A clinical update in polycythemia vera and essential thrombocythemia

Ayalew Tefferi, Lawrence A. Solberg, Murray N. Silverstein

Research output: Contribution to journalReview article

98 Scopus citations

Abstract

Polycythemia vera and essential thrombocythemia pose specific management issues that distinguish them from other chronic myeloproliferative disorders. They are associated with a better prognosis, as well as a variable risk of thrombohemorrhagic complications. In addition, essential thrombocythemia occurs comparatively more often in young people and women. Treatment strategies for patients with polycythemia vera and essential thrombocythemia must consider the possibility of long-term survival, morbidity from thrombotic complications, transformation into myelofibrosis with myeloid metaplasia or acute myeloid leukemia, and the effect of specific therapies on the incidence of leukemic transformation and on pregnancy. There is increasing concern about the possible leukemogenic effect of hydroxyurea. Newer therapeutic agents, including interferon alpha and anagrelide, are being used more often. Ongoing studies are reexamining the effects of low- dose aspirin in preventing thrombotic complications. (C) 2000 by Excerpta Medica, Inc.

Original languageEnglish (US)
Pages (from-to)141-149
Number of pages9
JournalAmerican Journal of Medicine
Volume109
Issue number2
DOIs
StatePublished - Aug 1 2000

ASJC Scopus subject areas

  • Medicine(all)

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