A 13 kDa fragment is responsible for the hydrophobic aggregation of brain G4 acetylcholinesterase

M. E. Fuentes, T. L. Rosenberry, N. C. Inestrosa

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Proteinase K treatment of the bovine brain acetylcholinesterase (AChE) releases a hydrophobic fragment of 13 kDa, which is entirely responsible for the aggregation of the G4 AChE in the absence of detergent. This observation provides evidence that the 13 kDa fragment, which comes from a previously identified 20 kDa subunit, is directly involved in the attachment of the G4 AChE to brain membranes. A model for the organization of the different sub-domains of the hydrophobic anchor of the G4 AChE is presented.

Original languageEnglish (US)
Pages (from-to)1047-1050
Number of pages4
JournalBiochemical Journal
Volume256
Issue number3
StatePublished - 1988
Externally publishedYes

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Acetylcholinesterase
Brain
Agglomeration
Endopeptidase K
Anchors
Detergents
Membranes

ASJC Scopus subject areas

  • Biochemistry

Cite this

Fuentes, M. E., Rosenberry, T. L., & Inestrosa, N. C. (1988). A 13 kDa fragment is responsible for the hydrophobic aggregation of brain G4 acetylcholinesterase. Biochemical Journal, 256(3), 1047-1050.

A 13 kDa fragment is responsible for the hydrophobic aggregation of brain G4 acetylcholinesterase. / Fuentes, M. E.; Rosenberry, T. L.; Inestrosa, N. C.

In: Biochemical Journal, Vol. 256, No. 3, 1988, p. 1047-1050.

Research output: Contribution to journalArticle

Fuentes, ME, Rosenberry, TL & Inestrosa, NC 1988, 'A 13 kDa fragment is responsible for the hydrophobic aggregation of brain G4 acetylcholinesterase', Biochemical Journal, vol. 256, no. 3, pp. 1047-1050.
Fuentes, M. E. ; Rosenberry, T. L. ; Inestrosa, N. C. / A 13 kDa fragment is responsible for the hydrophobic aggregation of brain G4 acetylcholinesterase. In: Biochemical Journal. 1988 ; Vol. 256, No. 3. pp. 1047-1050.
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