A comprehensive (biological and computational) investigation on the role of microRNA::mRNA regulations performed in chronic obstructive pulmonary disease and lung cancer

Jingshan Huang, Dejing Dou, Jun She, Andrew Harold Limper, Yanan D Yang, Ping Yang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are two serious diseases that present a major health problem worldwide. However, genetic contribution to both diseases remains unclear, including various regulation mechanisms at genetic level resulting in the progression from COPD to LC. In this paper, we describe our comprehensive methodologies, which seamlessly integrate both biological (conducted in 'wet labs') and computational (based on domain ontologies and semantic technologies) approaches, to investigate the important role of microRNA::mRNA regulations performed in COPD and LC. We discovered two genes, RGS6 and PARK2, that are strongly associated with the risk of developing either COPD or LC or both; additionally, we also identified two sets of microRNAs that are computationally predicted to regulate RGS6 and PARK2, respectively. These microRNAs can be further biologically verified in the future and serve as novel biomarkers in COPD and/or LC.

Original languageEnglish (US)
Title of host publicationProceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1062-1067
Number of pages6
ISBN (Electronic)9781509016105
DOIs
StatePublished - Jan 17 2017
Event2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016 - Shenzhen, China
Duration: Dec 15 2016Dec 18 2016

Other

Other2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016
CountryChina
CityShenzhen
Period12/15/1612/18/16

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Keywords

  • Bio-ontology
  • Chronic obstructive pulmonary disease
  • COPD
  • Lung cancer
  • MicroRNA
  • Semantic search
  • Target gene

ASJC Scopus subject areas

  • Genetics
  • Medicine (miscellaneous)
  • Genetics(clinical)
  • Biochemistry, medical
  • Biochemistry
  • Molecular Medicine
  • Health Informatics

Cite this

Huang, J., Dou, D., She, J., Limper, A. H., Yang, Y. D., & Yang, P. (2017). A comprehensive (biological and computational) investigation on the role of microRNA::mRNA regulations performed in chronic obstructive pulmonary disease and lung cancer. In Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016 (pp. 1062-1067). [7822669] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIBM.2016.7822669