A carbon nanofiber based biosensor for simultaneous detection of dopamine and serotonin in the presence of ascorbic acid

Emily Rand, Adaikkappan Periyakaruppan, Zuki Tanaka, David A. Zhang, Michael P. Marsh, Russell J. Andrews, Kendall H. Lee, Bin Chen, M. Meyyappan, Jessica E. Koehne

Research output: Contribution to journalArticle

94 Scopus citations

Abstract

A biosensor based on an array of vertically aligned carbon nanofibers (CNFs) grown by plasma enhanced chemical vapor deposition is found to be effective for the simultaneous detection of dopamine (DA) and serotonin (5-HT) in the presence of excess ascorbic acid (AA). The CNF electrode outperforms the conventional glassy carbon electrode (GCE) for both selectivity and sensitivity. Using differential pulse voltammetry (DPV), three distinct peaks are seen for the CNF electrode at 0.13. V, 0.45. V, and 0.70. V for the ternary mixture of AA, DA, and 5-HT. In contrast, the analytes are indistinguishable in a mixture using a GCE. For the CNF electrode, the detection limits are 50. nM for DA and 250. nM for 5-HT.

Original languageEnglish (US)
Pages (from-to)434-438
Number of pages5
JournalBiosensors and Bioelectronics
Volume42
Issue number1
DOIs
StatePublished - Apr 5 2013

Keywords

  • Biosensor
  • Carbon nanofiber
  • Dopamine
  • Nanoelectrode array
  • Serotonin

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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  • Cite this

    Rand, E., Periyakaruppan, A., Tanaka, Z., Zhang, D. A., Marsh, M. P., Andrews, R. J., Lee, K. H., Chen, B., Meyyappan, M., & Koehne, J. E. (2013). A carbon nanofiber based biosensor for simultaneous detection of dopamine and serotonin in the presence of ascorbic acid. Biosensors and Bioelectronics, 42(1), 434-438. https://doi.org/10.1016/j.bios.2012.10.080