TY - JOUR
T1 - A comparative study of the clinical manifestations of systemic lupus erythematosus in caucasians in Rochester, Minnesota, and Chinese in Singapore, from 1980 to 1992
AU - Thumboo, Julian
AU - Uramoto, Kristine
AU - Michael O'Fallon, W.
AU - Fong, Kok Yong
AU - Boey, Mee Leng
AU - Feng, Pao Hsii
AU - Thio, Szu Tien
AU - Gabriel, Sherine E.
AU - Chng, Hiok Hee
AU - Howe, Hwee Siew
AU - Koh, Ee Tzun
AU - Koh, Wei Howe
AU - Leong, Keng Hong
AU - Leong, Khai Pang
PY - 2001
Y1 - 2001
N2 - Objective. To examine the relationship between ethnicity and major organ involvement at and after diagnosis in community-based cohorts of Caucasian and Chinese systemic lupus erythematosus (SLE) patients resident in Rochester, Minnesota, and Singapore, respectively. Methods. Clinical manifestations at and after diagnosis were compared in Caucasian and Chinese SLE patients. The association between ethnicity and disease manifestations at and after diagnosis was determined using logistic regression and Cox proportional hazards models, respectively, adjusting for the influence of demographic, socioeconomic, diseaserelated, and therapy-related factors. Results. At diagnosis, Caucasian SLE patients were 3 times more likely than Chinese SLE patients to have serositis (odds ratio [OR] 3.11, 95% confidence interval [CI] 1.01-9.71), nearly 7 times more likely to have a hematologic disorder (OR 6.95, 95% CI 2.20-21.97), and far less likely to have a malar rash (OR 0.19, 95% CI 0.07-0.54) or positive antinuclear antibodies (OR 0.11, 95% CI 0.03-0.52). Ethnicity was not associated with the prevalence of proteinuria or central nervous system (CSN) and other major organ involvement at diagnosis. After diagnosis, there was a trend toward less development of proteinuria and other major organ involvement in Caucasians (relative risk [RR] 0.47, 95% CI 0.19-1.15, and RR 0.22, 95% CI 0.05-1.04, respectively). Conclusion. Chinese SLE patients are far less likely to have serositis or a hematologic disorder at diagnosis and may be more likely to develop proteinuria or CNS or other major organ involvement over the course of the disease, compared with Caucasian SLE patients. This may contribute to the increased mortality seen in Chinese SLE patients.
AB - Objective. To examine the relationship between ethnicity and major organ involvement at and after diagnosis in community-based cohorts of Caucasian and Chinese systemic lupus erythematosus (SLE) patients resident in Rochester, Minnesota, and Singapore, respectively. Methods. Clinical manifestations at and after diagnosis were compared in Caucasian and Chinese SLE patients. The association between ethnicity and disease manifestations at and after diagnosis was determined using logistic regression and Cox proportional hazards models, respectively, adjusting for the influence of demographic, socioeconomic, diseaserelated, and therapy-related factors. Results. At diagnosis, Caucasian SLE patients were 3 times more likely than Chinese SLE patients to have serositis (odds ratio [OR] 3.11, 95% confidence interval [CI] 1.01-9.71), nearly 7 times more likely to have a hematologic disorder (OR 6.95, 95% CI 2.20-21.97), and far less likely to have a malar rash (OR 0.19, 95% CI 0.07-0.54) or positive antinuclear antibodies (OR 0.11, 95% CI 0.03-0.52). Ethnicity was not associated with the prevalence of proteinuria or central nervous system (CSN) and other major organ involvement at diagnosis. After diagnosis, there was a trend toward less development of proteinuria and other major organ involvement in Caucasians (relative risk [RR] 0.47, 95% CI 0.19-1.15, and RR 0.22, 95% CI 0.05-1.04, respectively). Conclusion. Chinese SLE patients are far less likely to have serositis or a hematologic disorder at diagnosis and may be more likely to develop proteinuria or CNS or other major organ involvement over the course of the disease, compared with Caucasian SLE patients. This may contribute to the increased mortality seen in Chinese SLE patients.
KW - Caucasoid race
KW - Comparative study
KW - Mongoloid race
KW - Systemic lupus erythematosus
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U2 - 10.1002/1529-0131(200112)45:6<494::aid-art374>3.0.co;2-m
DO - 10.1002/1529-0131(200112)45:6<494::aid-art374>3.0.co;2-m
M3 - Article
C2 - 11762683
AN - SCOPUS:0035207408
SN - 2151-464X
VL - 45
SP - 494
EP - 500
JO - Arthritis Care and Research
JF - Arthritis Care and Research
IS - 6
ER -