A case-control study of tobacco use and other non-occupational risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma (United States)

J. C. Schroeder, A. F. Olshan, R. Baric, G. A. Dent, C. R. Weinberg, B. Yount, James R Cerhan, C. F. Lynch, L. M. Schuman, P. E. Tolbert, N. Rothman, K. P. Cantor, A. Blair

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Objective: Non-Hodgkin's lymphoma (NHL) encompasses diverse subtypes, and analyzing NHL as a single outcome may mask associations. In a new approach we evaluated associations with subtypes defined by the t(14;18) translocation, reasoning that cases within these subtypes would have more common risk factors than all NHL combined. Methods: Archival biopsies from cases in a population-based NHL study were assayed for t(14;18) using polymerase chain reaction amplification. Exposures in 68 t(14;18)-positive and 114-negative cases were compared with 1245 controls. The expectation-maximization algorithm was used to fit polytomous regression models based on all available information, including data from 440 unclassified cases. Results: Family history of hemolymphatic cancer was associated with t(14;18)-negative NHL (odds ratio (OR) 2.4, 95% confidence interval (CI) 1.4-3.9), but not t(14;18)-positive NHL. Cigarette smoking was weakly associated with t(14;18)-positive NHL (OR 1.7, CI 0.9-3.3), but ORs decreased as smoking increased. Chewing tobacco was associated with t(14;18)-positive NHL, particularly when used before age 18 (OR 2.5, CI 1.0-6.0, 13 exposed cases). Odds ratios for both case-subtypes were doubled among hair-dye users. Conclusions: Cigarette smoking was not clearly associated with t(14;18)-positive NHL. Family history may be a marker for factors that act specifically through t(14;18)-negative pathogenic mechanisms.

Original languageEnglish (US)
Pages (from-to)159-168
Number of pages10
JournalCancer Causes and Control
Volume13
Issue number2
DOIs
StatePublished - 2002

Fingerprint

Tobacco Use
Non-Hodgkin's Lymphoma
Case-Control Studies
Odds Ratio
Smoking
Confidence Intervals
Hair Dyes
Smokeless Tobacco
Masks
Biopsy
Polymerase Chain Reaction

Keywords

  • Bcl-2
  • Epidemiology
  • Lymphoma
  • Molecular genes
  • Non-Hodgkin
  • Tobacco
  • Translocation (genetics)

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

A case-control study of tobacco use and other non-occupational risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma (United States). / Schroeder, J. C.; Olshan, A. F.; Baric, R.; Dent, G. A.; Weinberg, C. R.; Yount, B.; Cerhan, James R; Lynch, C. F.; Schuman, L. M.; Tolbert, P. E.; Rothman, N.; Cantor, K. P.; Blair, A.

In: Cancer Causes and Control, Vol. 13, No. 2, 2002, p. 159-168.

Research output: Contribution to journalArticle

Schroeder, JC, Olshan, AF, Baric, R, Dent, GA, Weinberg, CR, Yount, B, Cerhan, JR, Lynch, CF, Schuman, LM, Tolbert, PE, Rothman, N, Cantor, KP & Blair, A 2002, 'A case-control study of tobacco use and other non-occupational risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma (United States)', Cancer Causes and Control, vol. 13, no. 2, pp. 159-168. https://doi.org/10.1023/A:1014397920185
Schroeder, J. C. ; Olshan, A. F. ; Baric, R. ; Dent, G. A. ; Weinberg, C. R. ; Yount, B. ; Cerhan, James R ; Lynch, C. F. ; Schuman, L. M. ; Tolbert, P. E. ; Rothman, N. ; Cantor, K. P. ; Blair, A. / A case-control study of tobacco use and other non-occupational risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma (United States). In: Cancer Causes and Control. 2002 ; Vol. 13, No. 2. pp. 159-168.
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abstract = "Objective: Non-Hodgkin's lymphoma (NHL) encompasses diverse subtypes, and analyzing NHL as a single outcome may mask associations. In a new approach we evaluated associations with subtypes defined by the t(14;18) translocation, reasoning that cases within these subtypes would have more common risk factors than all NHL combined. Methods: Archival biopsies from cases in a population-based NHL study were assayed for t(14;18) using polymerase chain reaction amplification. Exposures in 68 t(14;18)-positive and 114-negative cases were compared with 1245 controls. The expectation-maximization algorithm was used to fit polytomous regression models based on all available information, including data from 440 unclassified cases. Results: Family history of hemolymphatic cancer was associated with t(14;18)-negative NHL (odds ratio (OR) 2.4, 95{\%} confidence interval (CI) 1.4-3.9), but not t(14;18)-positive NHL. Cigarette smoking was weakly associated with t(14;18)-positive NHL (OR 1.7, CI 0.9-3.3), but ORs decreased as smoking increased. Chewing tobacco was associated with t(14;18)-positive NHL, particularly when used before age 18 (OR 2.5, CI 1.0-6.0, 13 exposed cases). Odds ratios for both case-subtypes were doubled among hair-dye users. Conclusions: Cigarette smoking was not clearly associated with t(14;18)-positive NHL. Family history may be a marker for factors that act specifically through t(14;18)-negative pathogenic mechanisms.",
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AU - Schroeder, J. C.

AU - Olshan, A. F.

AU - Baric, R.

AU - Dent, G. A.

AU - Weinberg, C. R.

AU - Yount, B.

AU - Cerhan, James R

AU - Lynch, C. F.

AU - Schuman, L. M.

AU - Tolbert, P. E.

AU - Rothman, N.

AU - Cantor, K. P.

AU - Blair, A.

PY - 2002

Y1 - 2002

N2 - Objective: Non-Hodgkin's lymphoma (NHL) encompasses diverse subtypes, and analyzing NHL as a single outcome may mask associations. In a new approach we evaluated associations with subtypes defined by the t(14;18) translocation, reasoning that cases within these subtypes would have more common risk factors than all NHL combined. Methods: Archival biopsies from cases in a population-based NHL study were assayed for t(14;18) using polymerase chain reaction amplification. Exposures in 68 t(14;18)-positive and 114-negative cases were compared with 1245 controls. The expectation-maximization algorithm was used to fit polytomous regression models based on all available information, including data from 440 unclassified cases. Results: Family history of hemolymphatic cancer was associated with t(14;18)-negative NHL (odds ratio (OR) 2.4, 95% confidence interval (CI) 1.4-3.9), but not t(14;18)-positive NHL. Cigarette smoking was weakly associated with t(14;18)-positive NHL (OR 1.7, CI 0.9-3.3), but ORs decreased as smoking increased. Chewing tobacco was associated with t(14;18)-positive NHL, particularly when used before age 18 (OR 2.5, CI 1.0-6.0, 13 exposed cases). Odds ratios for both case-subtypes were doubled among hair-dye users. Conclusions: Cigarette smoking was not clearly associated with t(14;18)-positive NHL. Family history may be a marker for factors that act specifically through t(14;18)-negative pathogenic mechanisms.

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KW - Lymphoma

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KW - Tobacco

KW - Translocation (genetics)

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