TY - JOUR
T1 - A CNV-Distraction Paradigm in Combat Veterans with Posttraumatic Stress Disorder
AU - Kimble, Matthew
AU - Ruddy, Kathryn
AU - Deldin, Patricia
AU - Kaufman, Milissa
PY - 2004
Y1 - 2004
N2 - Fourteen veterans with posttraumatic stress disorder (PTSD) and 14 without PTSD participated in a contingent negative variation (CNV)-distraction paradigm. Subjects were instructed to press a button after hearing a high-pitched tone (S2) preceded by a low-pitched tone (S1). One-half of the trials included a white-noise distracter placed in the S1-S2 interval. Posttraumatic stress disorder subjects had larger frontal, but smaller central and parietal CNVs, regardless of condition (distracter, no distracter) or epoch (early CNV, late CNV). In PTSD subjects, the N1/P2 complex was smaller to warning (S1) and distracter stimuli and did not show the extent of facilitation present in non-PTSD subjects. Findings highlight PTSD-related differences in phasic cortical excitability and attention.
AB - Fourteen veterans with posttraumatic stress disorder (PTSD) and 14 without PTSD participated in a contingent negative variation (CNV)-distraction paradigm. Subjects were instructed to press a button after hearing a high-pitched tone (S2) preceded by a low-pitched tone (S1). One-half of the trials included a white-noise distracter placed in the S1-S2 interval. Posttraumatic stress disorder subjects had larger frontal, but smaller central and parietal CNVs, regardless of condition (distracter, no distracter) or epoch (early CNV, late CNV). In PTSD subjects, the N1/P2 complex was smaller to warning (S1) and distracter stimuli and did not show the extent of facilitation present in non-PTSD subjects. Findings highlight PTSD-related differences in phasic cortical excitability and attention.
UR - http://www.scopus.com/inward/record.url?scp=1242329934&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1242329934&partnerID=8YFLogxK
U2 - 10.1176/jnp.16.1.102
DO - 10.1176/jnp.16.1.102
M3 - Article
C2 - 14990765
AN - SCOPUS:1242329934
SN - 0895-0172
VL - 16
SP - 102
EP - 108
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
IS - 1
ER -