopalakrishnapillai Anilkumar, T. S. Keshava Prasad

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Leptin, a peptide hormone, regulates endocrine function and maintains body weight homeostasis by regulating food intake and energy expenditure via hypothalamus-mediated effects. Impairment in leptin signaling induces obesity, a major health problem worldwide. Leptin signaling regulates other physiological processes such as angiogenesis, hematopoiesis and also has effects on the reproductive, cardiovascular and immune systems. Despite its biomedical importance, a comprehensive catalog of the signaling events activated by leptin is not available as a public resource. Therefore, we initiated cataloging of the molecular reactions in this pathway to develop a detailed reaction map of leptin signaling. For the benefit of scientific community, we provided the leptin signaling pathway through NetPath (http://www.netpath.org), a freely accessible pathway resource previously developed by our group. We anticipate that leptin/leptin receptor signaling map and the data comprising these signaling events will enable future biomedical investigations.

Original languageEnglish (US)
Pages (from-to)184-189
Number of pages6
JournalJournal of Proteomics and Bioinformatics
Volume4
Issue number9
DOIs
StatePublished - Sep 1 2011

Keywords

  • Adipocyte
  • Cytokine
  • Energy homeostasis
  • Leptin resistance
  • NetSlim
  • PathVisio

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Cell Biology

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  • Cite this

    Nanjappa, V., Raju, R., Muthusamy, B., Sharma, J., Thomas, J. K., Haridas Nidhina, P. A. H., Harsha, H. C., Pandey, A., Anilkumar, G., & Keshava Prasad, T. S. (2011). A Comprehensive Curated Reaction Map of Leptin Signaling Pathway. Journal of Proteomics and Bioinformatics, 4(9), 184-189. https://doi.org/10.4172/jpb.1000188