A comparison of ultrasound and magnetic resonance imaging shows that kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease

Harpreet Bhutani, Vikram Smith, Frederic Rahbari-Oskoui, Ankush Mittal, Jared J. Grantham, Vicente Torres, Michal Mrug, Kyongtae T. Bae, Zhiyuan Wu, Yinghui Ge, Doug Landslittel, Patrice Gibbs, W. Charles O'Neill, Arlene B. Chapman

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is marked by gradual renal cyst and kidney enlargement and ultimately renal failure. Magnetic resonance-based, height-adjusted total kidney volume (htTKV) over 600 cc/m predicts the development of CKD stage 3 within 8 years in the Consortium for Radiologic Imaging in Polycystic Kidney Disease cohort. Here we compared simultaneous ultrasound and magnetic resonance imaging to determine whether ultrasound and kidney length (KL) predict future CKD stage 3 over longer periods of follow-up. A total of 241 ADPKD patients, 15-46 years, with creatinine clearance of 70 ml/min and above had iothalamate clearance, magnetic resonance, and ultrasound evaluations. Participants underwent an average of five repeat clearance measurements over a mean follow-up of 9.3 years. Ultrasound and magnetic resonance-based TKV and KL were compared using Bland-Altman plots and intraclass correlations. Each measure was tested to predict future CKD stage 3. Relatively strong intraclass correlations between ultrasound and magnetic resonance were found for both htTKV and KL (0.81 and 0.85, respectively). Ultrasound and magnetic resonance-based htTKV and KL predicted future CKD stage 3 similarly (AUC of 0.87, 0.88, 0.87, and 0.88, respectively). An ultrasound kidney length over 16.5 cm and htTKV over 650 ml/min had the best cut point for predicting the development of CKD stage 3. Thus, kidney length alone is sufficient to stratify the risk of progression to renal insufficiency early in ADPKD using either ultrasound or magnetic resonance imaging.

Original languageEnglish (US)
Pages (from-to)146-151
Number of pages6
JournalKidney International
Volume88
Issue number1
DOIs
StatePublished - Jul 2 2015

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Autosomal Dominant Polycystic Kidney
Chronic Renal Insufficiency
Magnetic Resonance Imaging
Kidney
Magnetic Resonance Spectroscopy
Renal Insufficiency
Iothalamic Acid
Polycystic Kidney Diseases
Area Under Curve
Cysts
Creatinine

Keywords

  • Magnetic resonance imaging
  • Total kidney volume
  • Ultrasound

ASJC Scopus subject areas

  • Nephrology

Cite this

A comparison of ultrasound and magnetic resonance imaging shows that kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease. / Bhutani, Harpreet; Smith, Vikram; Rahbari-Oskoui, Frederic; Mittal, Ankush; Grantham, Jared J.; Torres, Vicente; Mrug, Michal; Bae, Kyongtae T.; Wu, Zhiyuan; Ge, Yinghui; Landslittel, Doug; Gibbs, Patrice; O'Neill, W. Charles; Chapman, Arlene B.

In: Kidney International, Vol. 88, No. 1, 02.07.2015, p. 146-151.

Research output: Contribution to journalArticle

Bhutani, H, Smith, V, Rahbari-Oskoui, F, Mittal, A, Grantham, JJ, Torres, V, Mrug, M, Bae, KT, Wu, Z, Ge, Y, Landslittel, D, Gibbs, P, O'Neill, WC & Chapman, AB 2015, 'A comparison of ultrasound and magnetic resonance imaging shows that kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease', Kidney International, vol. 88, no. 1, pp. 146-151. https://doi.org/10.1038/ki.2015.71
Bhutani, Harpreet ; Smith, Vikram ; Rahbari-Oskoui, Frederic ; Mittal, Ankush ; Grantham, Jared J. ; Torres, Vicente ; Mrug, Michal ; Bae, Kyongtae T. ; Wu, Zhiyuan ; Ge, Yinghui ; Landslittel, Doug ; Gibbs, Patrice ; O'Neill, W. Charles ; Chapman, Arlene B. / A comparison of ultrasound and magnetic resonance imaging shows that kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease. In: Kidney International. 2015 ; Vol. 88, No. 1. pp. 146-151.
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AU - Mrug, Michal

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AU - Ge, Yinghui

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N2 - Autosomal dominant polycystic kidney disease (ADPKD) is marked by gradual renal cyst and kidney enlargement and ultimately renal failure. Magnetic resonance-based, height-adjusted total kidney volume (htTKV) over 600 cc/m predicts the development of CKD stage 3 within 8 years in the Consortium for Radiologic Imaging in Polycystic Kidney Disease cohort. Here we compared simultaneous ultrasound and magnetic resonance imaging to determine whether ultrasound and kidney length (KL) predict future CKD stage 3 over longer periods of follow-up. A total of 241 ADPKD patients, 15-46 years, with creatinine clearance of 70 ml/min and above had iothalamate clearance, magnetic resonance, and ultrasound evaluations. Participants underwent an average of five repeat clearance measurements over a mean follow-up of 9.3 years. Ultrasound and magnetic resonance-based TKV and KL were compared using Bland-Altman plots and intraclass correlations. Each measure was tested to predict future CKD stage 3. Relatively strong intraclass correlations between ultrasound and magnetic resonance were found for both htTKV and KL (0.81 and 0.85, respectively). Ultrasound and magnetic resonance-based htTKV and KL predicted future CKD stage 3 similarly (AUC of 0.87, 0.88, 0.87, and 0.88, respectively). An ultrasound kidney length over 16.5 cm and htTKV over 650 ml/min had the best cut point for predicting the development of CKD stage 3. Thus, kidney length alone is sufficient to stratify the risk of progression to renal insufficiency early in ADPKD using either ultrasound or magnetic resonance imaging.

AB - Autosomal dominant polycystic kidney disease (ADPKD) is marked by gradual renal cyst and kidney enlargement and ultimately renal failure. Magnetic resonance-based, height-adjusted total kidney volume (htTKV) over 600 cc/m predicts the development of CKD stage 3 within 8 years in the Consortium for Radiologic Imaging in Polycystic Kidney Disease cohort. Here we compared simultaneous ultrasound and magnetic resonance imaging to determine whether ultrasound and kidney length (KL) predict future CKD stage 3 over longer periods of follow-up. A total of 241 ADPKD patients, 15-46 years, with creatinine clearance of 70 ml/min and above had iothalamate clearance, magnetic resonance, and ultrasound evaluations. Participants underwent an average of five repeat clearance measurements over a mean follow-up of 9.3 years. Ultrasound and magnetic resonance-based TKV and KL were compared using Bland-Altman plots and intraclass correlations. Each measure was tested to predict future CKD stage 3. Relatively strong intraclass correlations between ultrasound and magnetic resonance were found for both htTKV and KL (0.81 and 0.85, respectively). Ultrasound and magnetic resonance-based htTKV and KL predicted future CKD stage 3 similarly (AUC of 0.87, 0.88, 0.87, and 0.88, respectively). An ultrasound kidney length over 16.5 cm and htTKV over 650 ml/min had the best cut point for predicting the development of CKD stage 3. Thus, kidney length alone is sufficient to stratify the risk of progression to renal insufficiency early in ADPKD using either ultrasound or magnetic resonance imaging.

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