A carbon nanofiber based biosensor for simultaneous detection of dopamine and serotonin in the presence of ascorbic acid

Emily Rand; Adaikkappan Periyakaruppan; Zuki Tanaka; David A. Zhang; Michael P. Marsh; Russell J. Andrews; Kendall H. Lee; Bin Chen; M. Meyyappan; Jessica E. Koehne

doi:10.1016/j.bios.2012.10.080

A carbon nanofiber based biosensor for simultaneous detection of dopamine and serotonin in the presence of ascorbic acid

Emily Rand, Adaikkappan Periyakaruppan, Zuki Tanaka, David A. Zhang, Michael P. Marsh, Russell J. Andrews, Kendall H. Lee, Bin Chen, M. Meyyappan, Jessica E. Koehne

Neurosurgery

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

A biosensor based on an array of vertically aligned carbon nanofibers (CNFs) grown by plasma enhanced chemical vapor deposition is found to be effective for the simultaneous detection of dopamine (DA) and serotonin (5-HT) in the presence of excess ascorbic acid (AA). The CNF electrode outperforms the conventional glassy carbon electrode (GCE) for both selectivity and sensitivity. Using differential pulse voltammetry (DPV), three distinct peaks are seen for the CNF electrode at 0.13. V, 0.45. V, and 0.70. V for the ternary mixture of AA, DA, and 5-HT. In contrast, the analytes are indistinguishable in a mixture using a GCE. For the CNF electrode, the detection limits are 50. nM for DA and 250. nM for 5-HT.

Original language	English (US)
Pages (from-to)	434-438
Number of pages	5
Journal	Biosensors and Bioelectronics
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/j.bios.2012.10.080
State	Published - Apr 5 2013

Keywords

Biosensor
Carbon nanofiber
Dopamine
Nanoelectrode array
Serotonin

ASJC Scopus subject areas

Biotechnology
Biophysics
Biomedical Engineering
Electrochemistry

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10.1016/j.bios.2012.10.080

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title = "A carbon nanofiber based biosensor for simultaneous detection of dopamine and serotonin in the presence of ascorbic acid",

abstract = "A biosensor based on an array of vertically aligned carbon nanofibers (CNFs) grown by plasma enhanced chemical vapor deposition is found to be effective for the simultaneous detection of dopamine (DA) and serotonin (5-HT) in the presence of excess ascorbic acid (AA). The CNF electrode outperforms the conventional glassy carbon electrode (GCE) for both selectivity and sensitivity. Using differential pulse voltammetry (DPV), three distinct peaks are seen for the CNF electrode at 0.13. V, 0.45. V, and 0.70. V for the ternary mixture of AA, DA, and 5-HT. In contrast, the analytes are indistinguishable in a mixture using a GCE. For the CNF electrode, the detection limits are 50. nM for DA and 250. nM for 5-HT.",

keywords = "Biosensor, Carbon nanofiber, Dopamine, Nanoelectrode array, Serotonin",

author = "Emily Rand and Adaikkappan Periyakaruppan and Zuki Tanaka and Zhang, {David A.} and Marsh, {Michael P.} and Andrews, {Russell J.} and Lee, {Kendall H.} and Bin Chen and M. Meyyappan and Koehne, {Jessica E.}",

note = "Funding Information: This work was in part supported by an NIH Grant ( R01-NS75013 ) to Mayo Clinic. AP was supported by a NASA URC Contract to Texas Southern University ( NNx08BA47A ) as a visiting Postdoctoral Fellow. The authors would like to thank Patrick Wilhite and Anshul Vyas of Santa Clara University for helpful discussions regarding carbon nanofiber growth. ",

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AU - Rand, Emily

AU - Periyakaruppan, Adaikkappan

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AU - Zhang, David A.

AU - Marsh, Michael P.

AU - Andrews, Russell J.

AU - Lee, Kendall H.

AU - Chen, Bin

AU - Meyyappan, M.

AU - Koehne, Jessica E.

N1 - Funding Information: This work was in part supported by an NIH Grant ( R01-NS75013 ) to Mayo Clinic. AP was supported by a NASA URC Contract to Texas Southern University ( NNx08BA47A ) as a visiting Postdoctoral Fellow. The authors would like to thank Patrick Wilhite and Anshul Vyas of Santa Clara University for helpful discussions regarding carbon nanofiber growth.

PY - 2013/4/5

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N2 - A biosensor based on an array of vertically aligned carbon nanofibers (CNFs) grown by plasma enhanced chemical vapor deposition is found to be effective for the simultaneous detection of dopamine (DA) and serotonin (5-HT) in the presence of excess ascorbic acid (AA). The CNF electrode outperforms the conventional glassy carbon electrode (GCE) for both selectivity and sensitivity. Using differential pulse voltammetry (DPV), three distinct peaks are seen for the CNF electrode at 0.13. V, 0.45. V, and 0.70. V for the ternary mixture of AA, DA, and 5-HT. In contrast, the analytes are indistinguishable in a mixture using a GCE. For the CNF electrode, the detection limits are 50. nM for DA and 250. nM for 5-HT.

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A carbon nanofiber based biosensor for simultaneous detection of dopamine and serotonin in the presence of ascorbic acid

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Keywords

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