Aβ-Associated cerebral angiopathy and senile plaques with neurofibrillary tangles and cerebral hemorrhage in an aged wolverine (Gulo gulo)

Karen E. Roertgen, Joseph E Parisi, H. Brent Clark, Donald L. Barnes, Timothy D. O'Brien, Kenneth H. Johnson

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

In this study of an aged wolverine (Gulo gulo), we document neuropathologic lesions (cerebral amyloid angiopathy (CAA), neuritic plaques (NPs), neurofibrillary tangles (NFTs), and granulovacuolar degeneration strikingly similar to those present in aging and Alzheimer's disease (AD), with the additional finding of concurrent cerebral hemorrhage. Aβ immunoreactive cerebral amyloid angiopathy and senile plaques (neuritic and diffuse) were present throughout the cerebral cortex and hipocampus. Ubiquitin immunoreactivity was noted in peripheral portions of some of the plaques. Argyrophilic intracellular neurofibrillary tangles containing abnormally phosphorylated (Ser 202) tau protein were present within cortical and hippocampal neurons. The wolverine should be added to the list of nonhuman species (dogs, nonhuman primates, polar bears) with amyloid deposits similar to those in aged humans and in humans with AD. The aged wolverine appears to be distinct from other nonhuman species in possessing plaques and NFTs, as well as other histologic cerebral lesions frequently associated with AD.

Original languageEnglish (US)
Pages (from-to)243-247
Number of pages5
JournalNeurobiology of Aging
Volume17
Issue number2
DOIs
StatePublished - Mar 1996

Fingerprint

Mustelidae
Neurofibrillary Tangles
Amyloid Plaques
Cerebral Hemorrhage
Cerebral Amyloid Angiopathy
Alzheimer Disease
Ursidae
tau Proteins
Ubiquitin
Cerebral Cortex
Primates
Dogs
Neurons

Keywords

  • Alzheimer's disease AD
  • Amyloid β protein
  • Apolipoprotein E apo E
  • Cerebral amyloid angiopathy CAA
  • Cerebral hemorrhage
  • Grnulovacuolar degeneration
  • Neurofibrillary tangles NFTs
  • Plaque
  • Tau
  • Ubiquitin
  • Wolverine

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Aβ-Associated cerebral angiopathy and senile plaques with neurofibrillary tangles and cerebral hemorrhage in an aged wolverine (Gulo gulo). / Roertgen, Karen E.; Parisi, Joseph E; Clark, H. Brent; Barnes, Donald L.; O'Brien, Timothy D.; Johnson, Kenneth H.

In: Neurobiology of Aging, Vol. 17, No. 2, 03.1996, p. 243-247.

Research output: Contribution to journalArticle

Roertgen, Karen E. ; Parisi, Joseph E ; Clark, H. Brent ; Barnes, Donald L. ; O'Brien, Timothy D. ; Johnson, Kenneth H. / Aβ-Associated cerebral angiopathy and senile plaques with neurofibrillary tangles and cerebral hemorrhage in an aged wolverine (Gulo gulo). In: Neurobiology of Aging. 1996 ; Vol. 17, No. 2. pp. 243-247.
@article{e471682f9f8b4f9689c6a87f01cc1e33,
title = "Aβ-Associated cerebral angiopathy and senile plaques with neurofibrillary tangles and cerebral hemorrhage in an aged wolverine (Gulo gulo)",
abstract = "In this study of an aged wolverine (Gulo gulo), we document neuropathologic lesions (cerebral amyloid angiopathy (CAA), neuritic plaques (NPs), neurofibrillary tangles (NFTs), and granulovacuolar degeneration strikingly similar to those present in aging and Alzheimer's disease (AD), with the additional finding of concurrent cerebral hemorrhage. Aβ immunoreactive cerebral amyloid angiopathy and senile plaques (neuritic and diffuse) were present throughout the cerebral cortex and hipocampus. Ubiquitin immunoreactivity was noted in peripheral portions of some of the plaques. Argyrophilic intracellular neurofibrillary tangles containing abnormally phosphorylated (Ser 202) tau protein were present within cortical and hippocampal neurons. The wolverine should be added to the list of nonhuman species (dogs, nonhuman primates, polar bears) with amyloid deposits similar to those in aged humans and in humans with AD. The aged wolverine appears to be distinct from other nonhuman species in possessing plaques and NFTs, as well as other histologic cerebral lesions frequently associated with AD.",
keywords = "Alzheimer's disease AD, Amyloid β protein, Apolipoprotein E apo E, Cerebral amyloid angiopathy CAA, Cerebral hemorrhage, Grnulovacuolar degeneration, Neurofibrillary tangles NFTs, Plaque, Tau, Ubiquitin, Wolverine",
author = "Roertgen, {Karen E.} and Parisi, {Joseph E} and Clark, {H. Brent} and Barnes, {Donald L.} and O'Brien, {Timothy D.} and Johnson, {Kenneth H.}",
year = "1996",
month = "3",
doi = "10.1016/0197-4580(95)02069-1",
language = "English (US)",
volume = "17",
pages = "243--247",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Aβ-Associated cerebral angiopathy and senile plaques with neurofibrillary tangles and cerebral hemorrhage in an aged wolverine (Gulo gulo)

AU - Roertgen, Karen E.

AU - Parisi, Joseph E

AU - Clark, H. Brent

AU - Barnes, Donald L.

AU - O'Brien, Timothy D.

AU - Johnson, Kenneth H.

PY - 1996/3

Y1 - 1996/3

N2 - In this study of an aged wolverine (Gulo gulo), we document neuropathologic lesions (cerebral amyloid angiopathy (CAA), neuritic plaques (NPs), neurofibrillary tangles (NFTs), and granulovacuolar degeneration strikingly similar to those present in aging and Alzheimer's disease (AD), with the additional finding of concurrent cerebral hemorrhage. Aβ immunoreactive cerebral amyloid angiopathy and senile plaques (neuritic and diffuse) were present throughout the cerebral cortex and hipocampus. Ubiquitin immunoreactivity was noted in peripheral portions of some of the plaques. Argyrophilic intracellular neurofibrillary tangles containing abnormally phosphorylated (Ser 202) tau protein were present within cortical and hippocampal neurons. The wolverine should be added to the list of nonhuman species (dogs, nonhuman primates, polar bears) with amyloid deposits similar to those in aged humans and in humans with AD. The aged wolverine appears to be distinct from other nonhuman species in possessing plaques and NFTs, as well as other histologic cerebral lesions frequently associated with AD.

AB - In this study of an aged wolverine (Gulo gulo), we document neuropathologic lesions (cerebral amyloid angiopathy (CAA), neuritic plaques (NPs), neurofibrillary tangles (NFTs), and granulovacuolar degeneration strikingly similar to those present in aging and Alzheimer's disease (AD), with the additional finding of concurrent cerebral hemorrhage. Aβ immunoreactive cerebral amyloid angiopathy and senile plaques (neuritic and diffuse) were present throughout the cerebral cortex and hipocampus. Ubiquitin immunoreactivity was noted in peripheral portions of some of the plaques. Argyrophilic intracellular neurofibrillary tangles containing abnormally phosphorylated (Ser 202) tau protein were present within cortical and hippocampal neurons. The wolverine should be added to the list of nonhuman species (dogs, nonhuman primates, polar bears) with amyloid deposits similar to those in aged humans and in humans with AD. The aged wolverine appears to be distinct from other nonhuman species in possessing plaques and NFTs, as well as other histologic cerebral lesions frequently associated with AD.

KW - Alzheimer's disease AD

KW - Amyloid β protein

KW - Apolipoprotein E apo E

KW - Cerebral amyloid angiopathy CAA

KW - Cerebral hemorrhage

KW - Grnulovacuolar degeneration

KW - Neurofibrillary tangles NFTs

KW - Plaque

KW - Tau

KW - Ubiquitin

KW - Wolverine

UR - http://www.scopus.com/inward/record.url?scp=0029938433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029938433&partnerID=8YFLogxK

U2 - 10.1016/0197-4580(95)02069-1

DO - 10.1016/0197-4580(95)02069-1

M3 - Article

VL - 17

SP - 243

EP - 247

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 2

ER -