TY - JOUR
T1 - A Comprehensive Curated Reaction Map of Leptin Signaling Pathway
AU - Nanjappa, Vishalakshi
AU - Raju, Rajesh
AU - Muthusamy, Babylakshmi
AU - Sharma, Jyoti
AU - Thomas, Joji Kurian
AU - Haridas Nidhina, Pachakkil A.H.
AU - Harsha, H. C.
AU - Pandey, Akhilesh
AU - Anilkumar, Gopalakrishnapillai
AU - Keshava Prasad, T. S.
PY - 2011/9
Y1 - 2011/9
N2 - Leptin, a peptide hormone, regulates endocrine function and maintains body weight homeostasis by regulating food intake and energy expenditure via hypothalamus-mediated effects. Impairment in leptin signaling induces obesity, a major health problem worldwide. Leptin signaling regulates other physiological processes such as angiogenesis, hematopoiesis and also has effects on the reproductive, cardiovascular and immune systems. Despite its biomedical importance, a comprehensive catalog of the signaling events activated by leptin is not available as a public resource. Therefore, we initiated cataloging of the molecular reactions in this pathway to develop a detailed reaction map of leptin signaling. For the benefit of scientific community, we provided the leptin signaling pathway through NetPath (http://www.netpath.org), a freely accessible pathway resource previously developed by our group. We anticipate that leptin/leptin receptor signaling map and the data comprising these signaling events will enable future biomedical investigations.
AB - Leptin, a peptide hormone, regulates endocrine function and maintains body weight homeostasis by regulating food intake and energy expenditure via hypothalamus-mediated effects. Impairment in leptin signaling induces obesity, a major health problem worldwide. Leptin signaling regulates other physiological processes such as angiogenesis, hematopoiesis and also has effects on the reproductive, cardiovascular and immune systems. Despite its biomedical importance, a comprehensive catalog of the signaling events activated by leptin is not available as a public resource. Therefore, we initiated cataloging of the molecular reactions in this pathway to develop a detailed reaction map of leptin signaling. For the benefit of scientific community, we provided the leptin signaling pathway through NetPath (http://www.netpath.org), a freely accessible pathway resource previously developed by our group. We anticipate that leptin/leptin receptor signaling map and the data comprising these signaling events will enable future biomedical investigations.
KW - Adipocyte
KW - Cytokine
KW - Energy homeostasis
KW - Leptin resistance
KW - NetSlim
KW - PathVisio
UR - http://www.scopus.com/inward/record.url?scp=84861775201&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861775201&partnerID=8YFLogxK
U2 - 10.4172/jpb.1000188
DO - 10.4172/jpb.1000188
M3 - Article
AN - SCOPUS:84861775201
SN - 0974-276X
VL - 4
SP - 184
EP - 189
JO - Journal of Proteomics and Bioinformatics
JF - Journal of Proteomics and Bioinformatics
IS - 9
ER -