A comparison of software packages that assess linkage using a variance components approach

E. J. Atkinson, D. Hall, M. De Andrade

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We report single-point and multipoint results from three statistical genetics software packages using a variance components approach for quantitative traits. When possible, we have shown the effects of covariates. Results from GENEHUNTER, SOLAR, and ACT software packages are compared for the quantitative trait immunoglobulin E (IgE) using chromosome 5 asthma familial data from Oxfordshire (England), Perth (Australia), and Freiburg (Germany), and using the genome-wide German data. Although few differences among variance components results for GENEHUNTER, SOLAR, and ACT were detected on a limited region of chromosome 5, these packages showed larger disagreement in the German data for chromosomes 1, 9, and 14.

Original languageEnglish (US)
Pages (from-to)S81-S88
JournalGenetic epidemiology
Volume21
Issue numberSUPPL. 1
StatePublished - Oct 23 2001

Keywords

  • Covariates
  • Multipoint linkage
  • Quantitative trait
  • Variance components

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'A comparison of software packages that assess linkage using a variance components approach'. Together they form a unique fingerprint.

  • Cite this