TY - JOUR
T1 - A 79-Year-Old Man With Recurrent Respiratory and Constitutional Symptoms, Elevated Acute Phase Reactants, and Pancytopenia
AU - Casal Moura, Marta
AU - Yi, Eunhee S.
AU - Koster, Matthew J.
AU - Ryu, Jay H.
AU - Baqir, Misbah
N1 - Funding Information:
Author contributions: M.C.M. J.H.R. and M.B. retrieved the clinical information and conceptualized the case presentation and drafted the original report; E.S.Y. revised the lung biopsy slides and described the findings; M.C.M. E.S.Y. M.J.K. J.H.R. and M.B. revised the original draft; and all the authors approved the final version. Other contributions: Kathleen Louden, ELS, senior scientific/medical editor, Mayo Clinic, substantively edited the manuscript. The Scientific Publications staff, Mayo Clinic, provided proofreading, administrative, and clerical support. CHEST worked with the authors to ensure that the Journal policies on patient consent to report information were met.
Publisher Copyright:
© 2022 American College of Chest Physicians
PY - 2023/5
Y1 - 2023/5
N2 - Case Presentation: A 79-year-old man was examined because of recurrent dyspnea and constitutional symptoms that included malaise, fatigue, fevers, and arthralgias over the past 7 years. He was a nonsmoker who was a retired farmer. Elevated levels of acute phase reactants and C-reactive protein and a high erythrocyte sedimentation rate were noted often in his health records. However, an extensive rheumatologic evaluation, which included serologic studies (antinuclear antibodies, cyclic citrullinated peptide antibodies, antineutrophil cytoplasmic antibodies) and temporal artery biopsy, had not shown an identifiable autoimmune disease. The patient had been treated intermittently with prednisone, with partial symptomatic improvement. Various cytopenias had been present over the preceding years; however, three bone marrow biopsy specimens showed moderately hypercellular bone marrow with no diagnostic findings.
AB - Case Presentation: A 79-year-old man was examined because of recurrent dyspnea and constitutional symptoms that included malaise, fatigue, fevers, and arthralgias over the past 7 years. He was a nonsmoker who was a retired farmer. Elevated levels of acute phase reactants and C-reactive protein and a high erythrocyte sedimentation rate were noted often in his health records. However, an extensive rheumatologic evaluation, which included serologic studies (antinuclear antibodies, cyclic citrullinated peptide antibodies, antineutrophil cytoplasmic antibodies) and temporal artery biopsy, had not shown an identifiable autoimmune disease. The patient had been treated intermittently with prednisone, with partial symptomatic improvement. Various cytopenias had been present over the preceding years; however, three bone marrow biopsy specimens showed moderately hypercellular bone marrow with no diagnostic findings.
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U2 - 10.1016/j.chest.2022.12.016
DO - 10.1016/j.chest.2022.12.016
M3 - Article
AN - SCOPUS:85153619761
SN - 0012-3692
VL - 163
SP - e207-e210
JO - Diseases of the chest
JF - Diseases of the chest
IS - 5
ER -