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  • Clifford R Jr. Jack
2020

Alzheimer Disease, Biomarkers, and Clinical Symptoms-Quo Vadis?-Reply

Jack, C. R., Jan 1 2020, (Accepted/In press) In : JAMA neurology.

Research output: Contribution to journalLetter

1 Scopus citations

Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease

Dominantly Inherited Alzheimer Network (DIAN) & PREVENT-AD Research Group, 2020, (Accepted/In press) In : Biological psychiatry.

Research output: Contribution to journalArticle

1 Scopus citations

Aortic Stiffness and White Matter Microstructural Integrity Assessed by Diffusion Tensor Imaging: The ARIC-NCS

Wei, J., Palta, P., Meyer, M. L., Kucharska-Newton, A., Pence, B. W., Aiello, A. E., Power, M. C., Walker, K. A., Sharrett, A. R., Tanaka, H., Jack, C. R., Mosley, T. H., Reid, R. I., Reyes, D. A. & Heiss, G., Mar 17 2020, In : Journal of the American Heart Association. 9, 6, p. e014868

Research output: Contribution to journalArticle

Open Access

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

The Dominantly Inherited Alzheimer Network, Mar 1 2020, In : Nature Medicine. 26, 3, p. 398-407 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Author Correction: Multimodal hippocampal subfield grading for Alzheimer’s disease classification (Scientific Reports, (2019), 9, 1, (13845), 10.1038/s41598-019-49970-9)

Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2020, In : Scientific reports. 10, 1, 10969.

Research output: Contribution to journalComment/debate

Open Access

Better stress coping associated with lower tau in amyloid-positive cognitively unimpaired older adults

Arenaza-Urquijo, E. M., Przybelski, S. A., MacHulda, M. M., Knopman, D. S., Lowe, V. J., Mielke, M. M., Reddy, A. L., Geda, Y. E., Jack, C. R., Petersen, R. C. & Vemuri, P., Apr 14 2020, In : Neurology. 94, 15, p. E1571-E1579

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Brain amyloid, cortical thickness, and changes in activities of daily living

Vassilaki, M., Aakre, J. A., Kremers, W. K., Lesnick, T. G., Mielke, M. M., Geda, Y. E., Machulda, M. M., Knopman, D. S., Butler, L., Traber, M., Vemuri, P., Lowe, V. J., Jack, C. R., Roberts, R. O. & Petersen, R. C., Apr 1 2020, In : Annals of Clinical and Translational Neurology. 7, 4, p. 474-485 12 p.

Research output: Contribution to journalArticle

Open Access

Brain imaging measurements of fibrillar amyloid-β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele

Ghisays, V., Goradia, D. D., Protas, H., Bauer, R. J., Devadas, V., Tariot, P. N., Lowe, V. J., Knopman, D. S., Petersen, R. C., Jack, C. R., Caselli, R. J., Su, Y., Chen, K. & Reiman, E. M., Apr 1 2020, In : Alzheimer's and Dementia. 16, 4, p. 598-609 12 p.

Research output: Contribution to journalArticle

Brain volume and flortaucipir analysis of progressive supranuclear palsy clinical variants

Whitwell, J. L., Tosakulwong, N., Botha, H., Ali, F., Clark, H. M., Duffy, J. R., Utianski, R. L., Stevens, C. A., Weigand, S. D., Schwarz, C. G., Senjem, M. L., Jack, C. R., Lowe, V. J., Ahlskog, J. E., Dickson, D. W. & Josephs, K. A., 2020, In : NeuroImage: Clinical. 25, 102152.

Research output: Contribution to journalArticle

Open Access

Cardiorespiratory Fitness and Brain Volumes

Petersen, R. C., Joyner, M. J. & Jack, C. R., Jan 2020, In : Mayo Clinic proceedings. 95, 1, p. 6-8 3 p.

Research output: Contribution to journalEditorial

Open Access
1 Scopus citations

Cerebral microbleed incidence, relationship to amyloid burden: The Mayo Clinic Study of Aging

Graff-Radford, J., Lesnick, T., Rabinstein, A. A., Gunter, J., Aakre, J., Przybelski, S. A., Spychalla, A. J., Huston, J., Brown, R. D., Mielke, M. M., Lowe, V. J., Knopman, D. S., Petersen, R. C., Jack, C. R., Vemuri, P., Kremers, W. & Kantarci, K., Jan 14 2020, In : Neurology. 94, 2, p. e190-e199

Research output: Contribution to journalArticle

Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology

The Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2020, In : Scientific reports. 10, 1, 2975.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities

Armstrong, N. J., Mather, K. A., Mather, K. A., Sargurupremraj, M., Knol, M. J., Malik, R., Satizabal, C. L., Satizabal, C. L., Yanek, L. R., Wen, W., Gudnason, V. G., Dueker, N. D., Elliott, L. T., Hofer, E., Hofer, E., Bis, J., Jahanshad, N., Li, S., Logue, M. A., Logue, M. A. & 106 others, Luciano, M., Scholz, M., Smith, A. V., Trompet, S., Trompet, S., Vojinovic, D., Xia, R., Alfaro-Almagro, F., Ames, D., Ames, D., Amin, N., Amouyel, P., Amouyel, P., Beiser, A. S., Beiser, A. S., Brodaty, H., Brodaty, H., Deary, I. J., Fennema-Notestine, C., Fennema-Notestine, C., Gampawar, P. G., Gottesman, R., Griffanti, L., Jack, C. R., Jenkinson, M., Jiang, J., Kral, B. G., Kwok, J. B., Kwok, J. B., Lampe, L., Liewald, D. C. M., Maillard, P., Marchini, J., Bastin, M. E., Bastin, M. E., Mazoyer, B., Pirpamer, L., Rafael Romero, J., Rafael Romero, J., Roshchupkin, G. V., Roshchupkin, G. V., Schofield, P. R., Schofield, P. R., Schroeter, M. L., Schroeter, M. L., Stott, D. J., Thalamuthu, A., Thalamuthu, A., Trollor, J., Trollor, J., Tzourio, C., Tzourio, C., Van Der Grond, J., Vernooij, M. W., Vernooij, M. W., Witte, V. A., Wright, M. J., Wright, M. J., Yang, Q., Morris, Z., Siggurdsson, S., Siggurdsson, S., Psaty, B., Villringer, A., Villringer, A., Schmidt, H., Haberg, A. K., Haberg, A. K., Van Duijn, C. M., Van Duijn, C. M., Jukema, J. W., Jukema, J. W., Dichgans, M., Dichgans, M., Dichgans, M., Sacco, R. L., Sacco, R. L., Sacco, R. L., Sacco, R. L., Wright, C. B., Kremen, W. S., Kremen, W. S., Becker, L. C., Thompson, P. M., Mosley, T. H., Wardlaw, J. M., Wardlaw, J. M., Ikram, M. A., Adams, H. H. H., Adams, H. H. H., Adams, H. H. H., Seshadri, S., Sachdev, P. S., Sachdev, P. S., Smith, S. M., Launer, L., Longstreth, W., Decarli, C., Schmidt, R., Fornage, M., Fornage, M., Debette, S., Debette, S., Nyquist, P. A., Nyquist, P. A. & Nyquist, P. A., 2020, (Accepted/In press) In : Stroke. p. 2111-2121 11 p.

Research output: Contribution to journalArticle

Open Access

Cortical atrophy patterns of incident MCI subtypes in the Mayo Clinic Study of Aging

Machulda, M. M., Lundt, E. S., Albertson, S. M., Spychalla, A. J., Schwarz, C. G., Mielke, M. M., Jack, C. R., Kremers, W. K., Vemuri, P., Knopman, D. S., Jones, D. T., Bondi, M. W. & Petersen, R. C., Jul 1 2020, In : Alzheimer's and Dementia. 16, 7, p. 1013-1022 10 p.

Research output: Contribution to journalArticle

Open Access

CSF biomarkers in Olmsted County: Evidence of 2 subclasses and associations with demographics

Van Harten, A. C., Wiste, H. J., Weigand, S. D., Mielke, M. M., Kremers, W. K., Eichenlaub, U., Batrla-Utermann, R., Dyer, R. B., Algeciras-Schimnich, A., Knopman, D. S., Jack, C. R. & Petersen, R. C., Jul 21 2020, In : Neurology. 95, 3, p. e256-e267

Research output: Contribution to journalArticle

Effect Modifiers of TDP-43-Associated Hippocampal Atrophy Rates in Patients with Alzheimer's Disease Neuropathological Changes

Buciuc, M., Wennberg, A. M., Weigand, S. D., Murray, M. E., Senjem, M. L., Spychalla, A. J., Boeve, B. F., Knopman, D. S., Jack, C. R., Kantarci, K., Parisi, J. E., Dickson, D. W., Petersen, R. C., Whitwell, J. L. & Josephs, K. A., 2020, In : Journal of Alzheimer's Disease. 73, 4, p. 1511-1523 13 p.

Research output: Contribution to journalArticle

Exposure to surgery with general anaesthesia during adult life is not associated with increased brain amyloid deposition in older adults

Sprung, J., Warner, D. O., Knopman, D. S., Petersen, R. C., Mielke, M. M., Jack, C. R., Lowe, V. J., Martin, D. P., Hanson, A. C., Schroeder, D. R., Przybelski, S. A., Schulte, P. J., Weingarten, T. N. & Vemuri, P., May 2020, In : British journal of anaesthesia. 124, 5, p. 594-602 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

The Alzheimer Disease Neuroimaging Initiative, Dec 1 2020, In : Nature communications. 11, 1, 411.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dec 1 2020, In : Nature communications. 11, 1, 347.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Imaging Biomarkers of Alzheimer Disease in Multiple Sclerosis

Zeydan, B., Lowe, V. J., Reichard, R. R., Przybelski, S. A., Lesnick, T. G., Schwarz, C. G., Senjem, M. L., Gunter, J. L., Parisi, J. E., Machulda, M. M., Vemuri, P., Mielke, M. M., Knopman, D. S., Petersen, R. C., Jack, C. R., Kantarci, O. H. & Kantarci, K., Apr 1 2020, In : Annals of neurology. 87, 4, p. 556-567 12 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
1 Scopus citations

Longitudinal amyloid-β PET in atypical Alzheimer's disease and frontotemporal lobar degeneration

Whitwell, J. L., Tosakulwong, N., Weigand, S. D., Graff-Radford, J., Duffy, J. R., Clark, H. M., Machulda, M. M., Botha, H., Utianski, R. L., Schwarz, C. G., Senjem, M. L., Strand, E. A., Ertekin-Taner, N., Jack, C. R., Lowe, V. J. & Josephs, K. A., 2020, In : Journal of Alzheimer's Disease. 74, 1, p. 377-389 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Longitudinal flortaucipir ([18F]AV-1451) PET uptake in semantic dementia

Utianski, R. L., Botha, H., Whitwell, J. L., Martin, P. R., Schwarz, C. G., Duffy, J. R., Clark, H. M., Spychalla, A. J., Senjem, M. L., Petersen, R. C., Knopman, D. S., Jack, C. R., Lowe, V. J. & Josephs, K. A., Aug 2020, In : Neurobiology of aging. 92, p. 135-140 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access

Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia

Petroi, D., Duffy, J. R., Borgert, A., Strand, E., Machulda, M. M., Senjem, M. L., Jack, C. R., Josephs, K. A. & Whitwell, J. L., May 2020, In : Brain and Language. 204, 104773.

Research output: Contribution to journalArticle

Preclinical Alzheimer's disease: a valid concept

Jack, C. R., Jan 2020, In : The Lancet Neurology. 19, 1, 1 p.

Research output: Contribution to journalLetter

Open Access
1 Scopus citations

Prevalence and Heterogeneity of Cerebrovascular Disease Imaging Lesions

Graff-Radford, J., Aakre, J. A., Knopman, D. S., Schwarz, C. G., Flemming, K. D., Rabinstein, A. A., Gunter, J. L., Ward, C. P., Zuk, S. M., Spychalla, A. J., Preboske, G. M., Petersen, R. C., Kantarci, K., Huston, J., Jack, C. R., Mielke, M. M. & Vemuri, P., Jun 2020, In : Mayo Clinic proceedings. 95, 6, p. 1195-1205 11 p.

Research output: Contribution to journalArticle

Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease

for the Dominantly Inherited Alzheimer Network, Aug 2020, In : Neurobiology of Disease. 142, 104960.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Tau-positron emission tomography correlates with neuropathology findings

Lowe, V. J., Lundt, E. S., Albertson, S. M., Min, H. K., Fang, P., Przybelski, S. A., Senjem, M. L., Schwarz, C. G., Kantarci, K., Boeve, B., Jones, D. T., Reichard, R. R., Tranovich, J. F., Hanna Al-Shaikh, F. S., Knopman, D. S., Jack, C. R., Dickson, D. W., Petersen, R. C. & Murray, M. E., Mar 1 2020, In : Alzheimer's and Dementia. 16, 3, p. 561-571 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

The genetic architecture of the human cerebral cortex

Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group, Mar 20 2020, In : Science. 367, 6484, aay6690.

Research output: Contribution to journalArticle

30 Scopus citations

The transformative potential of plasma phosphorylated tau

Jack, C. R., May 2020, In : The Lancet Neurology. 19, 5, p. 373-374 2 p.

Research output: Contribution to journalComment/debate

Trajectory of lobar atrophy in asymptomatic and symptomatic GRN mutation carriers: a longitudinal MRI study

Chen, Q., Boeve, B. F., Senjem, M., Tosakulwong, N., Lesnick, T., Brushaber, D., Dheel, C., Fields, J., Forsberg, L., Gavrilova, R., Gearhart, D., Graff-Radford, J., Graff-Radford, N., Jack, C. R., Jones, D., Knopman, D., Kremers, W. K., Lapid, M., Rademakers, R., Ramos, E. M. & 5 others, Syrjanen, J., Boxer, A. L., Rosen, H., Wszolek, Z. K. & Kantarci, K., Apr 2020, In : Neurobiology of aging. 88, p. 42-50 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Utility of FDG-PET in diagnosis of Alzheimer-related TDP-43 proteinopathy

Buciuc, M., Botha, H., Murray, M. E., Schwarz, C. G., Senjem, M. L., Jones, D. T., Knopman, D. S., Boeve, B. F., Petersen, R. C., Jack, C. R., Petrucelli, L., Parisi, J. E., Dickson, D. W., Lowe, V., Whitwell, J. L. & Josephs, K. A., Jul 7 2020, In : Neurology. 95, 1, p. e23-e34

Research output: Contribution to journalArticle

Witnessed apneas are associated with elevated tau-PET levels in cognitively unimpaired elderly

Carvalho, D. Z., StLouis, E. K., Schwarz, C. G., Lowe, V. J., Boeve, B. F., Przybelski, S. A., Reddy, A., Mielke, M. M., Knopman, D. S., Petersen, R. C., Jack, C. R. & Vemuri, P., Apr 28 2020, In : Neurology. 94, 17, p. E1793-E1802

Research output: Contribution to journalArticle

1 Scopus citations

β-Amyloid PET and neuropathology in dementia with Lewy bodies

Kantarci, K., Lowe, V. J., Chen, Q., Przybelski, S. A., Lesnick, T. G., Schwarz, C. G., Senjem, M. L., Gunter, J. L., Jack, C. R., Graff-Radford, J., Jones, D. T., Knopman, D. S., Graff-Radford, N., Ferman, T. J., Parisi, J. E., Dickson, D. W., Petersen, R. C., Boeve, B. F. & Murray, M. E., Jan 21 2020, In : Neurology. 94, 3, p. e282-e291

Research output: Contribution to journalArticle

Open Access
2019
5 Scopus citations

A blood-based signature of cerebrospinal fluid Aβ 1–42 status

Alzheimer’s Disease Metabolomics Consortium & Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 4163.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

A brief history of "Alzheimer disease": Multiple meanings separated by a common name

Knopman, D. S., Petersen, R. C. & Jack, C. R., May 28 2019, In : Neurology. 92, 22, p. 1053-1059 7 p.

Research output: Contribution to journalReview article

12 Scopus citations

A Comparison of Partial Volume Correction Techniques for Measuring Change in Serial Amyloid PET SUVR

Schwarz, C. G., Gunter, J. L., Lowe, V. J., Weigand, S., Vemuri, P., Senjem, M. L., Petersen, R. C., Knopman, D. S. & Jack, C. R., 2019, In : Journal of Alzheimer's Disease. 67, 1, p. 181-195 15 p.

Research output: Contribution to journalArticle

7 Scopus citations

A Joint Model for Predicting Structural and Functional Brain Health in Elderly Individuals

Varatharajah, Y., Saboo, K., Iyer, R., Przybelski, S., Schwarz, C., Petersen, R., Jack, C. & Vemuri, P., Nov 2019, Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019. Yoo, I., Bi, J. & Hu, X. T. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 1657-1664 8 p. 8983291. (Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Amyloid, Vascular, and Resilience Pathways Associated with Cognitive Aging

Vemuri, P., Lesnick, T. G., Knopman, D. S., Przybelski, S. A., Reid, R. I., Mielke, M. M., Graff-Radford, J., Lowe, V. J., Machulda, M. M., Petersen, R. C. & Jack, C. R., Dec 1 2019, In : Annals of neurology. 86, 6, p. 866-877 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
3 Scopus citations

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

the Dominantly Inherited Alzheimer Network (DIAN), Nov 1 2019, In : Nature Neuroscience. 22, 11, p. 1903-1912 10 p.

Research output: Contribution to journalArticle

24 Scopus citations