A comparison of software packages that assess linkage using a variance components approach

E. J. Atkinson; D. Hall; M. De Andrade

doi:10.1002/gepi.2001.21.s1.s81

A comparison of software packages that assess linkage using a variance components approach

E. J. Atkinson, D. Hall, M. De Andrade

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We report single-point and multipoint results from three statistical genetics software packages using a variance components approach for quantitative traits. When possible, we have shown the effects of covariates. Results from GENEHUNTER, SOLAR, and ACT software packages are compared for the quantitative trait immunoglobulin E (IgE) using chromosome 5 asthma familial data from Oxfordshire (England), Perth (Australia), and Freiburg (Germany), and using the genome-wide German data. Although few differences among variance components results for GENEHUNTER, SOLAR, and ACT were detected on a limited region of chromosome 5, these packages showed larger disagreement in the German data for chromosomes 1, 9, and 14.

Original language	English (US)
Pages (from-to)	S81-S88
Journal	Genetic epidemiology
Volume	21
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1002/gepi.2001.21.s1.s81
State	Published - 2001

Keywords

Covariates
Multipoint linkage
Quantitative trait
Variance components

ASJC Scopus subject areas

Epidemiology
Genetics(clinical)

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10.1002/gepi.2001.21.s1.s81

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AB - We report single-point and multipoint results from three statistical genetics software packages using a variance components approach for quantitative traits. When possible, we have shown the effects of covariates. Results from GENEHUNTER, SOLAR, and ACT software packages are compared for the quantitative trait immunoglobulin E (IgE) using chromosome 5 asthma familial data from Oxfordshire (England), Perth (Australia), and Freiburg (Germany), and using the genome-wide German data. Although few differences among variance components results for GENEHUNTER, SOLAR, and ACT were detected on a limited region of chromosome 5, these packages showed larger disagreement in the German data for chromosomes 1, 9, and 14.

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A comparison of software packages that assess linkage using a variance components approach

Abstract

Keywords

ASJC Scopus subject areas

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