A case-control study of tobacco use and other non-occupational risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma (United States)

J. C. Schroeder, A. F. Olshan, R. Baric, G. A. Dent, C. R. Weinberg, B. Yount, J. R. Cerhan, C. F. Lynch, L. M. Schuman, P. E. Tolbert, N. Rothman, K. P. Cantor, A. Blair

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Abstract

Objective: Non-Hodgkin's lymphoma (NHL) encompasses diverse subtypes, and analyzing NHL as a single outcome may mask associations. In a new approach we evaluated associations with subtypes defined by the t(14;18) translocation, reasoning that cases within these subtypes would have more common risk factors than all NHL combined. Methods: Archival biopsies from cases in a population-based NHL study were assayed for t(14;18) using polymerase chain reaction amplification. Exposures in 68 t(14;18)-positive and 114-negative cases were compared with 1245 controls. The expectation-maximization algorithm was used to fit polytomous regression models based on all available information, including data from 440 unclassified cases. Results: Family history of hemolymphatic cancer was associated with t(14;18)-negative NHL (odds ratio (OR) 2.4, 95% confidence interval (CI) 1.4-3.9), but not t(14;18)-positive NHL. Cigarette smoking was weakly associated with t(14;18)-positive NHL (OR 1.7, CI 0.9-3.3), but ORs decreased as smoking increased. Chewing tobacco was associated with t(14;18)-positive NHL, particularly when used before age 18 (OR 2.5, CI 1.0-6.0, 13 exposed cases). Odds ratios for both case-subtypes were doubled among hair-dye users. Conclusions: Cigarette smoking was not clearly associated with t(14;18)-positive NHL. Family history may be a marker for factors that act specifically through t(14;18)-negative pathogenic mechanisms.

Original languageEnglish (US)
Pages (from-to)159-168
Number of pages10
JournalCancer Causes and Control
Volume13
Issue number2
DOIs
StatePublished - Mar 26 2002

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Keywords

  • Bcl-2
  • Epidemiology
  • Lymphoma
  • Molecular genes
  • Non-Hodgkin
  • Tobacco
  • Translocation (genetics)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Schroeder, J. C., Olshan, A. F., Baric, R., Dent, G. A., Weinberg, C. R., Yount, B., Cerhan, J. R., Lynch, C. F., Schuman, L. M., Tolbert, P. E., Rothman, N., Cantor, K. P., & Blair, A. (2002). A case-control study of tobacco use and other non-occupational risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma (United States). Cancer Causes and Control, 13(2), 159-168. https://doi.org/10.1023/A:1014397920185