A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome

R. J. Mural, M. D. Adams, E. W. Myers, H. O. Smith, G. L. Gabor Miklos, R. Wides, A. Halpern, P. W. Li, G. G. Sutton, J. Nadeau, S. L. Salzberg, R. A. Holt, C. D. Kodira, F. Lu, L. Chen, Z. Deng, C. C. Evangelista, W. Gan, T. J. Heiman, J. Li & 157 others Z. Li, G. V. Merkulov, N. V. Milshina, A. K. Naik, R. Qi, B. Chris Shue, A. Wang, J. Wang, X. Wang, X. Yan, J. Ye, S. Yooseph, Q. Zhao, L. Zheng, S. C. Zhu, K. Biddick, R. Bolanos, A. L. Delcher, I. M. Dew, D. Fasulo, M. J. Flanigan, D. H. Huson, S. A. Kravitz, J. R. Miller, C. M. Mobarry, K. Reinert, K. A. Remington, Q. Zhang, X. H. Zheng, D. R. Nusskern, Z. Lai, Y. Lei, W. Zhong, A. Yao, P. Guan, R. R. Ji, Z. Gu, Z. Y. Wang, F. Zhong, C. Xiao, C. C. Chiang, M. Yandell, J. R. Wortman, P. G. Amanatides, S. L. Hladun, E. C. Pratts, J. E. Johnson, K. L. Dodson, K. J. Woodford, C. A. Evans, B. Gropman, D. B. Rusch, E. Venter, M. Wang, T. J. Smith, J. T. Houck, D. E. Tompkins, C. Haynes, D. Jacob, S. H. Chin, D. R. Allen, C. E. Dahlke, R. Sanders, K. Li, X. Liu, A. A. Levitsky, W. H. Majoros, Q. Chen, A. C. Xia, J. R. Lopez, M. T. Donnelly, M. H. Newman, A. Glodek, C. L. Kraft, M. Nodell, F. Ali, H. J. An, D. Baldwin-Pitts, K. Y. Beeson, S. Cai, M. Carnes, A. Carver, P. M. Caulk, A. Center, Y. H. Chen, M. L. Cheng, M. D. Coyne, M. Crowder, S. Danaher, L. B. Davenport, R. Desilets, S. M. Dietz, L. Doup, P. Dullaghan, S. Ferriera, C. R. Fosler, H. C. Gire, A. Gluecksmann, J. D. Gocayne, J. Gray, B. Hart, J. Haynes, J. Hoover, T. Howland, C. Ibegwam, M. Jalali, D. Johns, L. Kline, D. S. Ma, S. MacCawley, A. Magoon, F. Mann, D. May, T. C. McIntosh, S. Mehta, L. Moy, M. C. Moy, B. J. Murphy, S. D. Murphy, K. A. Nelson, Z. Nuri, K. A. Parker, A. C. Prudhomme, V. N. Puri, H. Qureshi, J. C. Raley, M. S. Reardon, M. A. Regier, Yu H C Rogers, D. L. Romblad, J. Schutz, J. L. Scott, R. Scott, C. D. Sitter, M. Smallwood, A. C. Sprague, E. Stewart, R. V. Strong, E. Suh, K. Sylvester, R. Thomas, N. Ni Tint, C. Tsonis, G. Wang, G. Wang, M. S. Williams, S. M. Williams, S. M. Windsor, K. Wolfe, M. M. Wu, J. Zaveri, K. Chaturvedi, A. E. Gabrielian, Z. Ke, J. Sun, G. Subramanian, J. Craig Venter

Research output: Contribution to journalArticle

260 Citations (Scopus)

Abstract

The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole-genome shotgun assembly of the mouse genome. The mouse genome is about 10% smaller than the human genome, owing to a lower repetitive DNA content. Comparison of the structure and protein-coding potential of Mmu 16 with that of the homologous segments of the human genome identifies regions of conserved synteny with human chromosomes (Hsa) 3, 8, 12, 16, 21, and 22. Gene content and order are highly conserved between Mmu 16 and the syntenic blocks of the human genome. Of the 731 predicted genes on Mmu 16, 509 align with orthologs on the corresponding portions of the human genome, 44 are likely paralogous to these genes, and 164 genes have homologs elsewhere in the human genome; there are 14 genes for which we could find no human counterpart.

Original languageEnglish (US)
Pages (from-to)1661-1671
Number of pages11
JournalScience
Volume296
Issue number5573
DOIs
StatePublished - May 31 2002
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 16
Firearms
Human Genome
Genome
Genes
Synteny
Chromosomes, Human, Pair 3
Gene Order
Human Chromosomes
Sequence Analysis
DNA
Proteins

ASJC Scopus subject areas

  • General

Cite this

Mural, R. J., Adams, M. D., Myers, E. W., Smith, H. O., Gabor Miklos, G. L., Wides, R., ... Craig Venter, J. (2002). A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science, 296(5573), 1661-1671. https://doi.org/10.1126/science.1069193

A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. / Mural, R. J.; Adams, M. D.; Myers, E. W.; Smith, H. O.; Gabor Miklos, G. L.; Wides, R.; Halpern, A.; Li, P. W.; Sutton, G. G.; Nadeau, J.; Salzberg, S. L.; Holt, R. A.; Kodira, C. D.; Lu, F.; Chen, L.; Deng, Z.; Evangelista, C. C.; Gan, W.; Heiman, T. J.; Li, J.; Li, Z.; Merkulov, G. V.; Milshina, N. V.; Naik, A. K.; Qi, R.; Chris Shue, B.; Wang, A.; Wang, J.; Wang, X.; Yan, X.; Ye, J.; Yooseph, S.; Zhao, Q.; Zheng, L.; Zhu, S. C.; Biddick, K.; Bolanos, R.; Delcher, A. L.; Dew, I. M.; Fasulo, D.; Flanigan, M. J.; Huson, D. H.; Kravitz, S. A.; Miller, J. R.; Mobarry, C. M.; Reinert, K.; Remington, K. A.; Zhang, Q.; Zheng, X. H.; Nusskern, D. R.; Lai, Z.; Lei, Y.; Zhong, W.; Yao, A.; Guan, P.; Ji, R. R.; Gu, Z.; Wang, Z. Y.; Zhong, F.; Xiao, C.; Chiang, C. C.; Yandell, M.; Wortman, J. R.; Amanatides, P. G.; Hladun, S. L.; Pratts, E. C.; Johnson, J. E.; Dodson, K. L.; Woodford, K. J.; Evans, C. A.; Gropman, B.; Rusch, D. B.; Venter, E.; Wang, M.; Smith, T. J.; Houck, J. T.; Tompkins, D. E.; Haynes, C.; Jacob, D.; Chin, S. H.; Allen, D. R.; Dahlke, C. E.; Sanders, R.; Li, K.; Liu, X.; Levitsky, A. A.; Majoros, W. H.; Chen, Q.; Xia, A. C.; Lopez, J. R.; Donnelly, M. T.; Newman, M. H.; Glodek, A.; Kraft, C. L.; Nodell, M.; Ali, F.; An, H. J.; Baldwin-Pitts, D.; Beeson, K. Y.; Cai, S.; Carnes, M.; Carver, A.; Caulk, P. M.; Center, A.; Chen, Y. H.; Cheng, M. L.; Coyne, M. D.; Crowder, M.; Danaher, S.; Davenport, L. B.; Desilets, R.; Dietz, S. M.; Doup, L.; Dullaghan, P.; Ferriera, S.; Fosler, C. R.; Gire, H. C.; Gluecksmann, A.; Gocayne, J. D.; Gray, J.; Hart, B.; Haynes, J.; Hoover, J.; Howland, T.; Ibegwam, C.; Jalali, M.; Johns, D.; Kline, L.; Ma, D. S.; MacCawley, S.; Magoon, A.; Mann, F.; May, D.; McIntosh, T. C.; Mehta, S.; Moy, L.; Moy, M. C.; Murphy, B. J.; Murphy, S. D.; Nelson, K. A.; Nuri, Z.; Parker, K. A.; Prudhomme, A. C.; Puri, V. N.; Qureshi, H.; Raley, J. C.; Reardon, M. S.; Regier, M. A.; Rogers, Yu H C; Romblad, D. L.; Schutz, J.; Scott, J. L.; Scott, R.; Sitter, C. D.; Smallwood, M.; Sprague, A. C.; Stewart, E.; Strong, R. V.; Suh, E.; Sylvester, K.; Thomas, R.; Ni Tint, N.; Tsonis, C.; Wang, G.; Wang, G.; Williams, M. S.; Williams, S. M.; Windsor, S. M.; Wolfe, K.; Wu, M. M.; Zaveri, J.; Chaturvedi, K.; Gabrielian, A. E.; Ke, Z.; Sun, J.; Subramanian, G.; Craig Venter, J.

In: Science, Vol. 296, No. 5573, 31.05.2002, p. 1661-1671.

Research output: Contribution to journalArticle

Mural, RJ, Adams, MD, Myers, EW, Smith, HO, Gabor Miklos, GL, Wides, R, Halpern, A, Li, PW, Sutton, GG, Nadeau, J, Salzberg, SL, Holt, RA, Kodira, CD, Lu, F, Chen, L, Deng, Z, Evangelista, CC, Gan, W, Heiman, TJ, Li, J, Li, Z, Merkulov, GV, Milshina, NV, Naik, AK, Qi, R, Chris Shue, B, Wang, A, Wang, J, Wang, X, Yan, X, Ye, J, Yooseph, S, Zhao, Q, Zheng, L, Zhu, SC, Biddick, K, Bolanos, R, Delcher, AL, Dew, IM, Fasulo, D, Flanigan, MJ, Huson, DH, Kravitz, SA, Miller, JR, Mobarry, CM, Reinert, K, Remington, KA, Zhang, Q, Zheng, XH, Nusskern, DR, Lai, Z, Lei, Y, Zhong, W, Yao, A, Guan, P, Ji, RR, Gu, Z, Wang, ZY, Zhong, F, Xiao, C, Chiang, CC, Yandell, M, Wortman, JR, Amanatides, PG, Hladun, SL, Pratts, EC, Johnson, JE, Dodson, KL, Woodford, KJ, Evans, CA, Gropman, B, Rusch, DB, Venter, E, Wang, M, Smith, TJ, Houck, JT, Tompkins, DE, Haynes, C, Jacob, D, Chin, SH, Allen, DR, Dahlke, CE, Sanders, R, Li, K, Liu, X, Levitsky, AA, Majoros, WH, Chen, Q, Xia, AC, Lopez, JR, Donnelly, MT, Newman, MH, Glodek, A, Kraft, CL, Nodell, M, Ali, F, An, HJ, Baldwin-Pitts, D, Beeson, KY, Cai, S, Carnes, M, Carver, A, Caulk, PM, Center, A, Chen, YH, Cheng, ML, Coyne, MD, Crowder, M, Danaher, S, Davenport, LB, Desilets, R, Dietz, SM, Doup, L, Dullaghan, P, Ferriera, S, Fosler, CR, Gire, HC, Gluecksmann, A, Gocayne, JD, Gray, J, Hart, B, Haynes, J, Hoover, J, Howland, T, Ibegwam, C, Jalali, M, Johns, D, Kline, L, Ma, DS, MacCawley, S, Magoon, A, Mann, F, May, D, McIntosh, TC, Mehta, S, Moy, L, Moy, MC, Murphy, BJ, Murphy, SD, Nelson, KA, Nuri, Z, Parker, KA, Prudhomme, AC, Puri, VN, Qureshi, H, Raley, JC, Reardon, MS, Regier, MA, Rogers, YHC, Romblad, DL, Schutz, J, Scott, JL, Scott, R, Sitter, CD, Smallwood, M, Sprague, AC, Stewart, E, Strong, RV, Suh, E, Sylvester, K, Thomas, R, Ni Tint, N, Tsonis, C, Wang, G, Wang, G, Williams, MS, Williams, SM, Windsor, SM, Wolfe, K, Wu, MM, Zaveri, J, Chaturvedi, K, Gabrielian, AE, Ke, Z, Sun, J, Subramanian, G & Craig Venter, J 2002, 'A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome' Science, vol. 296, no. 5573, pp. 1661-1671. https://doi.org/10.1126/science.1069193
Mural RJ, Adams MD, Myers EW, Smith HO, Gabor Miklos GL, Wides R et al. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science. 2002 May 31;296(5573):1661-1671. https://doi.org/10.1126/science.1069193
Mural, R. J. ; Adams, M. D. ; Myers, E. W. ; Smith, H. O. ; Gabor Miklos, G. L. ; Wides, R. ; Halpern, A. ; Li, P. W. ; Sutton, G. G. ; Nadeau, J. ; Salzberg, S. L. ; Holt, R. A. ; Kodira, C. D. ; Lu, F. ; Chen, L. ; Deng, Z. ; Evangelista, C. C. ; Gan, W. ; Heiman, T. J. ; Li, J. ; Li, Z. ; Merkulov, G. V. ; Milshina, N. V. ; Naik, A. K. ; Qi, R. ; Chris Shue, B. ; Wang, A. ; Wang, J. ; Wang, X. ; Yan, X. ; Ye, J. ; Yooseph, S. ; Zhao, Q. ; Zheng, L. ; Zhu, S. C. ; Biddick, K. ; Bolanos, R. ; Delcher, A. L. ; Dew, I. M. ; Fasulo, D. ; Flanigan, M. J. ; Huson, D. H. ; Kravitz, S. A. ; Miller, J. R. ; Mobarry, C. M. ; Reinert, K. ; Remington, K. A. ; Zhang, Q. ; Zheng, X. H. ; Nusskern, D. R. ; Lai, Z. ; Lei, Y. ; Zhong, W. ; Yao, A. ; Guan, P. ; Ji, R. R. ; Gu, Z. ; Wang, Z. Y. ; Zhong, F. ; Xiao, C. ; Chiang, C. C. ; Yandell, M. ; Wortman, J. R. ; Amanatides, P. G. ; Hladun, S. L. ; Pratts, E. C. ; Johnson, J. E. ; Dodson, K. L. ; Woodford, K. J. ; Evans, C. A. ; Gropman, B. ; Rusch, D. B. ; Venter, E. ; Wang, M. ; Smith, T. J. ; Houck, J. T. ; Tompkins, D. E. ; Haynes, C. ; Jacob, D. ; Chin, S. H. ; Allen, D. R. ; Dahlke, C. E. ; Sanders, R. ; Li, K. ; Liu, X. ; Levitsky, A. A. ; Majoros, W. H. ; Chen, Q. ; Xia, A. C. ; Lopez, J. R. ; Donnelly, M. T. ; Newman, M. H. ; Glodek, A. ; Kraft, C. L. ; Nodell, M. ; Ali, F. ; An, H. J. ; Baldwin-Pitts, D. ; Beeson, K. Y. ; Cai, S. ; Carnes, M. ; Carver, A. ; Caulk, P. M. ; Center, A. ; Chen, Y. H. ; Cheng, M. L. ; Coyne, M. D. ; Crowder, M. ; Danaher, S. ; Davenport, L. B. ; Desilets, R. ; Dietz, S. M. ; Doup, L. ; Dullaghan, P. ; Ferriera, S. ; Fosler, C. R. ; Gire, H. C. ; Gluecksmann, A. ; Gocayne, J. D. ; Gray, J. ; Hart, B. ; Haynes, J. ; Hoover, J. ; Howland, T. ; Ibegwam, C. ; Jalali, M. ; Johns, D. ; Kline, L. ; Ma, D. S. ; MacCawley, S. ; Magoon, A. ; Mann, F. ; May, D. ; McIntosh, T. C. ; Mehta, S. ; Moy, L. ; Moy, M. C. ; Murphy, B. J. ; Murphy, S. D. ; Nelson, K. A. ; Nuri, Z. ; Parker, K. A. ; Prudhomme, A. C. ; Puri, V. N. ; Qureshi, H. ; Raley, J. C. ; Reardon, M. S. ; Regier, M. A. ; Rogers, Yu H C ; Romblad, D. L. ; Schutz, J. ; Scott, J. L. ; Scott, R. ; Sitter, C. D. ; Smallwood, M. ; Sprague, A. C. ; Stewart, E. ; Strong, R. V. ; Suh, E. ; Sylvester, K. ; Thomas, R. ; Ni Tint, N. ; Tsonis, C. ; Wang, G. ; Wang, G. ; Williams, M. S. ; Williams, S. M. ; Windsor, S. M. ; Wolfe, K. ; Wu, M. M. ; Zaveri, J. ; Chaturvedi, K. ; Gabrielian, A. E. ; Ke, Z. ; Sun, J. ; Subramanian, G. ; Craig Venter, J. / A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. In: Science. 2002 ; Vol. 296, No. 5573. pp. 1661-1671.
@article{c916e793a7c94f42ae35a933b17b3783,
title = "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome",
abstract = "The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole-genome shotgun assembly of the mouse genome. The mouse genome is about 10{\%} smaller than the human genome, owing to a lower repetitive DNA content. Comparison of the structure and protein-coding potential of Mmu 16 with that of the homologous segments of the human genome identifies regions of conserved synteny with human chromosomes (Hsa) 3, 8, 12, 16, 21, and 22. Gene content and order are highly conserved between Mmu 16 and the syntenic blocks of the human genome. Of the 731 predicted genes on Mmu 16, 509 align with orthologs on the corresponding portions of the human genome, 44 are likely paralogous to these genes, and 164 genes have homologs elsewhere in the human genome; there are 14 genes for which we could find no human counterpart.",
author = "Mural, {R. J.} and Adams, {M. D.} and Myers, {E. W.} and Smith, {H. O.} and {Gabor Miklos}, {G. L.} and R. Wides and A. Halpern and Li, {P. W.} and Sutton, {G. G.} and J. Nadeau and Salzberg, {S. L.} and Holt, {R. A.} and Kodira, {C. D.} and F. Lu and L. Chen and Z. Deng and Evangelista, {C. C.} and W. Gan and Heiman, {T. J.} and J. Li and Z. Li and Merkulov, {G. V.} and Milshina, {N. V.} and Naik, {A. K.} and R. Qi and {Chris Shue}, B. and A. Wang and J. Wang and X. Wang and X. Yan and J. Ye and S. Yooseph and Q. Zhao and L. Zheng and Zhu, {S. C.} and K. Biddick and R. Bolanos and Delcher, {A. L.} and Dew, {I. M.} and D. Fasulo and Flanigan, {M. J.} and Huson, {D. H.} and Kravitz, {S. A.} and Miller, {J. R.} and Mobarry, {C. M.} and K. Reinert and Remington, {K. A.} and Q. Zhang and Zheng, {X. H.} and Nusskern, {D. R.} and Z. Lai and Y. Lei and W. Zhong and A. Yao and P. Guan and Ji, {R. R.} and Z. Gu and Wang, {Z. Y.} and F. Zhong and C. Xiao and Chiang, {C. C.} and M. Yandell and Wortman, {J. R.} and Amanatides, {P. G.} and Hladun, {S. L.} and Pratts, {E. C.} and Johnson, {J. E.} and Dodson, {K. L.} and Woodford, {K. J.} and Evans, {C. A.} and B. Gropman and Rusch, {D. B.} and E. Venter and M. Wang and Smith, {T. J.} and Houck, {J. T.} and Tompkins, {D. E.} and C. Haynes and D. Jacob and Chin, {S. H.} and Allen, {D. R.} and Dahlke, {C. E.} and R. Sanders and K. Li and X. Liu and Levitsky, {A. A.} and Majoros, {W. H.} and Q. Chen and Xia, {A. C.} and Lopez, {J. R.} and Donnelly, {M. T.} and Newman, {M. H.} and A. Glodek and Kraft, {C. L.} and M. Nodell and F. Ali and An, {H. J.} and D. Baldwin-Pitts and Beeson, {K. Y.} and S. Cai and M. Carnes and A. Carver and Caulk, {P. M.} and A. Center and Chen, {Y. H.} and Cheng, {M. L.} and Coyne, {M. D.} and M. Crowder and S. Danaher and Davenport, {L. B.} and R. Desilets and Dietz, {S. M.} and L. Doup and P. Dullaghan and S. Ferriera and Fosler, {C. R.} and Gire, {H. C.} and A. Gluecksmann and Gocayne, {J. D.} and J. Gray and B. Hart and J. Haynes and J. Hoover and T. Howland and C. Ibegwam and M. Jalali and D. Johns and L. Kline and Ma, {D. S.} and S. MacCawley and A. Magoon and F. Mann and D. May and McIntosh, {T. C.} and S. Mehta and L. Moy and Moy, {M. C.} and Murphy, {B. J.} and Murphy, {S. D.} and Nelson, {K. A.} and Z. Nuri and Parker, {K. A.} and Prudhomme, {A. C.} and Puri, {V. N.} and H. Qureshi and Raley, {J. C.} and Reardon, {M. S.} and Regier, {M. A.} and Rogers, {Yu H C} and Romblad, {D. L.} and J. Schutz and Scott, {J. L.} and R. Scott and Sitter, {C. D.} and M. Smallwood and Sprague, {A. C.} and E. Stewart and Strong, {R. V.} and E. Suh and K. Sylvester and R. Thomas and {Ni Tint}, N. and C. Tsonis and G. Wang and G. Wang and Williams, {M. S.} and Williams, {S. M.} and Windsor, {S. M.} and K. Wolfe and Wu, {M. M.} and J. Zaveri and K. Chaturvedi and Gabrielian, {A. E.} and Z. Ke and J. Sun and G. Subramanian and {Craig Venter}, J.",
year = "2002",
month = "5",
day = "31",
doi = "10.1126/science.1069193",
language = "English (US)",
volume = "296",
pages = "1661--1671",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5573",

}

TY - JOUR

T1 - A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome

AU - Mural, R. J.

AU - Adams, M. D.

AU - Myers, E. W.

AU - Smith, H. O.

AU - Gabor Miklos, G. L.

AU - Wides, R.

AU - Halpern, A.

AU - Li, P. W.

AU - Sutton, G. G.

AU - Nadeau, J.

AU - Salzberg, S. L.

AU - Holt, R. A.

AU - Kodira, C. D.

AU - Lu, F.

AU - Chen, L.

AU - Deng, Z.

AU - Evangelista, C. C.

AU - Gan, W.

AU - Heiman, T. J.

AU - Li, J.

AU - Li, Z.

AU - Merkulov, G. V.

AU - Milshina, N. V.

AU - Naik, A. K.

AU - Qi, R.

AU - Chris Shue, B.

AU - Wang, A.

AU - Wang, J.

AU - Wang, X.

AU - Yan, X.

AU - Ye, J.

AU - Yooseph, S.

AU - Zhao, Q.

AU - Zheng, L.

AU - Zhu, S. C.

AU - Biddick, K.

AU - Bolanos, R.

AU - Delcher, A. L.

AU - Dew, I. M.

AU - Fasulo, D.

AU - Flanigan, M. J.

AU - Huson, D. H.

AU - Kravitz, S. A.

AU - Miller, J. R.

AU - Mobarry, C. M.

AU - Reinert, K.

AU - Remington, K. A.

AU - Zhang, Q.

AU - Zheng, X. H.

AU - Nusskern, D. R.

AU - Lai, Z.

AU - Lei, Y.

AU - Zhong, W.

AU - Yao, A.

AU - Guan, P.

AU - Ji, R. R.

AU - Gu, Z.

AU - Wang, Z. Y.

AU - Zhong, F.

AU - Xiao, C.

AU - Chiang, C. C.

AU - Yandell, M.

AU - Wortman, J. R.

AU - Amanatides, P. G.

AU - Hladun, S. L.

AU - Pratts, E. C.

AU - Johnson, J. E.

AU - Dodson, K. L.

AU - Woodford, K. J.

AU - Evans, C. A.

AU - Gropman, B.

AU - Rusch, D. B.

AU - Venter, E.

AU - Wang, M.

AU - Smith, T. J.

AU - Houck, J. T.

AU - Tompkins, D. E.

AU - Haynes, C.

AU - Jacob, D.

AU - Chin, S. H.

AU - Allen, D. R.

AU - Dahlke, C. E.

AU - Sanders, R.

AU - Li, K.

AU - Liu, X.

AU - Levitsky, A. A.

AU - Majoros, W. H.

AU - Chen, Q.

AU - Xia, A. C.

AU - Lopez, J. R.

AU - Donnelly, M. T.

AU - Newman, M. H.

AU - Glodek, A.

AU - Kraft, C. L.

AU - Nodell, M.

AU - Ali, F.

AU - An, H. J.

AU - Baldwin-Pitts, D.

AU - Beeson, K. Y.

AU - Cai, S.

AU - Carnes, M.

AU - Carver, A.

AU - Caulk, P. M.

AU - Center, A.

AU - Chen, Y. H.

AU - Cheng, M. L.

AU - Coyne, M. D.

AU - Crowder, M.

AU - Danaher, S.

AU - Davenport, L. B.

AU - Desilets, R.

AU - Dietz, S. M.

AU - Doup, L.

AU - Dullaghan, P.

AU - Ferriera, S.

AU - Fosler, C. R.

AU - Gire, H. C.

AU - Gluecksmann, A.

AU - Gocayne, J. D.

AU - Gray, J.

AU - Hart, B.

AU - Haynes, J.

AU - Hoover, J.

AU - Howland, T.

AU - Ibegwam, C.

AU - Jalali, M.

AU - Johns, D.

AU - Kline, L.

AU - Ma, D. S.

AU - MacCawley, S.

AU - Magoon, A.

AU - Mann, F.

AU - May, D.

AU - McIntosh, T. C.

AU - Mehta, S.

AU - Moy, L.

AU - Moy, M. C.

AU - Murphy, B. J.

AU - Murphy, S. D.

AU - Nelson, K. A.

AU - Nuri, Z.

AU - Parker, K. A.

AU - Prudhomme, A. C.

AU - Puri, V. N.

AU - Qureshi, H.

AU - Raley, J. C.

AU - Reardon, M. S.

AU - Regier, M. A.

AU - Rogers, Yu H C

AU - Romblad, D. L.

AU - Schutz, J.

AU - Scott, J. L.

AU - Scott, R.

AU - Sitter, C. D.

AU - Smallwood, M.

AU - Sprague, A. C.

AU - Stewart, E.

AU - Strong, R. V.

AU - Suh, E.

AU - Sylvester, K.

AU - Thomas, R.

AU - Ni Tint, N.

AU - Tsonis, C.

AU - Wang, G.

AU - Wang, G.

AU - Williams, M. S.

AU - Williams, S. M.

AU - Windsor, S. M.

AU - Wolfe, K.

AU - Wu, M. M.

AU - Zaveri, J.

AU - Chaturvedi, K.

AU - Gabrielian, A. E.

AU - Ke, Z.

AU - Sun, J.

AU - Subramanian, G.

AU - Craig Venter, J.

PY - 2002/5/31

Y1 - 2002/5/31

N2 - The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole-genome shotgun assembly of the mouse genome. The mouse genome is about 10% smaller than the human genome, owing to a lower repetitive DNA content. Comparison of the structure and protein-coding potential of Mmu 16 with that of the homologous segments of the human genome identifies regions of conserved synteny with human chromosomes (Hsa) 3, 8, 12, 16, 21, and 22. Gene content and order are highly conserved between Mmu 16 and the syntenic blocks of the human genome. Of the 731 predicted genes on Mmu 16, 509 align with orthologs on the corresponding portions of the human genome, 44 are likely paralogous to these genes, and 164 genes have homologs elsewhere in the human genome; there are 14 genes for which we could find no human counterpart.

AB - The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole-genome shotgun assembly of the mouse genome. The mouse genome is about 10% smaller than the human genome, owing to a lower repetitive DNA content. Comparison of the structure and protein-coding potential of Mmu 16 with that of the homologous segments of the human genome identifies regions of conserved synteny with human chromosomes (Hsa) 3, 8, 12, 16, 21, and 22. Gene content and order are highly conserved between Mmu 16 and the syntenic blocks of the human genome. Of the 731 predicted genes on Mmu 16, 509 align with orthologs on the corresponding portions of the human genome, 44 are likely paralogous to these genes, and 164 genes have homologs elsewhere in the human genome; there are 14 genes for which we could find no human counterpart.

UR - http://www.scopus.com/inward/record.url?scp=0037204994&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037204994&partnerID=8YFLogxK

U2 - 10.1126/science.1069193

DO - 10.1126/science.1069193

M3 - Article

VL - 296

SP - 1661

EP - 1671

JO - Science

JF - Science

SN - 0036-8075

IS - 5573

ER -