Abstract
CCND1-IGH@ translocation is considered pathognomonic of mantle cell lymphoma (MCL), as this distinct chromosomal abnormality has not been reported in any other subtypes of mature B-cell lymphoma. Despite this unifying cytogenetic feature, MCL encompasses 2 distinct groups: the usual MCLs with an overall survival of 3 to 5 years and the so-called "indolent non-nodal mantle cell lymphomas (INNMCLs)." The latter group of MCLs has quite distinctive clinical features, including frequent neoplastic lymphocytosis, absent peripheral lymphadenopathy, and indolent clinical courses. The clinical, biological, and molecular characteristics of INNMCL are still not well understood. Herein, we report a patient with clinical and cytogenetic features of INNMCL with overlapping morphologic and immunophenotypic features resembling hairy cell leukemia (HCL). After failing the chemotherapeutic regimen for MCL, he received a HCL-directed therapy and achieved durable response. This case suggests that CCND1-IGH@ may rarely occur in other mature B-cell neoplasms such as HCL. Further clinicopathologic studies of the so-called "INNMCL" are warranted.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1080-1084 |
| Number of pages | 5 |
| Journal | American Journal of Surgical Pathology |
| Volume | 35 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2011 |
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Keywords
- CCND1-IGH@
- hairy cell leukemia
- mantle cell lymphoma
ASJC Scopus subject areas
- Anatomy
- Pathology and Forensic Medicine
- Surgery
Cite this
A case of hairy cell leukemia with CCND1-IGH@ translocation : Indolent non-nodal mantle cell lymphoma revisited. / Chen, Dong; Ketterling, Rhett P.; Hanson, Curtis A.; Colgan, Joseph P.; Zent, Clive S.; Viswanatha, David S.
In: American Journal of Surgical Pathology, Vol. 35, No. 7, 07.2011, p. 1080-1084.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A case of hairy cell leukemia with CCND1-IGH@ translocation
T2 - Indolent non-nodal mantle cell lymphoma revisited
AU - Chen, Dong
AU - Ketterling, Rhett P.
AU - Hanson, Curtis A.
AU - Colgan, Joseph P.
AU - Zent, Clive S.
AU - Viswanatha, David S.
PY - 2011/7
Y1 - 2011/7
N2 - CCND1-IGH@ translocation is considered pathognomonic of mantle cell lymphoma (MCL), as this distinct chromosomal abnormality has not been reported in any other subtypes of mature B-cell lymphoma. Despite this unifying cytogenetic feature, MCL encompasses 2 distinct groups: the usual MCLs with an overall survival of 3 to 5 years and the so-called "indolent non-nodal mantle cell lymphomas (INNMCLs)." The latter group of MCLs has quite distinctive clinical features, including frequent neoplastic lymphocytosis, absent peripheral lymphadenopathy, and indolent clinical courses. The clinical, biological, and molecular characteristics of INNMCL are still not well understood. Herein, we report a patient with clinical and cytogenetic features of INNMCL with overlapping morphologic and immunophenotypic features resembling hairy cell leukemia (HCL). After failing the chemotherapeutic regimen for MCL, he received a HCL-directed therapy and achieved durable response. This case suggests that CCND1-IGH@ may rarely occur in other mature B-cell neoplasms such as HCL. Further clinicopathologic studies of the so-called "INNMCL" are warranted.
AB - CCND1-IGH@ translocation is considered pathognomonic of mantle cell lymphoma (MCL), as this distinct chromosomal abnormality has not been reported in any other subtypes of mature B-cell lymphoma. Despite this unifying cytogenetic feature, MCL encompasses 2 distinct groups: the usual MCLs with an overall survival of 3 to 5 years and the so-called "indolent non-nodal mantle cell lymphomas (INNMCLs)." The latter group of MCLs has quite distinctive clinical features, including frequent neoplastic lymphocytosis, absent peripheral lymphadenopathy, and indolent clinical courses. The clinical, biological, and molecular characteristics of INNMCL are still not well understood. Herein, we report a patient with clinical and cytogenetic features of INNMCL with overlapping morphologic and immunophenotypic features resembling hairy cell leukemia (HCL). After failing the chemotherapeutic regimen for MCL, he received a HCL-directed therapy and achieved durable response. This case suggests that CCND1-IGH@ may rarely occur in other mature B-cell neoplasms such as HCL. Further clinicopathologic studies of the so-called "INNMCL" are warranted.
KW - CCND1-IGH@
KW - hairy cell leukemia
KW - mantle cell lymphoma
UR - http://www.scopus.com/inward/record.url?scp=79959633500&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959633500&partnerID=8YFLogxK
U2 - 10.1097/PAS.0b013e31821ddaec
DO - 10.1097/PAS.0b013e31821ddaec
M3 - Article
VL - 35
SP - 1080
EP - 1084
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
SN - 0147-5185
IS - 7
ER -