A case of Down's syndrome with diffuse Lewy body disease and Alzheimer's disease

Surender Bodhireddy, Dennis W Dickson, Linda Mattiace, Karen M. Weidenheim

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Almost all Down's syndrome (DS) patients over the age of 35 to 40 years have histologic features of Alzheimer's disease (AD). However, the presence of extrapyramidal features in up to 36% of these patients has no satisfactory pathologic explanation. We report an older patient with DS, dementia, and parkinsonian signs who showed pathologic changes of Parkinson's disease and cortical Lewy bodies in addition to AD. These parkinsonian changes may be related to chromosome 21 abnormalities.

Original languageEnglish (US)
Pages (from-to)159-161
Number of pages3
JournalNeurology
Volume44
Issue number1
StatePublished - Jan 1994
Externally publishedYes

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Lewy Body Disease
Down Syndrome
Alzheimer Disease
Chromosomes, Human, Pair 21
Chromosome Aberrations
Parkinson Disease
Dementia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bodhireddy, S., Dickson, D. W., Mattiace, L., & Weidenheim, K. M. (1994). A case of Down's syndrome with diffuse Lewy body disease and Alzheimer's disease. Neurology, 44(1), 159-161.

A case of Down's syndrome with diffuse Lewy body disease and Alzheimer's disease. / Bodhireddy, Surender; Dickson, Dennis W; Mattiace, Linda; Weidenheim, Karen M.

In: Neurology, Vol. 44, No. 1, 01.1994, p. 159-161.

Research output: Contribution to journalArticle

Bodhireddy, S, Dickson, DW, Mattiace, L & Weidenheim, KM 1994, 'A case of Down's syndrome with diffuse Lewy body disease and Alzheimer's disease', Neurology, vol. 44, no. 1, pp. 159-161.
Bodhireddy S, Dickson DW, Mattiace L, Weidenheim KM. A case of Down's syndrome with diffuse Lewy body disease and Alzheimer's disease. Neurology. 1994 Jan;44(1):159-161.
Bodhireddy, Surender ; Dickson, Dennis W ; Mattiace, Linda ; Weidenheim, Karen M. / A case of Down's syndrome with diffuse Lewy body disease and Alzheimer's disease. In: Neurology. 1994 ; Vol. 44, No. 1. pp. 159-161.
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