TY - JOUR
T1 - A case of hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli after pericardiectomy
AU - Tome, June
AU - Maselli, Daniel Barry
AU - Im, Roeun
AU - Amdahl, Matthew Brian
AU - Pfeifle, Daniel
AU - Hagen, Catherine
AU - Halland, Magnus
N1 - Publisher Copyright:
© 2021, Japanese Society of Gastroenterology.
PY - 2022/2
Y1 - 2022/2
N2 - The majority of cases of Shiga toxin-producing Escherichia coli are self-limited; however, the infection can occasionally be complicated by more severe phenomena, such as thrombotic microangiopathy, with resultant end-organ damage to the kidneys, colon, nervous system, and various other tissues. Shiga toxin-induced hemolytic uremic syndrome (ST-HUS)—the constellation of thrombocytopenia, hemolysis, and renal failure resulting from thrombotic microangiopathy in a subset of infections producing the Shiga toxin—is classically observed in the pediatric population. Nevertheless, the diagnosis should be considered in adults with this presentation, and especially in those with colonic findings suggestive of ischemia. ST-HUS must also be distinguished from other thrombotic microangiopathies and related conditions, such as disseminated intravascular coagulation, thrombotic thrombocytopenic purpura, and complement-mediated HUS, as these diagnoses prompt alternate management strategies. Here, we present a case of ST-HUS in a gentleman following pericardiectomy who was infected with non-O157:H7 E. coli producing Shiga toxin 2.
AB - The majority of cases of Shiga toxin-producing Escherichia coli are self-limited; however, the infection can occasionally be complicated by more severe phenomena, such as thrombotic microangiopathy, with resultant end-organ damage to the kidneys, colon, nervous system, and various other tissues. Shiga toxin-induced hemolytic uremic syndrome (ST-HUS)—the constellation of thrombocytopenia, hemolysis, and renal failure resulting from thrombotic microangiopathy in a subset of infections producing the Shiga toxin—is classically observed in the pediatric population. Nevertheless, the diagnosis should be considered in adults with this presentation, and especially in those with colonic findings suggestive of ischemia. ST-HUS must also be distinguished from other thrombotic microangiopathies and related conditions, such as disseminated intravascular coagulation, thrombotic thrombocytopenic purpura, and complement-mediated HUS, as these diagnoses prompt alternate management strategies. Here, we present a case of ST-HUS in a gentleman following pericardiectomy who was infected with non-O157:H7 E. coli producing Shiga toxin 2.
KW - Microangiopathic hemolytic anemia
KW - Pseudomembranous colitis
KW - Shiga toxin-producing Escherichia coli
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U2 - 10.1007/s12328-021-01539-8
DO - 10.1007/s12328-021-01539-8
M3 - Article
C2 - 34677733
AN - SCOPUS:85117468207
SN - 1865-7257
VL - 15
SP - 123
EP - 127
JO - Clinical Journal of Gastroenterology
JF - Clinical Journal of Gastroenterology
IS - 1
ER -