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  • Clifford R Jr. Jack
Short survey

The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable

Knopman, D. S., Haeberlein, S. B., Carrillo, M. C., Hendrix, J. A., Kerchner, G., Margolin, R., Maruff, P., Miller, D. S., Tong, G., Tome, M. B., Murray, M. E., Nelson, P. T., Sano, M., Mattsson, N., Sultzer, D. L., Montine, T. J., Jack, C. R., Kolb, H., Petersen, R. C., Vemuri, P. & 8 others, Canniere, M. Z., Schneider, J. A., Resnick, S. M., Romano, G., van Harten, A. C., Wolk, D. A., Bain, L. J. & Siemers, E., Apr 2018, In : Alzheimer's and Dementia. 14, 4, p. 563-575 13 p.

Research output: Contribution to journalShort survey

36 Scopus citations
Review article

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Feldman, H. H., Frisoni, G. B., Hampel, H., Jagust, W. J., Johnson, K. A., Knopman, D. S., Petersen, R. C., Scheltens, P., Sperling, R. A. & Dubois, B., Aug 2 2016, In : Neurology. 87, 5, p. 539-547 9 p.

Research output: Contribution to journalReview article

385 Scopus citations

A brief history of "Alzheimer disease": Multiple meanings separated by a common name

Knopman, D. S., Petersen, R. C. & Jack, C. R., May 28 2019, In : Neurology. 92, 22, p. 1053-1059 7 p.

Research output: Contribution to journalReview article

13 Scopus citations

Alzheimer disease: New concepts on its neurobiology and the clinical role imaging will play

Jack, C. R., 2012, In : Radiology. 263, 2, p. 344-361 18 p.

Research output: Contribution to journalReview article

142 Scopus citations

Biomarker modeling of alzheimer's disease

Jack, C. R. & Holtzman, D. M., Dec 18 2013, In : Neuron. 80, 6, p. 1347-1358 12 p.

Research output: Contribution to journalReview article

434 Scopus citations

Cerebral amyloid PET imaging in Alzheimer's disease

Jack, C. R., Barrio, J. R. & Kepe, V., Nov 2013, In : Acta neuropathologica. 126, 5, p. 643-657 15 p.

Research output: Contribution to journalReview article

64 Scopus citations

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry

on Behalf of the Members of the WFSBP Task Force Working on this Topic: Peter Riederer, Carla Gallo, Dimitrios Kapogiannis, Andrea Lopez Mato, Florence Thibaut, May 19 2018, In : World Journal of Biological Psychiatry. 19, 4, p. 244-328 85 p.

Research output: Contribution to journalReview article

80 Scopus citations

Clinical validity of increased cortical uptake of amyloid ligands on PET as a biomarker for Alzheimer's disease in the context of a structured 5-phase development framework

Chiotis, K., Saint-Aubert, L., Boccardi, M., Gietl, A., Picco, A., Varrone, A., Garibotto, V., Herholz, K., Nobili, F., Nordberg, A., Frisoni, G. B., Winblad, B. & Jack, C. R., Apr 1 2017, In : Neurobiology of aging. 52, p. 214-227 14 p.

Research output: Contribution to journalReview article

34 Scopus citations

Clinical validity of medial temporal atrophy as a biomarker for Alzheimer's disease in the context of a structured 5-phase development framework

ten Kate, M., Barkhof, F., Boccardi, M., Visser, P. J., Jack, C. R., Lovblad, K. O., Frisoni, G. B. & Scheltens, P., Apr 1 2017, In : Neurobiology of aging. 52, p. 167-182.e1

Research output: Contribution to journalReview article

30 Scopus citations

Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias

Murray, M. E., Kouri, N., Lin, W. L., Jack, C. R., Dickson, D. W. & Vemuri, P., Jan 2 2014, In : Alzheimer's Research and Therapy. 6, 1, 1.

Research output: Contribution to journalReview article

61 Scopus citations

Diagnostic neuroimaging across diseases

Klöppel, S., Abdulkadir, A., Jack, C. R., Koutsouleris, N., Mourão-Miranda, J. & Vemuri, P., Jun 2012, In : NeuroImage. 61, 2, p. 457-463 7 p.

Research output: Contribution to journalReview article

181 Scopus citations

Imaging markers for Alzheimer disease: Which vs how

Frisoni, G. B., Bocchetta, M., Chételat, G., Rabinovici, G. D., De Leon, M. J., Kaye, J., Reiman, E. M., Scheltens, P., Barkhof, F., Black, S. E., Brooks, D. J., Carrillo, M. C., Fox, N. C., Herholz, K., Nordberg, A., Jack, C. R., Jagust, W. J., Johnson, K. A., Rowe, C. C., Sperling, R. A. & 5 others, Thies, W., Wahlund, L. O., Weiner, M. W., Pasqualetti, P. & DeCarli, C., Jul 30 2013, In : Neurology. 81, 5, p. 487-500 14 p.

Research output: Contribution to journalReview article

159 Scopus citations
5 Scopus citations

Imaging the Alzheimer Brain

Ashford, J. W., Salehi, A., Furst, A., Bayley, P., Frisoni, G. B., Jack, C. R., Sabri, O., Adamson, M. M., Coburn, K. L., Olichney, J., Schuff, N., Spielman, D., Edland, S. D., Black, S., Rosen, A., Kennedy, D., Weiner, M. & Perry, G., 2011, In : Journal of Alzheimer's Disease. 26, SUPPL. 3, p. 1-27 27 p.

Research output: Contribution to journalReview article

18 Scopus citations

Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014

Weiner, M. W., Veitch, D. P., Aisen, P. S., Beckett, L. A., Cairns, N. J., Cedarbaum, J., Donohue, M. C., Green, R. C., Harvey, D., Jack, C. R., Jagust, W., Morris, J. C., Petersen, R. C., Saykin, A. J., Shaw, L., Thompson, P. M., Toga, A. W. & Trojanowski, J. Q., Jul 1 2015, In : Alzheimer's and Dementia. 11, 7, p. 865-884 20 p.

Research output: Contribution to journalReview article

97 Scopus citations

Limbic-predominant age-related TDP-43 encephalopathy (LATE): Consensus working group report

Nelson, P. T., Dickson, D. W., Trojanowski, J. Q., Jack, C. R., Boyle, P. A., Arfanakis, K., Rademakers, R., Alafuzoff, I., Attems, J., Brayne, C., Coyle-Gilchrist, I. T. S., Chui, H. C., Fardo, D. W., Flanagan, M. E., Halliday, G., Hokkanen, S. R. K., Hunter, S., Jicha, G. A., Katsumata, Y., Kawas, C. H. & 15 others, Keene, C. D., Kovacs, G. G., Kukull, W. A., Levey, A. I., Makkinejad, N., Montine, T. J., Murayama, S., Murray, M. E., Nag, S., Rissman, R. A., Seeley, W. W., Sperling, R. A., White, C. L., Yu, L. & Schneider, J. A., Jun 1 2019, In : Brain. 142, 6, p. 1503-1527 25 p.

Research output: Contribution to journalReview article

Open Access
144 Scopus citations

Magnetic resonance imaging of amyloid plaques in transgenic mouse models of alzheimer's disease

Chamberlain, R., Wengenack, T. M., Poduslo, J. F., Garwood, M. & Jack, C. R., Jun 2011, In : Current Medical Imaging Reviews. 7, 1, p. 3-7 5 p.

Research output: Contribution to journalReview article

17 Scopus citations

Modifiable factors that alter the size of the hippocampus with ageing

Fotuhi, M., Do, D. & Jack, C., Apr 1 2012, In : Nature Reviews Neurology. 8, 4, p. 189-202 14 p.

Research output: Contribution to journalReview article

182 Scopus citations

Neuronal injury biomarkers and prognosis in ADNI subjects with normal cognition

Alzheimer's Disease Neuroimaging Initiative, Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 26.

Research output: Contribution to journalReview article

61 Scopus citations

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

Contributors, Apr 2018, In : Alzheimer's and Dementia. 14, 4, p. 535-562 28 p.

Research output: Contribution to journalReview article

1228 Scopus citations

On the path to 2025: Understanding the Alzheimer's disease continuum

Aisen, P. S., Cummings, J., Jack, C. R., Morris, J. C., Sperling, R., Frölich, L., Jones, R. W., Dowsett, S. A., Matthews, B. R., Raskin, J., Scheltens, P. & Dubois, B., Aug 9 2017, In : Alzheimer's Research and Therapy. 9, 1, 60.

Research output: Contribution to journalReview article

95 Scopus citations

Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria

Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer's Association on "The Preclinical State of AD"; July 23, 2015; Washington DC, USA, Mar 1 2016, In : Alzheimer's and Dementia. 12, 3, p. 292-323 32 p.

Research output: Contribution to journalReview article

509 Scopus citations

Quantitative magnetic resonance imaging phantoms: A review and the need for a system phantom

Keenan, K. E., Ainslie, M., Barker, A. J., Boss, M. A., Cecil, K. M., Charles, C., Chenevert, T. L., Clarke, L., Evelhoch, J. L., Finn, P., Gembris, D., Gunter, J. L., Hill, D. L. G., Jack, C. R., Jackson, E. F., Liu, G., Russek, S. E., Sharma, S. D., Steckner, M., Stupic, K. F. & 3 others, Trzasko, J. D., Yuan, C. & Zheng, J., Jan 2018, In : Magnetic Resonance in Medicine. 79, 1, p. 48-61 14 p.

Research output: Contribution to journalReview article

39 Scopus citations

Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials

Alzheimer's Disease Neuroimaging Initiative, Apr 1 2017, In : Alzheimer's and Dementia. 13, 4, p. e1-e85

Research output: Contribution to journalReview article

94 Scopus citations

Resting state functional MRI in Alzheimer's disease

Vemuri, P., Jones, D. T. & Jack, C. R., 2012, In : Alzheimer's Research and Therapy. 4, 1, 2.

Research output: Contribution to journalReview article

60 Scopus citations

Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

Frisoni, G. B., Boccardi, M., Barkhof, F., Blennow, K., Cappa, S., Chiotis, K., Démonet, J. F., Garibotto, V., Giannakopoulos, P., Gietl, A., Hansson, O., Herholz, K., Jack, C. R., Nobili, F., Nordberg, A., Snyder, H. M., Ten Kate, M., Varrone, A., Albanese, E., Becker, S. & 28 others, Bossuyt, P., Carrillo, M. C., Cerami, C., Dubois, B., Gallo, V., Giacobini, E., Gold, G., Hurst, S., Lönneborg, A., Lovblad, K. O., Mattsson, N., Molinuevo, J. L., Monsch, A. U., Mosimann, U., Padovani, A., Picco, A., Porteri, C., Ratib, O., Saint-Aubert, L., Scerri, C., Scheltens, P., Schott, J. M., Sonni, I., Teipel, S., Vineis, P., Visser, P. J., Yasui, Y. & Winblad, B., Aug 2017, In : The Lancet Neurology. 16, 8, p. 661-676 16 p.

Research output: Contribution to journalReview article

186 Scopus citations

Suspected non-Alzheimer disease pathophysiology-concept and controversy

Jack, C. R., Knopman, D. S., Chételat, G., Dickson, D., Fagan, A. M., Frisoni, G. B., Jagust, W., Mormino, E. C., Petersen, R. C., Sperling, R. A., Van Der Flier, W. M., Villemagne, V. L., Visser, P. J. & Vos, S. J. B., Feb 1 2016, In : Nature Reviews Neurology. 12, 2, p. 117-124 8 p.

Research output: Contribution to journalReview article

141 Scopus citations

The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

Weiner, M. W., Veitch, D. P., Aisen, P. S., Beckett, L. A., Cairns, N. J., Green, R. C., Harvey, D., Jack, C. R., Jagust, W., Liu, E., Morris, J. C., Petersen, R. C., Saykin, A. J., Schmidt, M. E., Shaw, L., Shen, L., Siuciak, J. A., Soares, H., Toga, A. W. & Trojanowski, J. Q., Sep 2013, In : Alzheimer's and Dementia. 9, 5, p. e111-e194

Research output: Contribution to journalReview article

253 Scopus citations

The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement

Alzheimer's Disease Neuroimaging Initiative, May 2017, In : Alzheimer's and Dementia. 13, 5, p. 561-571 11 p.

Research output: Contribution to journalReview article

51 Scopus citations

The biomarker-based diagnosis of Alzheimer's disease. 2—lessons from oncology

Geneva Task Force for the Roadmap of Alzheimer's Biomarkers, Apr 1 2017, In : Neurobiology of aging. 52, p. 141-152 12 p.

Research output: Contribution to journalReview article

22 Scopus citations

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative

Alzheimer's Disease Neuroimaging Initiative, Jan 2019, In : Alzheimer's and Dementia. 15, 1, p. 106-152 47 p.

Research output: Contribution to journalReview article

52 Scopus citations
Letter

[18F]AV-1451 tau-PET uptake does correlate with quantitatively measured 4R-tau burden in autopsy-confirmed corticobasal degeneration

Josephs, K. A., Whitwell, J. L., Tacik, P., Duffy, J. R., Senjem, M. L., Tosakulwong, N., Jack, C. R., Lowe, V., Dickson, D. W. & Murray, M. E., Dec 1 2016, In : Acta neuropathologica. 132, 6, p. 931-933 3 p.

Research output: Contribution to journalLetter

72 Scopus citations

Alzheimer Disease, Biomarkers, and Clinical Symptoms-Quo Vadis?-Reply

Jack, C. R., Jan 1 2020, (Accepted/In press) In : JAMA neurology.

Research output: Contribution to journalLetter

1 Scopus citations
11 Scopus citations

PART, a distinct tauopathy, different from classical sporadic Alzheimer disease

Jellinger, K. A., Alafuzoff, I., Attems, J., Beach, T. G., Cairns, N. J., Crary, J. F., Dickson, D. W., Hof, P. R., Hyman, B. T., Jack, C. R., Jicha, G. A., Knopman, D. S., Kovacs, G. G., Mackenzie, I. R., Masliah, E., Montine, T. J., Nelson, P. T., Schmitt, F., Schneider, J. A., Serrano-Pozo, A. & 6 others, Thal, D. R., Toledo, J. B., Trojanowski, J. Q., Troncoso, J. C., Vonsattel, J. P. & Wisniewski, T., May 1 2015, In : Acta neuropathologica. 129, 5, p. 757-762 6 p.

Research output: Contribution to journalLetter

86 Scopus citations

PART and SNAP

Jack, C. R., Nov 14 2014, In : Acta neuropathologica. 128, 6, p. 773-776 4 p.

Research output: Contribution to journalLetter

56 Scopus citations

Preclinical Alzheimer's disease: a valid concept

Jack, C. R., Jan 2020, In : The Lancet Neurology. 19, 1, 1 p.

Research output: Contribution to journalLetter

Open Access
1 Scopus citations

Reply: LATE to the PART-y

Nelson, P. T., Dickson, D. W., Trojanowski, J. Q., Jack, C. R., Boyle, P. A., Arfanakis, K., Rademakers, R., Alafuzoff, I., Attems, J., Brayne, C., Coyle-Gilchrist, I. T. S., Fardo, D. W., Flanagan, M. E., Halliday, G., Hunter, S., Jicha, G. A., Katsumata, Y., Kawas, C. H., Dirk Keene, C., Kovacs, G. G. & 10 others, Kukull, W. A., Levey, A. I., Makkinejad, N., Montine, T. J., Murray, M. E., Nag, S., Seeley, W. W., Sperling, R. A., White, C. L. & Schneider, J. A., Sep 1 2019, In : Brain. 142, 9, p. 1-3 3 p.

Research output: Contribution to journalLetter

Reply: Multiple imputation models should incorporate the outcome in the model of interest

Weigand, S. D. & Jack, C. R., Nov 2011, In : Brain. 134, 11, p. e190

Research output: Contribution to journalLetter

1 Scopus citations
Foreword/postscript

Section 2: Structural imaging

Bayley, P. J., Frisoni, G. B. & Jack, C. R., Dec 1 2011, Handbook of Imaging the Alzheimer Brain. Wesson Ashford, J., Rosen, A., Adamson, M., Bayley, P., Furst, A., Sabri, O., Black, S. E. & Weiner, M. (eds.). p. 45-46 2 p. (Advances in Alzheimer's Disease; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Editorial

Alzheimer's disease biomarker development: a call to funding bodies

Frisoni, G. B., Jack, C. R. J. & Winblad, B., Apr 1 2017, In : Neurobiology of Aging. 52, p. 117-118 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations
3 Scopus citations

Aβ imaging: Feasible, pertinent, and vital to progress in Alzheimer's disease

Villemagne, V. L., Klunk, W. E., Mathis, C. A., Rowe, C. C., Brooks, D. J., Hyman, B. T., Ikonomovic, M. D., Ishii, K., Jack, C. R., Jagust, W. J., Johnson, K. A., Koeppe, R. A., Lowe, V. J., Masters, C. L., Montine, T. J., Morris, J. C., Nordberg, A., Petersen, R. C., Reiman, E. M., Selkoe, D. J. & 4 others, Sperling, R. A., Van Laere, K., Weiner, M. W. & Drzezga, A., Feb 2012, In : European Journal of Nuclear Medicine and Molecular Imaging. 39, 2, p. 209-219 11 p.

Research output: Contribution to journalEditorial

36 Scopus citations

Brain atrophy on magnetic resonance imaging as a biomarker of neurodegeneration

Jack, C. R. J., Oct 1 2016, In : JAMA Neurology. 73, 10, p. 1179-1182 4 p.

Research output: Contribution to journalEditorial

4 Scopus citations

Cardiorespiratory Fitness and Brain Volumes

Petersen, R. C., Joyner, M. J. & Jack, C. R., Jan 2020, In : Mayo Clinic proceedings. 95, 1, p. 6-8 3 p.

Research output: Contribution to journalEditorial

Open Access
1 Scopus citations

Dementia is not synonymous with Alzheimer’s disease

Jack, C., Holtzman, D. & Sperling, R., Dec 11 2019, In : Science translational medicine. 11, 522, eaav0511.

Research output: Contribution to journalEditorial

3 Scopus citations

Harmonization of magnetic resonance-based manual hippocampal segmentation: A mandatory step for wide clinical use

Frisoni, G. B. & Jack, C. R., Mar 2011, In : Alzheimer's and Dementia. 7, 2, p. 171-174 4 p.

Research output: Contribution to journalEditorial

76 Scopus citations

Massachusetts Alzheimer's Disease Research Center: Progress and challenges

Hyman, B. T., Growdon, J. H., Albers, M. W., Buckner, R. L., Chhatwal, J., Gomez-Isla, M. T., Haass, C., Hudry, E., Jack, C. R., Johnson, K. A., Khachaturian, Z. S., Kim, D. Y., Martin, J. B., Nitsch, R. M., Rosen, B. R., Selkoe, D. J., Sperling, R. A., St George-Hyslop, P., Tanzi, R. E., Yap, L. & 3 others, Young, A. B., Phelps, C. H. & McCaffrey, P. G., Oct 2015, In : Alzheimer's and Dementia. 11, 10, p. 1241-1245 5 p.

Research output: Contribution to journalEditorial

4 Scopus citations

“Alzheimer's disease” is neither “Alzheimer's clinical syndrome” nor “dementia”

Jagust, W., Jack, C. R., Bennett, D. A., Blennow, K., Haeberlein, S. B., Holtzman, D. M., Jessen, F., Karlawish, J., Liu, E., Molinuevo, J. L., Montine, T., Phelps, C., Rankin, K. P., Rowe, C. C., Scheltens, P., Siemers, E. & Sperling, R., Jan 2019, In : Alzheimer's and Dementia. 15, 1, p. 153-157 5 p.

Research output: Contribution to journalEditorial

10 Scopus citations