A comparative analysis of core needle biopsy and final excision for breast cancer: Histology and marker expression

Matthew Ough, Jose Velasco, Tina J Hieken

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Core needle biopsy (CNB) is used increasingly not only to diagnose breast cancer, but to determine tumor histology, grade and marker expression, select neoadjuvant therapy, and predict sentinel lymph node status. Thus, we undertook this study to evaluate the accuracy of CNB as a predictor of breast cancer histology and marker expression. Methods: We identified 209 Breast Cancer Registry cases with a preoperative CNB and reviewed all clinicopathologic data for accuracy. Statistical analysis was performed with statistical software. Results: CNB unequivocally showed cancer in 93%. Exact tumor histology concordance was 86%. Ductal carcinoma in situ on CNB was upgraded to invasive cancer in 23%. Concordance was substantial for estrogen receptor expression (88%, κ = .71), but kappa values were less than .6 for tumor grade, mitotic rate, progesterone receptor (PR), Ki-67, HER-2/neu, and p53 expression. Conclusions: Reliance on CNB grade and marker expression for critical decision making may be inadvisable. Further study is warranted to optimize breast cancer patient care.

Original languageEnglish (US)
Pages (from-to)685-687
Number of pages3
JournalAmerican Journal of Surgery
Volume201
Issue number5
DOIs
StatePublished - May 2011
Externally publishedYes

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Large-Core Needle Biopsy
Histology
Breast Neoplasms
Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Neoadjuvant Therapy
Progesterone Receptors
Estrogen Receptors
Registries
Decision Making
Patient Care
Software

Keywords

  • Breast cancer
  • Core needle biopsy
  • Her-2/neu
  • Histology
  • p53
  • Tumor markers

ASJC Scopus subject areas

  • Surgery

Cite this

A comparative analysis of core needle biopsy and final excision for breast cancer : Histology and marker expression. / Ough, Matthew; Velasco, Jose; Hieken, Tina J.

In: American Journal of Surgery, Vol. 201, No. 5, 05.2011, p. 685-687.

Research output: Contribution to journalArticle

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