A comparison of prostate iodine-125 seed dose planning using computed tomography and ultrasound imaging

C. F. Serago, S. J. Buskirk, N. Karstaedt, M. Wehle, T. C. Igel, H. E. Casale

Research output: Contribution to journalArticle

Abstract

Practitioners have used computed tomography (CT) or transrectal ultrasound (TRUS) imaging for planning the spatial distribution of radioactive seeds for patients with prostate cancer who are treated with transperineal implantation of iodine-125 seeds. It is known that the prostate volumes determined from CT and TRUS differ. These differences may affect the number of seeds implanted and total activity of the implant. We have planned 20 consecutive patients using both CT and TRUS imaging. The results of our study show that pre-implant prostate volumes are about 28% greater when determined from CT imaging compared with TRUS imaging. We also found that, for the patients selected in this study, 24% more seeds (and 25% more total activity) were required to encompass the CT target volume with the same dose contour as the TRUS target volume. Thus, the choice of imaging modality affects prostate brachytherapy planning and should be carefully considered when clinical protocols are designed.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalJournal of Brachytherapy International
Volume16
Issue number2
StatePublished - Jan 1 2000

Keywords

  • Brachytherapy
  • Computed Tomography
  • Prostate
  • Ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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