A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophy

Anette Schrag, Shamira Sheikh, Niall P. Quinn, Andrew J. Lees, Caroline Selai, Chris Mathias, Irene Litvan, Anthony E. Lang, James H. Bower, David J. Burn, Philip Low, Marjan Jahanshahi

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

The objective of this study was to compare subjective health status and its correlates in progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). One hundred eighty-eight patients with PSP and 286 patients with MSA completed EQ-5D and Hospital Depression and Anxiety Scale. The impact on mobility, usual activities, and self-care was similarly high in both groups after similar duration. Fifty-six percent of PSP and 43% of MSA had probable depression, and 37% of both groups had probable anxiety. Patients with PSP had significantly higher depression scores, but groups did not differ in anxiety scores. Patients with MSA had significantly greater pain/discomfort than patients with PSP. The most important association with subjective health status was with depressive symptoms, which accounted for 38% and 29% of EQ-5D variance in patients with PSP and MSA, followed by disease severity and anxiety scores. We conclude that depressive symptoms were common in both disorders, but more severe in PSP. Anxiety symptoms affected 37% of patients in both groups and contributed to impaired subjective health status. Pain was more problematic in MSA than PSP.

Original languageEnglish (US)
Pages (from-to)1077-1081
Number of pages5
JournalMovement Disorders
Volume25
Issue number8
DOIs
StatePublished - Jun 15 2010

Keywords

  • Anxiety
  • Depression
  • Health status
  • Multiple system atrophy
  • Parkinsonism
  • Progressive supranuclear palsy
  • Quality of life

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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