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  • Sundeep Khosla
2020

Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes

Eckhardt, B. A., Rowsey, J. L., Thicke, B. S., Fraser, D. G., O'Grady, K. L., Bondar, O. P., Hines, J. M., Singh, R. J., Thoreson, A. R., Rakshit, K., Lagnado, A. B., Passos, J. F., Vella, A., Matveyenko, A. V., Khosla, S., Monroe, D. G. & Farr, J. N., May 7 2020, In : JCI Insight. 5, 9, e135236.

Research output: Contribution to journalArticle

Open Access

Aspirin and fracture risk: A systematic review and exploratory meta-analysis of observational studies

Barker, A. L., Soh, S. E., Sanders, K. M., Pasco, J., Khosla, S., Ebeling, P. R., Ward, S. A., Peeters, G., Talevski, J., Cumming, R. G., Seeman, E. & McNeil, J. J., Feb 20 2020, In : BMJ open. 10, 2, 026876.

Research output: Contribution to journalArticle

Open Access

Biomechanical Computed Tomography analysis (BCT) for clinical assessment of osteoporosis

Keaveny, T. M., Clarke, B. L., Cosman, F., Orwoll, E. S., Siris, E. S., Khosla, S. & Bouxsein, M. L., Jun 1 2020, In : Osteoporosis International. 31, 6, p. 1025-1048 24 p.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Corrigendum to ‘Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease’ (EBioMedicine (2019) 47 (446–456), (S2352396419305912), (10.1016/j.ebiom.2019.08.069))

Hickson, L. T. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., Kellogg, T. A., Khosla, S., Koerber, D. M., Lagnado, A. B., Lawson, D. K., LeBrasseur, N. K., Lerman, L. O., McDonald, K. M., McKenzie, T. J., Passos, J. F. & 18 others, Pignolo, R. J., Pirtskhalava, T., Saadiq, I. M., Schaefer, K. K., Textor, S. C., Victorelli, S. G., Volkman, T. L., Xue, A., Wentworth, M. A., Wissler Gerdes, E. O., Allison, D. B., Dickinson, S. L., Ejima, K., Atkinson, E. J., Lenburg, M., Zhu, Y., Tchkonia, T. & Kirkland, J. L., Feb 2020, In : EBioMedicine. 52, 102595.

Research output: Contribution to journalComment/debate

Open Access
4 Scopus citations

Early effects of androgen deprivation on bone and mineral homeostasis in adult men: a prospective cohort study

Khalil, R., Antonio, L., Laurent, M. R., David, K., Kim, N. R., Evenepoel, P., Eisenhauer, A., Heuser, A., Cavalier, E., Khosla, S., Claessens, F., Vanderschueren, D. & Decallonne, B., Aug 1 2020, In : European journal of endocrinology. 183, 2, p. 181-189 9 p.

Research output: Contribution to journalArticle

Hip load capacity and yield load in men and women of all ages

Keyak, J. H., Kaneko, T. S., Khosla, S., Amin, S., Atkinson, E. J., Lang, T. F. & Sibonga, J. D., Aug 2020, In : Bone. 137, 115321.

Research output: Contribution to journalArticle

Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Weivoda, M. M., Chew, C. K., Monroe, D. G., Farr, J. N., Atkinson, E. J., Geske, J. R., Eckhardt, B., Thicke, B., Ruan, M., Tweed, A. J., McCready, L. K., Rizza, R. A., Matveyenko, A., Kassem, M., Andersen, T. L., Vella, A., Drake, M. T., Clarke, B. L., Oursler, M. J. & Khosla, S., Dec 1 2020, In : Nature communications. 11, 1, 87.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

LPS-induced premature osteocyte senescence: Implications in inflammatory alveolar bone loss and periodontal disease pathogenesis

Aquino-Martinez, R., Rowsey, J. L., Fraser, D. G., Eckhardt, B. A., Khosla, S., Farr, J. N. & Monroe, D. G., Mar 2020, In : Bone. 132, 115220.

Research output: Contribution to journalArticle

1 Scopus citations

Male mice with elevated C-type natriuretic peptide-dependent guanylyl cyclase-B activity have increased osteoblasts, bone mass and bone strength

Robinson, J. W., Blixt, N. C., Norton, A., Mansky, K. C., Ye, Z., Aparicio, C., Wagner, B. M., Benton, A. M., Warren, G. L., Khosla, S., Gaddy, D., Suva, L. J. & Potter, L. R., Jun 2020, In : Bone. 135, 115320.

Research output: Contribution to journalArticle

1 Scopus citations

Managing fragility fractures during the COVID-19 pandemic

Napoli, N., Elderkin, A. L., Kiel, D. P. & Khosla, S., Jan 1 2020, (Accepted/In press) In : Nature Reviews Endocrinology.

Research output: Contribution to journalComment/debate

Open Access
1 Scopus citations

Posterior single-stepping thresholds are prospectively related to falls in older women

Crenshaw, J. R., Bernhardt, K. A., Atkinson, E. J., Achenbach, S. J., Khosla, S., Amin, S. & Kaufman, K. R., Jan 1 2020, (Accepted/In press) In : Aging Clinical and Experimental Research.

Research output: Contribution to journalArticle

Reducing Senescent Cell Burden in Aging and Disease

Pignolo, R. J., Passos, J. F., Khosla, S., Tchkonia, T. & Kirkland, J. L., 2020, (Accepted/In press) In : Trends in Molecular Medicine.

Research output: Contribution to journalReview article

Secondary Fracture Prevention: Consensus Clinical Recommendations From a Multistakeholder Coalition

Conley, R. B., Adib, G., Adler, R. A., Åkesson, K. E., Alexander, I. M., Amenta, K. C., Blank, R. D., Brox, W. T., Carmody, E. E., Chapman-Novakofski, K., Clarke, B. L., Cody, K. M., Cooper, C., Crandall, C. J., Dirschl, D. R., Eagen, T. J., Elderkin, A. L., Fujita, M., Greenspan, S. L., Halbout, P. & 26 others, Hochberg, M. C., Javaid, M., Jeray, K. J., Kearns, A. E., King, T., Koinis, T. F., Koontz, J. S., Kužma, M., Lindsey, C., Lorentzon, M., Lyritis, G. P., Michaud, L. B., Miciano, A., Morin, S. N., Mujahid, N., Napoli, N., Olenginski, T. P., Puzas, J. E., Rizou, S., Rosen, C. J., Saag, K., Thompson, E., Tosi, L. L., Tracer, H., Khosla, S. & Kiel, D. P., May 1 2020, In : Orthopaedic Nursing. 39, 3, p. 145-161 17 p.

Research output: Contribution to journalArticle

Secondary Fracture Prevention: Consensus Clinical Recommendations from a Multistakeholder Coalition

Conley, R. B., Adib, G., Adler, R. A., Åkesson, K. E., Alexander, I. M., Amenta, K. C., Blank, R. D., Brox, W. T., Carmody, E. E., Chapman-Novakofski, K., Clarke, B. L., Cody, K. M., Cooper, C., Crandall, C. J., Dirschl, D. R., Eagen, T. J., Elderkin, A. L., Fujita, M., Greenspan, S. L., Halbout, P. & 26 others, Hochberg, M. C., Javaid, M., Jeray, K. J., Kearns, A. E., King, T., Koinis, T. F., Koontz, J. S., Kužma, M., Lindsey, C., Lorentzon, M., Lyritis, G. P., Michaud, L. B., Miciano, A., Morin, S. N., Mujahid, N., Napoli, N., Olenginski, T. P., Puzas, J. E., Rizou, S., Rosen, C. J., Saag, K., Thompson, E., Tosi, L. L., Tracer, H., Khosla, S. & Kiel, D. P., Apr 1 2020, In : Journal of orthopaedic trauma. 34, 4, p. e125-e141

Research output: Contribution to journalArticle

1 Scopus citations

Secondary Fracture Prevention: Consensus Clinical Recommendations from a Multistakeholder Coalition

Conley, R. B., Adib, G., Adler, R. A., Åkesson, K. E., Alexander, I. M., Amenta, K. C., Blank, R. D., Brox, W. T., Carmody, E. E., Chapman-Novakofski, K., Clarke, B. L., Cody, K. M., Cooper, C., Crandall, C. J., Dirschl, D. R., Eagen, T. J., Elderkin, A. L., Fujita, M., Greenspan, S. L., Halbout, P. & 26 others, Hochberg, M. C., Javaid, M., Jeray, K. J., Kearns, A. E., King, T., Koinis, T. F., Koontz, J. S., Kužma, M., Lindsey, C., Lorentzon, M., Lyritis, G. P., Michaud, L. B., Miciano, A., Morin, S. N., Mujahid, N., Napoli, N., Olenginski, T. P., Puzas, J. E., Rizou, S., Rosen, C. J., Saag, K., Thompson, E., Tosi, L. L., Tracer, H., Khosla, S. & Kiel, D. P., Jan 1 2020, In : Journal of Bone and Mineral Research. 35, 1, p. 36-52 17 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss

Chandra, A., Lagnado, A. B., Farr, J. N., Monroe, D. G., Park, S., Hachfeld, C., Tchkonia, T., Kirkland, J. L., Khosla, S., Passos, J. F. & Pignolo, R. J., Jun 1 2020, In : Journal of Bone and Mineral Research. 35, 6, p. 1119-1131 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

The impact of mild autonomous cortisol secretion on bone turnover markers

Athimulam, S., Delivanis, D., Thomas, M., Young, W. F., Khosla, S., Drake, M. T. & Bancos, I., May 1 2020, In : Journal of Clinical Endocrinology and Metabolism. 105, 5, dgz148.

Research output: Contribution to journalArticle

1 Scopus citations

The microbiome adds to the complexity of parathyroid hormone action on bone

Khosla, S., Apr 1 2020, In : Journal of Clinical Investigation. 130, 4, p. 1615-1617 3 p.

Research output: Contribution to journalReview article

The role of cellular senescence in ageing and endocrine disease

Khosla, S., Farr, J. N., Tchkonia, T. & Kirkland, J. L., May 1 2020, In : Nature Reviews Endocrinology. 16, 5, p. 263-275 13 p.

Research output: Contribution to journalReview article

5 Scopus citations

Unsupervised machine learning for the discovery of latent disease clusters and patient subgroups using electronic health records

Wang, Y., Zhao, Y., Therneau, T. M., Atkinson, E. J., Tafti, A. P., Zhang, N., Amin, S., Limper, A. H., Khosla, S. & Liu, H., Feb 2020, In : Journal of Biomedical Informatics. 102, 103364.

Research output: Contribution to journalArticle

1 Scopus citations
2019
1 Scopus citations

Cellular senescence in bone

Farr, J. N. & Khosla, S., Apr 2019, In : Bone. 121, p. 121-133 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Circulating Osteogenic Progenitor Cells in Mild, Moderate, and Severe Aortic Valve Stenosis

Al-Hijji, M., Narula, N., Go, J. L., Khosla, S., Sarano, M. E., Loeffler, D., Lennon, R., Lerman, L. O. & Lerman, A., Apr 1 2019, In : Mayo Clinic proceedings. 94, 4, p. 652-659 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study

Samelson, E. J., Broe, K. E., Xu, H., Yang, L., Boyd, S., Biver, E., Szulc, P., Adachi, J., Amin, S., Atkinson, E., Berger, C., Burt, L., Chapurlat, R., Chevalley, T., Ferrari, S., Goltzman, D., Hanley, D. A., Hannan, M. T., Khosla, S., Liu, C. T. & 13 others, Lorentzon, M., Mellstrom, D., Merle, B., Nethander, M., Rizzoli, R., Sornay-Rendu, E., Van Rietbergen, B., Sundh, D., Wong, A. K. O., Ohlsson, C., Demissie, S., Kiel, D. P. & Bouxsein, M. L., Jan 2019, In : The Lancet Diabetes and Endocrinology. 7, 1, p. 34-43 10 p.

Research output: Contribution to journalArticle

49 Scopus citations
Open Access
1 Scopus citations

Estrogens and progestins

Monroe, D. G. & Khosla, S., Jan 1 2019, Principles of Bone Biology. Elsevier, p. 827-837 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans

Farr, J. N., Rowsey, J. L., Eckhardt, B. A., Thicke, B. S., Fraser, D. G., Tchkonia, T., Kirkland, J. L., Monroe, D. G. & Khosla, S., Jan 1 2019, In : Journal of Bone and Mineral Research. 34, 8, p. 1407-1418 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Is It Time to Stop (or Pause) Vertebral Augmentation?

Clarke, B. L. & Khosla, S., Jan 2019, In : Journal of Bone and Mineral Research. 34, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

2 Scopus citations

miR-219a-5p Regulates Rorβ During Osteoblast Differentiation and in Age-related Bone Loss

Aquino-Martinez, R., Farr, J. N., Weivoda, M. M., Negley, B. A., Onken, J. L., Thicke, B. S., Fulcer, M. M., Fraser, D. G., van Wijnen, A. J., Khosla, S. & Monroe, D. G., Jan 2019, In : Journal of Bone and Mineral Research. 34, 1, p. 135-144 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Personalising osteoporosis treatment for patients at high risk of fracture

Khosla, S., Oct 1 2019, In : The Lancet Diabetes and Endocrinology. 7, 10, p. 739-741 3 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. T. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., Kellogg, T. A., Khosla, S., Koerber, D. M., Lagnado, A. B., Lawson, D. K., LeBrasseur, N. K., Lerman, L. O., McDonald, K. M., McKenzie, T. J., Passos, J. F. & 13 others, Pignolo, R. J., Pirtskhalava, T., Saadiq, I. M., Schaefer, K. K., Textor, S. C., Victorelli, S. G., Volkman, T. L., Xue, A., Wentworth, M. A., Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T. & Kirkland, J. L., Sep 2019, In : EBioMedicine. 47, p. 446-456 11 p.

Research output: Contribution to journalArticle

Open Access
53 Scopus citations

Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials

Jankowski, C. M., Wolfe, P., Schmiege, S. J., Nair, K. S., Khosla, S., Jensen, M., von Muhlen, D., Laughlin, G. A., Kritz-Silverstein, D., Bergstrom, J., Bettencourt, R., Weiss, E. P., Villareal, D. T. & Kohrt, W. M., Feb 1 2019, In : Clinical Endocrinology. 90, 2, p. 293-300 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Skeletal considerations in the medical treatment of transgender people

Khosla, S. & Davidge-Pitts, C., Dec 2019, In : The Lancet Diabetes and Endocrinology. 7, 12, p. 893-895 3 p.

Research output: Contribution to journalComment/debate

Translation to Practice: Accelerating the Cycle of Innovation to Impact

Anderson, J. R., Chung, T. D. Y., Clark, L., Weis, J. A., Danielsen, A. J., Khosla, S., Gores, G. J. & Badley, A. D., Jan 1 2019, In : Mayo Clinic proceedings.

Research output: Contribution to journalReview article

1 Scopus citations

Virtual supersampling as post-processing step preserves the trabecular bone morphometry in human peripheral quantitative computed tomography scans

Schulte, F. A., Christen, P., Badilatti, S. D., Parkinson, I., Khosla, S., Goldhahn, J. & Müller, R., Feb 2019, In : PloS one. 14, 2, e0212280.

Research output: Contribution to journalArticle

Open Access
2018

Advancing the Science of Healthcare Service Delivery: The NHLBI Corporate Healthcare Leaders' Panel

Sampson, U. K. A., McGlynn, E. A., Perlin, J. B., Frisse, M. E., Arnold, S. B., Benz, E. J., Brennan, T., Briss, P., Beeuwkes Buntin, M. J., Khosla, S., King, R. G., Kuntz, R., Leider, H., Ling, S. M., Macrae, J., Murray, R., Thrailkill, E., Wager, C., Witchey, D. & Jacobson, H. R., Jan 1 2018, (Accepted/In press) In : Global Heart.

Research output: Contribution to journalArticle

Aging, Obesity, and the Incidence of Diverticulitis: A Population-Based Study

Lee, T. H., Setty, P. T., Parthasarathy, G., Bailey, K. R., Wood-Wentz, C. M., Fletcher, J. G., Takahashi, N., Khosla, S., Moynagh, M. R., Zinsmeister, A. R. & Bharucha, A. E., Sep 1 2018, In : Mayo Clinic Proceedings. 93, 9, p. 1256-1265 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Evaluation of cross-sectional and longitudinal changes in volumetric bone mineral density in postmenopausal women using single- versus dual-energy quantitative computed tomography

Sfeir, J. G., Drake, M. M., Atkinson, E. J., Achenbach, S. J., Camp, J. J., Tweed, A. J., McCready, L. K., Yu, L., Adkins, M. C., Amin, S. & Khosla, S., Jul 1 2018, In : Bone. 112, p. 145-152 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Factors associated with proximal femur fracture determined in a large cadaveric cohort

Dragomir Daescu, M. D., Rossman, T. L., Rezaei, A., Carlson, K. D., Kallmes, D. F., Skinner, J. A., Khosla, S. & Amin, S., Nov 1 2018, In : Bone. 116, p. 196-202 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Glycemic Control and Bone Turnover in Older Mexican Americans with Type 2 Diabetes

Rianon, N. J., Smith, S. M., Lee, M. J., Pervin, H., Musgrave, P., Watt, G. P., Nader, S., Khosla, S., Ambrose, C. G., McCormick, J. B. & Fisher-Hoch, S. P., 2018, In : Journal of Osteoporosis. 2018, 7153021.

Research output: Contribution to journalArticle

1 Scopus citations
33 Scopus citations

Net ankle quasi-stiffness is influenced by walking speed but not age for older adult women

Collins, J. D., Arch, E. S., Crenshaw, J. R., Bernhardt, K. A., Khosla, S., Amin, S. & Kaufman, K. R., May 1 2018, In : Gait and Posture. 62, p. 311-316 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Osteoporosis and Hip Fracture Risk From Routine Computed Tomography Scans: The Fracture, Osteoporosis, and CT Utilization Study (FOCUS)

Adams, A. L., Fischer, H., Kopperdahl, D. L., Lee, D. C., Black, D. M., Bouxsein, M. L., Fatemi, S., Khosla, S., Orwoll, E. S., Siris, E. S. & Keaveny, T. M., Jul 2018, In : Journal of Bone and Mineral Research. 33, 7, p. 1291-1301 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Osteoprotection Through the Deletion of the Transcription Factor Rorβ in Mice

Farr, J., Weivoda, M., Nicks, K. M., Fraser, D. G., Negley, B. A., Onken, J. L., Thicke, B. S., Ruan, M., Liu, H., Forrest, D., Hawse, J. R., Khosla, S. & Monroe, D. G., Apr 1 2018, In : Journal of Bone and Mineral Research. 33, 4, p. 720-731 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Proceedings of the 2018 Santa Fe Bone Symposium: Advances in the Management of Osteoporosis

Lewiecki, E. M., Bilezikian, J. P., Giangregorio, L., Greenspan, S. L., Khosla, S., Kostenuik, P., Krohn, K., McClung, M. R., Miller, P. D. & Pacifici, R., Jan 1 2018, (Accepted/In press) In : Journal of Clinical Densitometry.

Research output: Contribution to journalArticle

2 Scopus citations

Regulation of bone metabolism by sex steroids

Khosla, S. & Monroe, D. G., Jan 2018, In : Cold Spring Harbor Perspectives in Medicine. 8, 1, a031211.

Research output: Contribution to journalReview article

29 Scopus citations

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J. & 13 others, Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L., Aug 1 2018, In : Nature Medicine. 24, 8, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

290 Scopus citations

Sex steroids and the pathogenesis of osteoporosis

Drake, M. M. & Khosla, S., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 412-418 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Sympathetic β1-adrenergic signaling contributes to regulation of human bone metabolism

Khosla, S., Drake, M. M., Volkman, T. L., Thicke, B. S., Achenbach, S. J., Atkinson, E. J., Joyner, M. J., Rosen, C. J., Monroe, D. G. & Farr, J., Nov 1 2018, In : The Journal of clinical investigation. 128, 11, p. 4832-4842 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

The relationships between compensatory stepping thresholds and measures of gait, standing postural control, strength, and balance confidence in older women

Crenshaw, J. R., Bernhardt, K. A., Atkinson, E. J., Khosla, S., Kaufman, K. R. & Amin, S., Sep 1 2018, In : Gait and Posture. 65, p. 74-80 7 p.

Research output: Contribution to journalArticle

6 Scopus citations