TY - JOUR
T1 - A case of down’s syndrome with diffuse lewy body disease and alzheimerဩs disease
AU - Bodhireddy, Surender
AU - Dickson, Dennis W.
AU - Mattiace, Linda
AU - Weidenheim, Karen M.
PY - 1994/1
Y1 - 1994/1
N2 - Almost all Down’s syndrome (DS) patients over the age of 35 to 40 years have histologic features of Alzheimer’s disease (AD). However, the presence of extrapyramidal features in up to 364 of these patients has no satisfactory pathologic explanation. We report an older patient with DS, dementia, and parkinsonian signs who showed pathologic changes of Parkinson's disease and cortical Lewy bodies in addition to AD. These parkinsonian changes may be related to chromosome 21 abnormalities.
AB - Almost all Down’s syndrome (DS) patients over the age of 35 to 40 years have histologic features of Alzheimer’s disease (AD). However, the presence of extrapyramidal features in up to 364 of these patients has no satisfactory pathologic explanation. We report an older patient with DS, dementia, and parkinsonian signs who showed pathologic changes of Parkinson's disease and cortical Lewy bodies in addition to AD. These parkinsonian changes may be related to chromosome 21 abnormalities.
UR - http://www.scopus.com/inward/record.url?scp=0028011107&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028011107&partnerID=8YFLogxK
U2 - 10.1212/wnl.44.1.159
DO - 10.1212/wnl.44.1.159
M3 - Article
C2 - 8290054
AN - SCOPUS:0028011107
SN - 0028-3878
VL - 44
SP - 159
EP - 161
JO - Neurology
JF - Neurology
IS - 1
ER -