A case of epidural glioblastoma metastasis presenting with a cervical myelopathy, torticollis, and L’hermitte’s phenomenon

Michael W. Ruff, Adip G. Bhargav, Aditya Raghunathan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Extraneural glioblastoma metastases are exceedingly rare, though previously described in the literature. Activating mutations in the BRAF kinase gene (V600E) are present in a minority of glioblastoma patients. Here, we describe a case of systemic metastases of a clonal subpopulation of BRAF V600E mutated glioblastoma in a patient previously treated with surgery, radiation, temozolomide and bevacizumab. The patient presented with a subacute cervical myelopathy during adjuvant treatment. He underwent emergent surgical decompression of an epidural spine metastasis. Analysis of the metastatic tumor demonstrated clonal expansion of a BRAF V600E subpopulation. Though rare, systemic metastasis of glioblastoma should be considered in patients presenting with subacute complaints in line with a mass lesion.

Original languageEnglish (US)
Pages (from-to)181-185
Number of pages5
JournalBrain Tumor Pathology
Volume35
Issue number3
DOIs
StatePublished - Jul 1 2018

Fingerprint

Torticollis
Spinal Cord Diseases
Glioblastoma
Neoplasm Metastasis
temozolomide
Proto-Oncogene Proteins B-raf
Surgical Decompression
Spine
Radiation
Mutation
Genes
Neoplasms
Therapeutics

Keywords

  • BRAF V600E
  • Glioblastoma
  • L’hermitte’s phenomenon
  • Metastasis

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

A case of epidural glioblastoma metastasis presenting with a cervical myelopathy, torticollis, and L’hermitte’s phenomenon. / Ruff, Michael W.; Bhargav, Adip G.; Raghunathan, Aditya.

In: Brain Tumor Pathology, Vol. 35, No. 3, 01.07.2018, p. 181-185.

Research output: Contribution to journalArticle

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