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  • Gregory James Gores
2020

An update on primary sclerosing cholangitis epidemiology, outcomes and quantification of alkaline phosphatase variability in a population-based cohort

Bakhshi, Z., Hilscher, M. B., Gores, G. J., Harmsen, W. S., Viehman, J. K., LaRusso, N. F., Gossard, A. A., Lazaridis, K. N., Lindor, K. D. & Eaton, J. E., May 1 2020, In : Journal of gastroenterology. 55, 5, p. 523-532 10 p.

Research output: Contribution to journalArticle

Changes in Liver Stiffness, Measured by Magnetic Resonance Elastography, Associated With Hepatic Decompensation in Patients With Primary Sclerosing Cholangitis

Eaton, J. E., Sen, A., Hoodeshenas, S., Schleck, C. D., Harmsen, W. S., Gores, G. J., LaRusso, N. F., Gossard, A. A., Lazaridis, K. N. & Venkatesh, S. K., Jun 2020, In : Clinical Gastroenterology and Hepatology. 18, 7, p. 1576-1583.e1

Research output: Contribution to journalArticle

2 Scopus citations

Cholangioscopy Biopsies Improve Detection of Cholangiocarcinoma When Combined with Cytology and FISH, but Not in Patients with PSC

Kaura, K., Sawas, T., Bazerbachi, F., Storm, A. C., Martin, J. A., Gores, G. J., Abu Dayyeh, B. K., Topazian, M. D., Levy, M. J., Petersen, B. T. & Chandrasekhara, V., May 1 2020, In : Digestive diseases and sciences. 65, 5, p. 1471-1478 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Diabetes Is Associated With Increased Risk of Hepatocellular Carcinoma in Patients With Cirrhosis From Nonalcoholic Fatty Liver Disease

Yang, J. D., Ahmed, F., Mara, K. C., Addissie, B. D., Allen, A. M., Gores, G. J. & Roberts, L. R., Mar 1 2020, In : Hepatology. 71, 3, p. 907-916 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Diet Mimicking “Fast Food” Causes Structural Changes to the Retina Relevant to Age-Related Macular Degeneration

Roddy, G. W., Rosa, R. H., Viker, K. B., Holman, B. H., Hann, C. R., Krishnan, A., Gores, G. J., Bakri, S. J. & Fautsch, M. P., Jun 2 2020, In : Current Eye Research. 45, 6, p. 726-732 7 p.

Research output: Contribution to journalArticle

Endoscopic Ultrasound/Fine Needle Aspiration Is Effective for Lymph Node Staging in Patients With Cholangiocarcinoma

Malikowski, T., Levy, M. J., Gleeson, F. C., Storm, A. C., Vargas, E. J., Topazian, M. D., Abu Dayyeh, B. K., Iyer, P. G., Rajan, E., Gores, G. J., Roberts, L. R. & Chandrasekhara, V., 2020, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Hepatocyte apoptosis is tumor promoting in murine nonalcoholic steatohepatitis

Hirsova, P., Bohm, F., Dohnalkova, E., Nozickova, B., Heikenwalder, M., Gores, G. J. & Weber, A., Feb 1 2020, In : Cell Death and Disease. 11, 2, 80.

Research output: Contribution to journalArticle

Open Access

Living Donor Liver Transplantation for Perihilar Cholangiocarcinoma: Outcomes and Complications

Tan, E. K., Rosen, C. B., Heimbach, J. K., Gores, G. J., Zamora-Valdes, D. & Taner, T., 2020, (Accepted/In press) In : Journal of the American College of Surgeons.

Research output: Contribution to journalArticle

1 Scopus citations

Lytic cell death in metabolic liver disease

Gautheron, J., Gores, G. J. & Rodrigues, C. M. P., 2020, (Accepted/In press) In : Journal of hepatology.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Mistiming Death: Modeling the Time-Domain Variability of Tumor Apoptosis and Implications for Molecular Imaging of Cell Death

Gammon, S. T., Engel, B. J., Gores, G. J., Cressman, E., Piwnica-Worms, D. & Millward, S. W., 2020, (Accepted/In press) In : Molecular Imaging and Biology.

Research output: Contribution to journalArticle

Phenotypic, Transcriptional, and Functional Analysis of Liver Mesenchymal Stromal Cells and Their Immunomodulatory Properties

Taner, T., Abrol, N., Park, W. D., Hansen, M. J., Gustafson, M. P., Lerman, L. O., van Wijnen, A. J., Dietz, A. B., Gores, G. J. & Stegall, M. D., Apr 1 2020, In : Liver Transplantation. 26, 4, p. 549-563 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning

Eaton, J. E., Vesterhus, M., McCauley, B. M., Atkinson, E. J., Schlicht, E. M., Juran, B. D., Gossard, A. A., LaRusso, N. F., Gores, G. J., Karlsen, T. H. & Lazaridis, K. N., Jan 1 2020, In : Hepatology. 71, 1, p. 214-224 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Systemic therapies for intrahepatic cholangiocarcinoma

Kelley, R. K., Bridgewater, J., Gores, G. J. & Zhu, A. X., Feb 2020, In : Journal of hepatology. 72, 2, p. 353-363 11 p.

Research output: Contribution to journalReview article

5 Scopus citations

The Emerging Role of Macrophages in Chronic Cholangiopathies Featuring Biliary Fibrosis: An Attractive Therapeutic Target for Orphan Diseases

Cadamuro, M., Girardi, N., Gores, G. J., Strazzabosco, M. & Fabris, L., Apr 21 2020, In : Frontiers in Medicine. 7, 115.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

The Spectrum of Reactive Cholangiocytes in Primary Sclerosing Cholangitis

Guicciardi, M. E., Trussoni, C. E., LaRusso, N. F. & Gores, G. J., Feb 1 2020, In : Hepatology. 71, 2, p. 741-748 8 p.

Research output: Contribution to journalReview article

1 Scopus citations

The Two Faces of Relaxin in Cancer: Antitumor or Protumor?

Rizvi, S. & Gores, G. J., Mar 1 2020, In : Hepatology. 71, 3, p. 1117-1119 3 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Receptor Deficiency Promotes the Ductular Reaction, Macrophage Accumulation, and Hepatic Fibrosis in the Abcb4−/− Mouse

Krishnan, A., Katsumi, T., Guicciardi, M. E., Azad, A. I., Ozturk, N. B., Trussoni, C. E. & Gores, G. J., Jun 2020, In : American Journal of Pathology. 190, 6, p. 1284-1297 14 p.

Research output: Contribution to journalArticle

2019

Activated cholangiocytes release macrophage-polarizing extracellular vesicles bearing the DAMP S100A11

Katsumi, T., Guicciardi, M. E., Azad, A., Bronk, S. F., Krishnan, A. & Gores, G. J., Jan 1 2019, In : American Journal of Physiology - Cell Physiology. 317, 4, p. C788-C799

Research output: Contribution to journalArticle

3 Scopus citations

A global view of hepatocellular carcinoma: trends, risk, prevention and management

Yang, J. D., Hainaut, P., Gores, G. J., Amadou, A., Plymoth, A. & Roberts, L. R., Jan 1 2019, (Accepted/In press) In : Nature Reviews Gastroenterology and Hepatology.

Research output: Contribution to journalReview article

101 Scopus citations

Animal models of cholangiocarcinoma

Loeuillard, E., Fischbach, S. R., Gores, G. J. & Rizvi, S., May 1 2019, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 5, p. 982-992 11 p.

Research output: Contribution to journalReview article

10 Scopus citations

Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice

Aziz, K., Limzerwala, J. F., Sturmlechner, I., Hurley, E., Zhang, C., Jeganathan, K. B., Nelson, G., Bronk, S., Fierro Velasco, R. O., van Deursen, E. J., O'Brien, D. R., Kocher, J. P. A., Youssef, S. A., van Ree, J. H., de Bruin, A., van den Bos, H., Spierings, D. C. J., Foijer, F., van de Sluis, B., Roberts, L. R. & 3 others, Gores, G. J., Li, H. & van Deursen, J. M., Jul 2019, In : Gastroenterology. 157, 1, p. 210-226.e12

Research output: Contribution to journalArticle

7 Scopus citations

Cholangiocyte pathobiology

Banales, J. M., Huebert, R. C., Karlsen, T., Strazzabosco, M., LaRusso, N. F. & Gores, G. J., May 1 2019, In : Nature Reviews Gastroenterology and Hepatology. 16, 5, p. 269-281 13 p.

Research output: Contribution to journalReview article

26 Scopus citations

GALAD score for hepatocellular carcinoma detection in comparison with liver ultrasound and proposal of Galadus score

Yang, J. D., Addissie, B. D., Mara, K. C., Harmsen, W. S., Dai, J., Zhang, N., Wongjarupong, N., Ali, H. M., Ali, H. A., Hassan, F. A., Lavu, S., Cvinar, J. L., Giama, N. H., Moser, C. D., Miyabe, K., Allotey, L. K., Algeciras-Schimnich, A., Theobald, J. P., Ward, M. M., Nguyen, M. H. & 11 others, Befeler, A. S., Reddy, K. R., Schwartz, M., Harnois, D. M., Yamada, H., Srivastava, S., Rinaudo, J. A., Gores, G. J., Feng, Z., Marrero, J. A. & Roberts, L. R., Mar 2019, In : Cancer Epidemiology Biomarkers and Prevention. 28, 3, p. 531-538 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Intrahepatic Cholangiocarcinoma: Continuing Challenges and Translational Advances

Sirica, A. E., Gores, G. J., Groopman, J. D., Selaru, F. M., Strazzabosco, M., Wei Wang, X. & Zhu, A. X., Apr 2019, In : Hepatology. 69, 4, p. 1803-1815 13 p.

Research output: Contribution to journalReview article

22 Scopus citations
1 Scopus citations

The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1

O'Hara, S. P., Splinter, P. L., Trussoni, C. E., Guicciardi, M. E., Splinter, N. P., Al Suraih, M. S., Nasser-Ghodsi, N., Stollenwerk, D., Gores, G. J. & LaRusso, N. F., Dec 6 2019, In : Journal of Biological Chemistry. 294, 49, p. 18698-18713 16 p.

Research output: Contribution to journalArticle

1 Scopus citations

Translation to Practice: Accelerating the Cycle of Innovation to Impact

Anderson, J. R., Chung, T. D. Y., Clark, L., Weis, J. A., Danielsen, A. J., Khosla, S., Gores, G. J. & Badley, A. D., Jan 1 2019, In : Mayo Clinic proceedings.

Research output: Contribution to journalReview article

1 Scopus citations

YAP and the Hippo pathway in cholangiocarcinoma

Sugihara, T., Isomoto, H., Gores, G. & Smoot, R., Jun 5 2019, In : Journal of gastroenterology. 54, 6, p. 485-491 7 p.

Research output: Contribution to journalReview article

Open Access
6 Scopus citations
2018

cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation

Brunt, E., Aishima, S., Clavien, P. A., Fowler, K., Goodman, Z., Gores, G., Gouw, A., Kagen, A., Klimstra, D., Komuta, M., Kondo, F., Miksad, R., Nakano, M., Nakanuma, Y., Ng, I., Paradis, V., Nyun Park, Y., Quaglia, A., Roncalli, M., Roskams, T. & 14 others, Sakamoto, M., Saxena, R., Sempoux, C., Sirlin, C., Stueck, A., Thung, S., Tsui, W. M. S., Wang, X. W., Wee, A., Yano, H., Yeh, M., Zen, Y., Zucman-Rossi, J. & Theise, N., Jul 2018, In : Hepatology. 68, 1, p. 113-126 14 p.

Research output: Contribution to journalArticle

65 Scopus citations

Cholangiocarcinoma-evolving concepts and therapeutic strategies

Rizvi, S., Khan, S. A., Hallemeier, C., Kelley, R. K. & Gores, G. J., Feb 1 2018, In : Nature Reviews Clinical Oncology. 15, 2, p. 95-111 17 p.

Research output: Contribution to journalReview article

177 Scopus citations

Does cirrhosis associated with well controlled viral hepatitis confer a risk for extrahepatic cancer?

Yang, J. D. & Gores, G. J., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Emerging Technologies for the Diagnosis of Perihilar Cholangiocarcinoma

Rizvi, S., Eaton, J., Yang, J. D., Chandrasekhara, V. & Gores, G. J., May 1 2018, In : Seminars in Liver Disease. 38, 2, p. 160-169 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Fibroblast Growth Factor Receptor Inhibition for Cholangiocarcinoma: Looking Through a Door Half-Opened

Rizvi, S. & Gores, G. J., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Fibroblast growth factor receptor inhibition induces loss of matrix MCL1 and necrosis in cholangiocarcinoma

Kabashima, A., Hirsova, P., Bronk, S. F., Hernandez, M. C., Truty, M., Rizvi, S., Kaufmann, S. H. & Gores, G. J., Jan 1 2018, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

4 Scopus citations

Impact of surveillance for hepatocellular carcinoma on survival in patients with compensated cirrhosis

Yang, J. D., Mannalithara, A., Piscitello, A. J., Kisiel, J. B., Gores, G. J., Roberts, L. R. & Kim, W. R., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

16 Scopus citations

Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice

Guicciardi, M. E., Trussoni, C. E., Krishnan, A., Bronk, S. F., Lorenzo Pisarello, M. J., O'Hara, S. P., Splinter, P. L., Gao, Y., Vig, P., Revzin, A., La Russo, N. F. & Gores, G. J., Jan 1 2018, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

22 Scopus citations

Non-alcoholic steatohepatitis pathogenesis: Sublethal hepatocyte injury as a driver of liver inflammation

Ibrahim, S. C., Hirsova, P. & Gores, G. J., May 1 2018, In : Gut. 67, 5, p. 963-972 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice

Moncsek, A., Al-Suraih, M. S., Trussoni, C. E., O'Hara, S. P., Splinter, P. L., Zuber, C., Patsenker, E., Valli, P. V., Fingas, C. D., Weber, A., Zhu, Y., Tchkonia, T., Kirkland, J. L., Gores, G. J., Müllhaupt, B., La Russo, N. F. & Mertens, J. C., Jan 1 2018, In : Hepatology. 67, 1, p. 247-259 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis

Puri, P., Liangpunsakul, S., Christensen, J. E., Shah, V., Kamath, P. S., Gores, G. J., Walker, S., Comerford, M., Katz, B., Borst, A., Yu, Q., Kumar, D. P., Mirshahi, F., Radaeva, S., Chalasani, N. P., Crabb, D. W. & Sanyal, A. J., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

36 Scopus citations

YAP-associated chromosomal instability and cholangiocarcinoma in mice

Rizvi, S., Fischbach, S. R., Bronk, S. F., Hirsova, P., Krishnan, A., Dhanasekaran, R., Smadbeck, J. B., Smoot, R. L., Vasmatzis, G. & Gores, G. J., 2018, In : Oncotarget. 9, 5, p. 5892-5905 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

YAP tyrosine phosphorylation and nuclear localization in cholangiocarcinoma cells are regulated by LCK and independent of LATS activity

Sugihara, T., Werneburg, N. W., Hernandez, M. C., Yang, L., Kabashima, A., Hirsova, P., Yohanathan, L., Sosa, C., Truty, M., Vasmatzis, G., Gores, G. J. & Smoot, R., Oct 1 2018, In : Molecular Cancer Research. 16, 10, p. 1556-1567 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2017

A longitudinal study of whole body, tissue, and cellular physiology in a mouse model of fibrosing NASH with high fidelity to the human condition

Krishnan, A., Abdullah, T. S., Mounajjed, T., Hartono, S., McConico, A., White, T., LeBrasseur, N., Lanza, I., Nair, S., Gores, G. & Charlton, M. R., Jun 8 2017, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 312, 6, p. G666-G680

Research output: Contribution to journalArticle

21 Scopus citations

Anti-GP2 IgA: A biomarker for disease severity and/or cholangiocarcinoma in primary sclerosing cholangitis?

Rizvi, S., Yang, J. D. & Gores, G. J., Jan 1 2017, In : Gut. 66, 1, p. 4-5 2 p.

Research output: Contribution to journalComment/debate

Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice

Guicciardi, M. E., Krishnan, A., Bronk, S. F., Hirsova, P., Griffith, T. S. & Gores, G. J., Jan 5 2017, In : Cell Death and Disease. 8, 1, e2535.

Research output: Contribution to journalArticle

5 Scopus citations

Characteristics, management, and outcomes of patients with hepatocellular carcinoma in Africa: a multicountry observational study from the Africa Liver Cancer Consortium

Yang, J. D., Mohamed, E. A., Aziz, A. O. A., Shousha, H. I., Hashem, M. B., Nabeel, M. M., Abdelmaksoud, A. H., Elbaz, T. M., Afihene, M. Y., Duduyemi, B. M., Ayawin, J. P., Gyedu, A., Lohouès-Kouacou, M. J., Ndam, A. W. N., Moustafa, E. F., Hassany, S. M., Moussa, A. M., Ugiagbe, R. A., Omuemu, C. E., Anthony, R. & 37 others, Palmer, D., Nyanga, A. F., Malu, A. O., Obekpa, S., Abdo, A. E., Siddig, A. I., Mudawi, H. M. Y., Okonkwo, U., Kooffreh-Ada, M., Awuku, Y. A., Nartey, Y. A., Abbew, E. T., Awuku, N. A., Otegbayo, J. A., Akande, K. O., Desalegn, H. M., Omonisi, A. E., Ajayi, A. O., Okeke, E. N., Duguru, M. J., Davwar, P. M., Okorie, M. C., Mustapha, S., Debes, J. D., Ocama, P., Lesi, O. A., Odeghe, E., Bello, R., Onyekwere, C., Ekere, F., Igetei, R., Mah'moud, M. A., Addissie, B., Ali, H. M., Gores, G. J., Topazian, M. D. & Roberts, L. R., Feb 1 2017, In : The Lancet Gastroenterology and Hepatology. 2, 2, p. 103-111 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Cholangiocarcinoma: Disease pathogenesis and new treatment paradigms

Gores, G. J. & Blechacz, B., Jan 1 2017, Biliary Disease: From Science to Clinic. Springer International Publishing, p. 219-228 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis

Loarca, L., De Assuncao, T. M., Jalan-Sakrikar, N., Bronk, S., Krishnan, A., Huang, B., Morton, L., Trussoni, C., Bonilla, L. M., Krueger, E., O'Hara, S., Splinter, P., Shi, G., Pisarello, M. J. L., Gores, G. J., Huebert, R. C. & La Russo, N. F., Nov 1 2017, In : Laboratory Investigation. 97, 11, p. 1385-1396 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Emerging molecular therapeutic targets for cholangiocarcinoma

Rizvi, S. & Gores, G. J., Jan 5 2017, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

49 Scopus citations

Emerging pharmacologic therapies for primary sclerosing cholangitis

Cheung, A. C., Lazaridis, K. N., La Russo, N. F. & Gores, G. J., Mar 2 2017, (Accepted/In press) In : Current Opinion in Gastroenterology.

Research output: Contribution to journalArticle

6 Scopus citations