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  • Clifford R Jr. Jack
Article

Regional differences in MRI detection of amyloid plaques in AD transgenic mouse brain

Wengenack, T. M., Reyes, D. A., Curran, G. L., Borowski, B. J., Lin, J., Preboske, G. M., Holasek, S. S., Gilles, E. J., Chamberlain, R., Marjanska, M., Jack, C. R., Garwood, M. & Poduslo, J. F., Jan 1 2011, In : NeuroImage. 54, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Regional Distribution, Asymmetry, and Clinical Correlates of Tau Uptake on [18F]AV-1451 PET in Atypical Alzheimer's Disease

Tetzloff, K. A., Graff-Radford, J., Martin, P. R., Tosakulwong, N., Machulda, M. M., Duffy, J. R., Clark, H. M., Senjem, M. L., Schwarz, C. G., Spychalla, A. J., Drubach, D. A., Jack, C. R., Lowe, V. J., Josephs, K. A. & Whitwell, J. L., 2018, In : Journal of Alzheimer's Disease. 62, 4, p. 1713-1724 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Regional multimodal relationships between tau, hypometabolism, atrophy, and fractional anisotropy in atypical Alzheimer's disease

Sintini, I., Schwarz, C. G., Martin, P. R., Graff-Radford, J., Machulda, M. M., Senjem, M. L., Reid, R. I., Spychalla, A. J., Drubach, D. A., Lowe, V. J., Jack, C. R., Josephs, K. A. & Whitwell, J. L., Apr 1 2019, In : Human Brain Mapping. 40, 5, p. 1618-1631 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Regional proton magnetic resonance spectroscopy patterns in dementia with Lewy bodies

Graff-Radford, J., Boeve, B. F., Murray, M. E., Ferman, T. J., Tosakulwong, N., Lesnick, T. G., Maroney-Smith, M., Senjem, M. L., Gunter, J., Smith, G. E., Knopman, D. S., Jack, C. R., Dickson, D. W., Petersen, R. C. & Kantarci, K., Jun 2014, In : Neurobiology of aging. 35, 6, p. 1483-1490 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Regional T1 relaxation time constants in Ex vivo human brain: Longitudinal effects of formalin exposure

Raman, M. R., Shu, Y., Lesnick, T. G., Jack, C. R. & Kantarci, K., Feb 1 2017, In : Magnetic Resonance in Medicine. 77, 2, p. 774-778 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease

Benzinger, T. L. S., Blazey, T., Jack, C. R., Koeppe, R. A., Su, Y., Xiong, C., Raichle, M. E., Snyder, A. Z., Ances, B. M., Bateman, R. J., Cairns, N. J., Fagan, A. M., Goate, A., Marcus, D. S., Aisen, P. S., Christensen, J. J., Ercole, L., Hornbeck, R. C., Farrar, A. M., Aldea, P. & 30 others, Jasielec, M. S., Owen, C. J., Xie, X., Mayeux, R., Brickman, A., McDade, E., Klunk, W., Mathis, C. A., Ringman, J., Thompson, P. M., Ghetti, B., Saykin, A. J., Sperling, R. A., Johnson, K. A., Salloway, S., Correia, S., Schofield, P. R., Masters, C. L., Rowe, C., Villemagne, V. L., Martins, R., Ourselin, S., Rossor, M. N., Fox, N. C., Cash, D. M., Weiner, M. W., Holtzman, D. M., Buckles, V. D., Moulder, K. & Morris, J. C., Nov 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 47, p. E4502-E4509

Research output: Contribution to journalArticle

184 Scopus citations

Regional β-amyloid burden does not correlate with cognitive or language deficits in Alzheimer's disease presenting as aphasia

Jung, Y., Whitwell, J. L., Duffy, J. R., Strand, E. A., Machulda, M. M., Senjem, M. L., Jack, C. R., Lowe, V. J. & Josephs, K. A., Feb 1 2016, In : European Journal of Neurology. 23, 2, p. 313-319 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Relationship between hippocampal atrophy and neuropathology markers: A 7T MRI validation study of the EADC-ADNI harmonized hippocampal segmentation protocol

Apostolova, L. G., Zarow, C., Biado, K., Hurtz, S., Boccardi, M., Somme, J., Honarpisheh, H., Blanken, A. E., Brook, J., Tung, S., Kraft, E., Lo, D., Ng, D., Alger, J. R., Vinters, H. V., Bocchetta, M., Duvernoy, H., Jack, C. R., Frisoni, G. B., Bartzokis, G. & 10 others, Csernansky, J. G., De Leon, M. J., Detoledo-Morrell, L., Killiany, R. J., Lehericy, S., Malykhin, N., Pantel, J., Pruessner, J. C., Soininen, H. & Watson, C., 2015, In : Alzheimer's and Dementia. 11, 2, p. 139-150 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Rich club analysis in the Alzheimer's disease connectome reveals a relatively undisturbed structural core network

The Alzheimer's Disease Neuroimaging Initiative, 2015, In : Human Brain Mapping. 36, 8, p. 3087-3103 17 p.

Research output: Contribution to journalArticle

69 Scopus citations

Risk factor profile for chronic kidney disease is similar to risk factor profile for small artery disease

Turner, S. T., Rule, A. D., Schwartz, G. L., Kullo, I. J., Mosley, T. H., Jack, C. R., Kardia, S. L. R., Boerwinkle, E. & Bailey, K. R., Sep 2011, In : Journal of hypertension. 29, 9, p. 1796-1801 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Robustness of automated hippocampal volumetry across magnetic resonance field strengths and repeat images

Wolz, R., Schwarz, A. J., Yu, P., Cole, P. E., Rueckert, D., Jack, C. R., Raunig, D. & Hill, D., Jul 2014, In : Alzheimer's and Dementia. 10, 4, p. 430-438.e2

Research output: Contribution to journalArticle

21 Scopus citations

Role of β-Amyloidosis and Neurodegeneration in Subsequent Imaging Changes in Mild Cognitive Impairment

Knopman, D. S., Jack, C. R. J., Lundt, E. S., Wiste, H. J., Weigand, S. D., Vemuri, P. D., Lowe, V., Kantarci, K. M., Gunter, J. L., Senjem, M. L., Mielke, M. M., Machulda, M. M., Roberts, R. O., Boeve, B. F., Jones, D. T. & Petersen, R. C., Dec 1 2015, In : JAMA Neurology. 72, 12, p. 1475-1483 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Sample size calculations for clinical trials targeting tauopathies: a new potential disease target

Whitwell, J. L., Duffy, J. R., Strand, E. A., Machulda, M. M., Tosakulwong, N., Weigand, S. D., Senjem, M. L., Spychalla, A. J., Gunter, J. L., Petersen, R. C., Jack, C. R. & Josephs, K. A., Sep 22 2015, In : Journal of Neurology. 262, 9, p. 2064-2072 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Seemingly unrelated regression empowers detection of network failure in dementia

Alzheimer's Disease Neuroimaging Initiative, Jan 1 2015, In : Neurobiology of aging. 36, S1, p. S103-S112

Research output: Contribution to journalArticle

6 Scopus citations

Selective worsening of brain injury biomarker abnormalities in cognitively normal elderly persons with β-amyloidosis

Knopman, D. S., Jack, C. R., Wiste, H. J., Weigand, S. D., Vemuri, P., Lowe, V. J., Kantarci, K., Gunter, J. L., Senjem, M. L., Mielke, M. M., Roberts, R. O., Boeve, B. F. & Petersen, R. C., Aug 2013, In : JAMA neurology. 70, 8, p. 1030-1038 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Sensitivity–Specificity of Tau and Amyloid β Positron Emission Tomography in Frontotemporal Lobar Degeneration

Ghirelli, A., Tosakulwong, N., Weigand, S. D., Clark, H. M., Ali, F., Botha, H., Duffy, J. R., Utianski, R., Buciuc, M., Murray, M. E., Labuzan, S. A., Spychalla, A. J., Pham, N. T. T., Schwarz, C. G., Senjem, M. L., Machulda, M. M., Baker, M., Rademakers, R., Filippi, M., Jack, C. R. & 5 others, Lowe, V. J., Parisi, J. E., Dickson, D. W., Josephs, K. A. & Whitwell, J. L., 2020, (Accepted/In press) In : Annals of neurology.

Research output: Contribution to journalArticle

Serum Adiponectin Levels, Neuroimaging, and Cognition in the Mayo Clinic Study of Aging

Wennberg, A. M. V., Gustafson, D., Hagen, C. E., Roberts, R. O., Knopman, D., Jack, C., Petersen, R. C. & Mielke, M. M., 2016, In : Journal of Alzheimer's Disease. 53, 2, p. 573-581 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Serum cholesterol and variant in cholesterol-related gene CETP predict white matter microstructure

Alzheimer's Disease Neuroimaging Initiative (ADNI), Nov 1 2014, In : Neurobiology of aging. 35, 11, p. 2504-2513 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

Dominantly Inherited Alzheimer Network, Feb 1 2019, In : Nature Medicine. 25, 2, p. 277-283 7 p.

Research output: Contribution to journalArticle

134 Scopus citations

Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease

for the Dominantly Inherited Alzheimer Network, Aug 2020, In : Neurobiology of Disease. 142, 104960.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Severity dependent distribution of impairments in PSP and CBS: Interactive visualizations

The AL-108-231 Study Group, The PROPSPERA investigators, 4RNTI-1authors & Tau Restoration on PSP (TAUROS) Investigators, Mar 2019, In : Parkinsonism and Related Disorders. 60, p. 138-145 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Sex differences in cerebrovascular pathologies on FLAIR in cognitively unimpaired elderly

Fatemi, F., Kantarci, K., Graff-Radford, J., Preboske, G. M., Weigand, S. D., Przybelski, S. A., Knopman, D. S., MacHulda, M. M., Roberts, R. O., Mielke, M. M., Petersen, R. C., Jack, C. R. & Vemuri, P., Feb 6 2018, In : Neurology. 90, 6, p. e466-e473

Research output: Contribution to journalArticle

5 Scopus citations

Sex-specific genetic predictors of Alzheimer’s disease biomarkers

Alzheimer’s Disease Neuroimaging Initiative (ADNI) & The Alzheimer Disease Genetics Consortium (Adgc), Dec 1 2018, In : Acta neuropathologica. 136, 6, p. 857-872 16 p.

Research output: Contribution to journalArticle

22 Scopus citations

Shapes of the trajectories of 5 major biomarkers of Alzheimer disease

Jack, C. R., Vemuri, P., Wiste, H. J., Weigand, S. D., Lesnick, T. G., Lowe, V., Kantarci, K., Bernstein, M. A., Senjem, M. L., Gunter, J. L., Boeve, B. F., Trojanowski, J. Q., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C. & Knopman, D. S., Jul 2012, In : Archives of neurology. 69, 7, p. 856-867 12 p.

Research output: Contribution to journalArticle

90 Scopus citations

Short-term clinical outcomes for stages of NIA-AA preclinical Alzheimer disease

Knopman, D. S., Jack, C. R., Wiste, H. J., Weigand, S. D., Vemuri, P., Lowe, V., Kantarci, K., Gunter, J. L., Senjem, M. L., Ivnik, R. J., Roberts, R. O., Boeve, B. F. & Petersen, R. C., May 15 2012, In : Neurology. 78, 20, p. 1576-1582 7 p.

Research output: Contribution to journalArticle

187 Scopus citations

Sleep apnea, sleep duration and brain mri markers of cerebral vascular disease and Alzheimer's disease: The atherosclerosis risk in communities study (ARIC)

Lutsey, P. L., Norby, F. L., Gottesman, R. F., Mosley, T., MacLehose, R. F., Punjabi, N. M., Shahar, E., Jack, C. R. & Alonso, A., Jul 2016, In : PloS one. 11, 7, e0158758.

Research output: Contribution to journalArticle

17 Scopus citations

Smoking and white matter hyperintensity progression: The ARIC-MRI Study

Power, M. C., Deal, J. A., Sharrett, A. R., Jack, C. R., Knopman, D., Mosley, T. H. & Gottesman, R. F., Feb 24 2015, In : Neurology. 84, 8, p. 841-848 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study

Gordon, B. A., Blazey, T. M., Su, Y., Hari-Raj, A., Dincer, A., Flores, S., Christensen, J., McDade, E., Wang, G., Xiong, C., Cairns, N. J., Hassenstab, J., Marcus, D. S., Fagan, A. M., Jack, C. R., Hornbeck, R. C., Paumier, K. L., Ances, B. M., Berman, S. B., Brickman, A. M. & 20 others, Cash, D. M., Chhatwal, J. P., Correia, S., Förster, S., Fox, N. C., Graff-Radford, N. R., la Fougère, C., Levin, J., Masters, C. L., Rossor, M. N., Salloway, S., Saykin, A. J., Schofield, P. R., Thompson, P. M., Weiner, M. M., Holtzman, D. M., Raichle, M. E., Morris, J. C., Bateman, R. J. & Benzinger, T. L. S., Mar 2018, In : The Lancet Neurology. 17, 3, p. 241-250 10 p.

Research output: Contribution to journalArticle

81 Scopus citations

Staging TDP-43 pathology in Alzheimer's disease

Josephs, K. A., Murray, M. E., Whitwell, J. L., Parisi, J. E., Petrucelli, L., Jack, C. R., Petersen, R. C. & Dickson, D. W., Mar 2014, In : Acta neuropathologica. 127, 3, p. 441-450 10 p.

Research output: Contribution to journalArticle

161 Scopus citations

Statins and Brain Health: Alzheimer's Disease and Cerebrovascular Disease Biomarkers in Older Adults

Ramanan, V. K., Przybelski, S. A., Graff-Radford, J., Castillo, A. M., Lowe, V. J., Mielke, M. M., Roberts, R. O., Reid, R. I., Knopman, D. S., Jack, C. R., Petersen, R. C. & Vemuri, P., 2018, In : Journal of Alzheimer's Disease. 65, 4, p. 1345-1352 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Steroid-responsive encephalopathy subsequently associated with Alzheimer's disease pathology: A case series

Mateen, F. J., Josephs, K. A., Parisi, J. E., Drubach, D. A., Caselli, R. J., Kantarci, K., Jack, C. & Boeve, B. F., Feb 2012, In : Neurocase. 18, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
16 Scopus citations

Survey of protocols for the manual segmentation of the hippocampus: Preparatory steps towards a joint EADC-ADNI harmonized protocol

Boccardi, M., Ganzola, R., Bocchetta, M., Pievani, M., Redolfi, A., Bartzokis, G., Camicioli, R., Csernansky, J. G., De Leon, M. J., Detoledo-Morrell, L., Killiany, R. J., Lehéricy, S., Pantel, J., Pruessner, J. C., Soininen, H., Watson, C., Duchesne, S., Jack, C. R. & Frisoni, G. B., 2011, In : Journal of Alzheimer's Disease. 26, SUPPL. 3, p. 61-75 15 p.

Research output: Contribution to journalArticle

104 Scopus citations

Syndromes dominated by apraxia of speech show distinct characteristics from agrammatic PPA

Josephs, K. A., Duffy, J. R., Strand, E. A., Machulda, M. M., Senjem, M. L., Lowe, V. J., Jack, C. R. & Whitwell, J. L., Jul 23 2013, In : Neurology. 81, 4, p. 337-345 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease

Alzheimer's Disease Neuroimaging Initiative (ADNI), Dec 2017, In : Neurobiology of aging. 60, p. 92-103 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Targeting vascular amyloid in arterioles of alzheimer disease transgenic mice with amyloid β protein antibody-coated nanoparticles

Poduslo, J. F., Hultman, K. L., Curran, G. L., Preboske, G. M., Chamberlain, R., Marjańska, M., Garwood, M., Jack, C. R. & Wengenack, T. M., Aug 2011, In : Journal of Neuropathology and Experimental Neurology. 70, 8, p. 653-661 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Tau, amyloid, and cascading network failure across the Alzheimer's disease spectrum

Jones, D. T., Graff-Radford, J., Lowe, V. J., Wiste, H. J., Gunter, J. L., Senjem, M. L., Botha, H., Kantarci, K., Boeve, B. F., Knopman, D. S., Petersen, R. C. & Jack, C. R., Dec 2017, In : Cortex. 97, p. 143-159 17 p.

Research output: Contribution to journalArticle

44 Scopus citations
57 Scopus citations

Tau-negative amnestic dementia masquerading as Alzheimer disease dementia

Botha, H., Mantyh, W. G., Graff-Radford, J., Machulda, M. M., Przybelski, S. A., Wiste, H. J., Senjem, M. L., Parisi, J. E., Petersen, R. C., Murray, M. E., Boeve, B. F., Lowe, V., Knopman, D. S., Jack, C. R. J. & Jones, D. T., Mar 13 2018, In : Neurology. 90, 11, p. e940-e946

Research output: Contribution to journalArticle

8 Scopus citations

Tau-PET imaging with [18F]AV-1451 in primary progressive apraxia of speech

Utianski, R. L., Whitwell, J. L., Schwarz, C. G., Senjem, M. L., Tosakulwong, N., Duffy, J. R., Clark, H. M., Machulda, M. M., Petersen, R. C., Jack, C. R., Lowe, V. J. & Josephs, K. A., Feb 2018, In : Cortex. 99, p. 358-374 17 p.

Research output: Contribution to journalArticle

20 Scopus citations

Tau PET in autosomal dominant Alzheimer's disease: Relationship with cognition, dementia and other biomarkers

Gordon, B. A., Blazey, T. M., Christensen, J., Dincer, A., Flores, S., Keefe, S., Chen, C., Su, Y., McDade, E. M., Wang, G., Li, Y., Hassenstab, J., Aschenbrenner, A., Hornbeck, R., Jack, C. R., Ances, B. M., Berman, S. B., Brosch, J. R., Galasko, D., Gauthier, S. & 14 others, Lah, J. J., Masellis, M., Van Dyck, C. H., Mintun, M. A., Klein, G., Ristic, S., Cairns, N. J., Marcus, D. S., Xiong, C., Holtzman, D. M., Raichle, M. E., Morris, J. C., Bateman, R. J. & Benzinger, T. L. S., 2019, In : Brain. 142, 4, p. 1063-1076 14 p.

Research output: Contribution to journalArticle

20 Scopus citations
41 Scopus citations

Tau-positron emission tomography correlates with neuropathology findings

Lowe, V. J., Lundt, E. S., Albertson, S. M., Min, H. K., Fang, P., Przybelski, S. A., Senjem, M. L., Schwarz, C. G., Kantarci, K., Boeve, B., Jones, D. T., Reichard, R. R., Tranovich, J. F., Hanna Al-Shaikh, F. S., Knopman, D. S., Jack, C. R., Dickson, D. W., Petersen, R. C. & Murray, M. E., Mar 1 2020, In : Alzheimer's and Dementia. 16, 3, p. 561-571 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
8 Scopus citations
16 Scopus citations

TDP-43 is a key player in the clinical features associated with Alzheimer's disease

Josephs, K. A., Whitwell, J. L., Weigand, S. D., Murray, M. E., Tosakulwong, N., Liesinger, A. M., Petrucelli, L., Senjem, M. L., Knopman, D. S., Boeve, B. F., Ivnik, R. J., Smith, G. E., Jack, C. R., Parisi, J. E., Petersen, R. C. & Dickson, D. W., Jun 2014, In : Acta neuropathologica. 127, 6, p. 811-824 14 p.

Research output: Contribution to journalArticle

166 Scopus citations

Temporoparietal atrophy: A marker of AD pathology independent of clinical diagnosis

Whitwell, J. L., Jack, C. R., Przybelski, S. A., Parisi, J. E., Senjem, M. L., Boeve, B. F., Knopman, D. S., Petersen, R. C., Dickson, D. W. & Josephs, K. A., Sep 2011, In : Neurobiology of aging. 32, 9, p. 1531-1541 11 p.

Research output: Contribution to journalArticle

66 Scopus citations

Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer's disease

The PREVENT-AD Research Group, Oct 13 2015, In : Scientific Data. 2, 150043.

Research output: Contribution to journalArticle

19 Scopus citations

The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation

Wang, Q., Guo, L., Thompson, P. M., Jack, C. R., Dodge, H., Zhan, L. & Zhou, J., 2018, In : Journal of Alzheimer's Disease. 64, 1, p. 149-169 21 p.

Research output: Contribution to journalArticle

4 Scopus citations

The Alzheimer's disease neuroimaging initiative: A review of papers published since its inception

Weiner, M. W., Veitch, D. P., Aisen, P. S., Beckett, L. A., Cairns, N. J., Green, R. C., Harvey, D., Jack, C. R., Jagust, W., Liu, E., Morris, J. C., Petersen, R. C., Saykin, A. J., Schmidt, M. E., Shaw, L., Siuciak, J. A., Soares, H., Toga, A. W. & Trojanowski, J. Q., Feb 2012, In : Alzheimer's and Dementia. 8, 1 SUPPL., p. S1-S68

Research output: Contribution to journalArticle

370 Scopus citations