A chronic wound model to investigate skin cellular senescence

Saranya P. Wyles; Parisa Dashti; Tamar Pirtskhalava; Burak Tekin; Christina Inman; Lilian Sales Gomez; Anthony B. Lagnado; Larissa Prata; Diana Jurk; João F. Passos; Tamar Tchkonia; James L. Kirkland

doi:10.18632/aging.204667

A chronic wound model to investigate skin cellular senescence

Saranya P. Wyles, Parisa Dashti, Tamar Pirtskhalava, Burak Tekin, Christina Inman, Lilian Sales Gomez, Anthony B. Lagnado, Larissa Prata, Diana Jurk, João F. Passos, Tamar Tchkonia, James L. Kirkland

Research output: Contribution to journal › Article › peer-review

Abstract

Wound healing is an essential physiological process for restoring normal skin structure and function post-injury. The role of cellular senescence, an essentially irreversible cell cycle state in response to damaging stimuli, has emerged as a critical mechanism in wound remodeling. Transiently-induced senescence during tissue remodeling has been shown to be beneficial in the acute wound healing phase. In contrast, persistent senescence, as observed in chronic wounds, contributes to delayed closure.

Original language	English (US)
Pages (from-to)	2852-2862
Number of pages	11
Journal	Aging
Volume	15
Issue number	8
DOIs	https://doi.org/10.18632/aging.204667
State	Published - 2023

Keywords

cellular senescence
chronic wound
re-epithelization
skin
wound healing

ASJC Scopus subject areas

Aging
Cell Biology

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10.18632/aging.204667

Cite this

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abstract = "Wound healing is an essential physiological process for restoring normal skin structure and function post-injury. The role of cellular senescence, an essentially irreversible cell cycle state in response to damaging stimuli, has emerged as a critical mechanism in wound remodeling. Transiently-induced senescence during tissue remodeling has been shown to be beneficial in the acute wound healing phase. In contrast, persistent senescence, as observed in chronic wounds, contributes to delayed closure.",

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AU - Wyles, Saranya P.

AU - Dashti, Parisa

AU - Pirtskhalava, Tamar

AU - Tekin, Burak

AU - Inman, Christina

AU - Gomez, Lilian Sales

AU - Lagnado, Anthony B.

AU - Prata, Larissa

AU - Jurk, Diana

AU - Passos, João F.

AU - Tchkonia, Tamar

AU - Kirkland, James L.

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PY - 2023

Y1 - 2023

N2 - Wound healing is an essential physiological process for restoring normal skin structure and function post-injury. The role of cellular senescence, an essentially irreversible cell cycle state in response to damaging stimuli, has emerged as a critical mechanism in wound remodeling. Transiently-induced senescence during tissue remodeling has been shown to be beneficial in the acute wound healing phase. In contrast, persistent senescence, as observed in chronic wounds, contributes to delayed closure.

AB - Wound healing is an essential physiological process for restoring normal skin structure and function post-injury. The role of cellular senescence, an essentially irreversible cell cycle state in response to damaging stimuli, has emerged as a critical mechanism in wound remodeling. Transiently-induced senescence during tissue remodeling has been shown to be beneficial in the acute wound healing phase. In contrast, persistent senescence, as observed in chronic wounds, contributes to delayed closure.

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A chronic wound model to investigate skin cellular senescence

Abstract

Keywords

ASJC Scopus subject areas

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