Abstract
Extraneural glioblastoma metastases are exceedingly rare, though previously described in the literature. Activating mutations in the BRAF kinase gene (V600E) are present in a minority of glioblastoma patients. Here, we describe a case of systemic metastases of a clonal subpopulation of BRAF V600E mutated glioblastoma in a patient previously treated with surgery, radiation, temozolomide and bevacizumab. The patient presented with a subacute cervical myelopathy during adjuvant treatment. He underwent emergent surgical decompression of an epidural spine metastasis. Analysis of the metastatic tumor demonstrated clonal expansion of a BRAF V600E subpopulation. Though rare, systemic metastasis of glioblastoma should be considered in patients presenting with subacute complaints in line with a mass lesion.
Original language | English (US) |
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Pages (from-to) | 181-185 |
Number of pages | 5 |
Journal | Brain Tumor Pathology |
Volume | 35 |
Issue number | 3 |
DOIs | |
State | Published - Jul 1 2018 |
Keywords
- BRAF V600E
- Glioblastoma
- L’hermitte’s phenomenon
- Metastasis
ASJC Scopus subject areas
- Oncology
- Clinical Neurology
- Cancer Research