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  • Clifford R Jr. Jack
2011

Accurate measurement of brain changes in longitudinal MRI scans using tensor-based morphometry

Hua, X., Gutman, B., Boyle, C. P., Rajagopalan, P., Leow, A. D., Yanovsky, I., Kumar, A. R., Toga, A. W., Jack, C. R., Schuff, N., Alexander, G. E., Chen, K., Reiman, E. M., Weiner, M. W. & Thompson, P. M., Jul 1 2011, In : NeuroImage. 57, 1, p. 5-14 10 p.

Research output: Contribution to journalComment/debate

65 Scopus citations

Age-related changes in the default mode network are more advanced in Alzheimer disease

Jones, D. T., MacHulda, M. M., Vemuri, P., McDade, E. M., Zeng, G., Senjem, M. L., Gunter, J. L., Przybelski, S. A., Avula, R. T., Knopman, D. S., Boeve, B. F., Petersen, R. C. & Jack, C. R., Oct 18 2011, In : Neurology. 77, 16, p. 1524-1531 8 p.

Research output: Contribution to journalArticle

202 Scopus citations

Alliance for Aging Research AD Biomarkers Work Group: Structural MRI

Jack, C. R., Dec 2011, In : Neurobiology of aging. 32, SUPPL. 1, p. S48-S57

Research output: Contribution to journalArticle

36 Scopus citations

Altered functional connectivity in asymptomatic MAPT subjects A comparison to bvFTD

Whitwell, J. L., Josephs, K. A., Avula, R., Tosakulwong, N., Weigand, S. D., Senjem, M. L., Vemuri, P., Jones, D. T., Gunter, J. L., Baker, M., Wszolek, Z. K., Knopman, D. S., Rademakers, R., Petersen, R. C., Boeve, B. F. & Jack, C. R., Aug 30 2011, In : Neurology. 77, 9, p. 866-874 9 p.

Research output: Contribution to journalArticle

88 Scopus citations

Alzheimer’s disease versus dementia with Lewy bodies: MR spectroscopy characteristics

Kantarci, K. M. & Jack, C. R. J., Jan 1 2011, Clinical MR Neuroimaging: Physiological and Functional Techniques, Second Edition. Cambridge University Press, p. 628 1 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer's Association Research Roundtable Workgroup

Sperling, R. A., Jack, C. R., Black, S. E., Frosch, M. P., Greenberg, S. M., Hyman, B. T., Scheltens, P., Carrillo, M. C., Thies, W., Bednar, M. M., Black, R. S., Brashear, H. R., Grundman, M., Siemers, E. R., Feldman, H. H. & Schindler, R. J., Jul 2011, In : Alzheimer's and Dementia. 7, 4, p. 367-385 19 p.

Research output: Contribution to journalArticle

284 Scopus citations

Antemortem differential diagnosis of dementia pathology using structural MRI: Differential-STAND

Vemuri, P., Simon, G., Kantarci, K., Whitwell, J. L., Senjem, M. L., Przybelski, S. A., Gunter, J. L., Josephs, K. A., Knopman, D. S., Boeve, B. F., Ferman, T. J., Dickson, D. W., Parisi, J. E., Petersen, R. C. & Jack, C. R., Mar 15 2011, In : NeuroImage. 55, 2, p. 522-531 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Boosting power to detect genetic associations in imaging using multi-locus, genome-wide scans and ridge regression

Kohannim, O., Hibar, D. P., Stein, J. L., Jahanshad, N., Jack, C. R., Weiner, M. W., Toga, A. W. & Thompson, P. M., Nov 2 2011, 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11. p. 1855-1859 5 p. 5872769. (Proceedings - International Symposium on Biomedical Imaging).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

19 Scopus citations

Characterizing Alzheimer's disease using a hypometabolic convergence index

Chen, K., Ayutyanont, N., Langbaum, J. B. S., Fleisher, A. S., Reschke, C., Lee, W., Liu, X., Bandy, D., Alexander, G. E., Thompson, P. M., Shaw, L., Trojanowski, J. Q., Jack, C. R., Landau, S. M., Foster, N. L., Harvey, D. J., Weiner, M. W., Koeppe, R. A., Jagust, W. J. & Reiman, E. M., May 1 2011, In : NeuroImage. 56, 1, p. 52-60 9 p.

Research output: Contribution to journalArticle

111 Scopus citations

Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease

Tariot, P. N., Schneider, L. S., Cummings, J., Thomas, R. G., Raman, R., Jakimovich, L. J., Loy, R., Bartocci, B., Fleisher, A., Ismail, M. S., Porsteinsson, A., Weiner, M., Jack, C. R., Thal, L. & Aisen, P. S., Aug 2011, In : Archives of General Psychiatry. 68, 8, p. 853-861 9 p.

Research output: Contribution to journalArticle

112 Scopus citations

Chronic divalproex sodium use and brain atrophy in Alzheimer disease

Fleisher, A. S., Truran, D., Mai, J. T., Langbaum, J. B. S., Aisen, P. S., Cummings, J. L., Jack, C. R., Weiner, M. W., Thomas, R. G., Schneider, L. S. & Tariot, P. N., Sep 27 2011, In : Neurology. 77, 13, p. 1263-1271 9 p.

Research output: Contribution to journalArticle

79 Scopus citations

Clinical characterization of a kindred with a novel 12-octapeptide repeat insertion in the prion protein gene

Kumar, N., Boeve, B. F., Boot, B. P., Orr, C. F., Duffy, J., Woodruff, B. K., Nair, A. K., Ellison, J., Kuntz, K., Kantarci, K., Jack, C. R., Westmoreland, B. F., Fields, J. A., Baker, M., Rademakers, R., Parisi, J. E. & Dickson, D. W., Sep 2011, In : Archives of neurology. 68, 9, p. 1165-1170 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Clinical correlates of white matter tract degeneration in progressive supranuclear palsy

Whitwell, J. L., Master, A. V., Avula, R., Kantarci, K., Eggers, S. D., Edmonson, H. A., Jack, C. R. & Josephs, K. A., Jun 2011, In : Archives of neurology. 68, 6, p. 753-760 8 p.

Research output: Contribution to journalArticle

73 Scopus citations

Cognitive reserve and Alzheimer's disease biomarkers are independent determinants of cognition

Vemuri, P., Weigand, S. D., Przybelski, S. A., Knopman, D. S., Smith, G. E., Trojanowski, J. Q., Shaw, L. M., Decarli, C. S., Carmichael, O., Bernstein, M. A., Aisen, P. S., Weiner, M., Petersen, R. C. & Jack, C. R., May 2011, In : Brain. 134, 5, p. 1479-1492 14 p.

Research output: Contribution to journalArticle

89 Scopus citations

Decreased brain stiffness in Alzheimer's disease determined by magnetic resonance elastography

Murphy, M. C., Huston, J., Jack, C. R., Glaser, K. J., Manduca, A., Felmlee, J. P. & Ehman, R. L., Sep 2011, In : Journal of Magnetic Resonance Imaging. 34, 3, p. 494-498 5 p.

Research output: Contribution to journalArticle

161 Scopus citations

Default mode network disruption secondary to a lesion in the anterior thalamus

Jones, D. T., Mateen, F. J., Lucchinetti, C. F., Jack, C. R. & Welker, K. M., Feb 1 2011, In : Archives of neurology. 68, 2, p. 242-247 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Diffusion tensor imaging and cognitive function in older adults with no dementia

Kantarci, K., Senjem, M. L., Avula, R., Zhang, B., Samikoglu, A. R., Weigand, S. D., Przybelski, S. A., Edmonson, H. A., Vemuri, P., Knopman, D. S., Boeve, B. F., Ivnik, R. J., Smith, G. E., Petersen, R. C. & Jack, C. R., Jul 5 2011, In : Neurology. 77, 1, p. 26-34 9 p.

Research output: Contribution to journalArticle

101 Scopus citations

Discovery and replication of dopamine-related gene effects on caudate volume in young and elderly populations (N1198) using genome-wide search

Stein, J. L., Hibar, D. P., Madsen, S. K., Khamis, M., McMahon, K. L., De Zubicaray, G. I., Hansell, N. K., Montgomery, G. W., Martin, N. G., Wright, M. J., Saykin, A. J., Jack, C. R., Weiner, M. W., Toga, A. W. & Thompson, P. M., Sep 2011, In : Molecular Psychiatry. 16, 9, p. 927-937 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Disrupted thalamocortical connectivity in PSP: A resting-state fMRI, DTI, and VBM study

Whitwell, J. L., Avula, R., Master, A., Vemuri, P., Senjem, M. L., Jones, D. T., Jack, C. R. & Josephs, K. A., Sep 2011, In : Parkinsonism and Related Disorders. 17, 8, p. 599-605 7 p.

Research output: Contribution to journalArticle

103 Scopus citations

Ecology of the aging human brain

Sonnen, J. A., Santa Cruz, K., Hemmy, L. S., Woltjer, R., Leverenz, J. B., Montine, K. S., Jack, C. R., Kaye, J., Lim, K., Larson, E. B., White, L. & Montine, T. J., Aug 2011, In : Archives of neurology. 68, 8, p. 1049-1056 8 p.

Research output: Contribution to journalArticle

101 Scopus citations

Effect of APOE ε4 status on intrinsic network connectivity in cognitively normal elderly subjects

Machulda, M. M., Jones, D. T., Vemuri, P., McDade, E., Avula, R., Przybelski, S., Boeve, B. F., Knopman, D. S., Petersen, R. C. & Jack, C. R., Sep 2011, In : Archives of neurology. 68, 9, p. 1131-1136 6 p.

Research output: Contribution to journalArticle

160 Scopus citations

Effects of hardware heterogeneity on the performance of SVM Alzheimer's disease classifier

Abdulkadir, A., Mortamet, B., Vemuri, P., Jack, C. R., Krueger, G. & Klöppel, S., Oct 1 2011, In : NeuroImage. 58, 3, p. 785-792 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Evidence for ordering of Alzheimer disease biomarkers

Jack, C. R., Vemuri, P., Wiste, H. J., Weigand, S. D., Aisen, P. S., Trojanowski, J. Q., Shaw, L. M., Bernstein, M. A., Petersen, R. C., Weiner, M. W. & Knopman, D. S., Dec 2011, In : Archives of neurology. 68, 12, p. 1526-1535 10 p.

Research output: Contribution to journalArticle

166 Scopus citations

Factors affecting Aβ plasma levels and their utility as biomarkers in ADNI

Toledo, J. B., Vanderstichele, H., Figurski, M., Aisen, P. S., Petersen, R. C., Weiner, M. W., Jack, C. R., Jagust, W., Decarli, C., Toga, A. W., Toledo, E., Xie, S. X., Lee, V. M. Y., Trojanowski, J. Q. & Shaw, L. M., Oct 2011, In : Acta neuropathologica. 122, 4, p. 401-413 13 p.

Research output: Contribution to journalArticle

104 Scopus citations

Focal brain atrophy in gastric bypass patients with cognitive complaints

Graff-Radford, J., Whitwell, J. L., Trenerry, M. R., Ahlskog, J. E., Jensen, M. D., Jack, C. R. & Josephs, K. A., Dec 2011, In : Journal of Clinical Neuroscience. 18, 12, p. 1671-1676 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Genome-wide association reveals dopamine-related genetic effects on caudate volume

Stein, J. L., Hibar, D. P., Madsen, S. K., Khamis, M., McMahon, K. L., De Zubicaray, G. I., Hansell, N. K., Montgomery, G. W., Martin, N. G., Wright, M. J., Saykin, A. J., Jack, C. R. J., Weiner, M. W., Toga, A. W. & Thompson, P. M., 2011, In : Molecular Psychiatry. 16, 9, p. 881 1 p.

Research output: Contribution to journalArticle

4 Scopus citations

Gray matter correlates of behavioral severity in progressive supranuclear palsy

Josephs, K. A., Whitwell, J. L., Eggers, S. D., Senjem, M. L. & Jack, C. R., Feb 15 2011, In : Movement Disorders. 26, 3, p. 493-498 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Harmonization of magnetic resonance-based manual hippocampal segmentation: A mandatory step for wide clinical use

Frisoni, G. B. & Jack, C. R., Mar 2011, In : Alzheimer's and Dementia. 7, 2, p. 171-174 4 p.

Research output: Contribution to journalEditorial

76 Scopus citations

Homocysteine effects on brain volumes mapped in 732 elderly individuals

Rajagopalan, P., Hua, X., Toga, A. W., Jack, C. R., Weiner, M. W. & Thompson, P. M., Jun 11 2011, In : NeuroReport. 22, 8, p. 391-395 5 p.

Research output: Contribution to journalArticle

45 Scopus citations

Identifying cognitively healthy elderly individuals with subsequent memory decline by using automated MR temporoparietal volumes

Chiang, G. C., Insel, P. S., Tosun, D., Schuff, N., Truran-Sacrey, D., Raptentsetsang, S., Jack, C. R. & Weiner, M. W., Jun 2011, In : Radiology. 259, 3, p. 844-851 8 p.

Research output: Contribution to journalArticle

34 Scopus citations
37 Scopus citations

Imaging the Alzheimer Brain

Ashford, J. W., Salehi, A., Furst, A., Bayley, P., Frisoni, G. B., Jack, C. R., Sabri, O., Adamson, M. M., Coburn, K. L., Olichney, J., Schuff, N., Spielman, D., Edland, S. D., Black, S., Rosen, A., Kennedy, D., Weiner, M. & Perry, G., 2011, In : Journal of Alzheimer's Disease. 26, SUPPL. 3, p. 1-27 27 p.

Research output: Contribution to journalReview article

18 Scopus citations

Impact of apolipoprotein ε4-cerebrospinal fluid beta-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment

Chiang, G. C., Insel, P. S., Tosun, D., Schuff, N., Truran-Sacrey, D., Raptentsetsang, S. T., Thompson, P. M., Reiman, E. M., Jack, C. R., Fox, N. C., Jagust, W. J., Harvey, D. J., Beckett, L. A., Gamst, A., Aisen, P. S., Petersen, R. C. & Weiner, M. W., Sep 2011, In : Alzheimer's and Dementia. 7, 5, p. 514-520 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

Jack, C. R., Albert, M. S., Knopman, D. S., McKhann, G. M., Sperling, R. A., Carrillo, M. C., Thies, B. & Phelps, C. H., May 2011, In : Alzheimer's and Dementia. 7, 3, p. 257-262 6 p.

Research output: Contribution to journalArticle

949 Scopus citations

Iron imaging in neurodegenerative disorders

Vemuri, P. D. & Jack, C. R. J., Jan 1 2011, Clinical MR Neuroimaging: Physiological and Functional Techniques, Second Edition. Cambridge University Press, p. 642-652 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Magnetic resonance imaging of amyloid plaques in transgenic mouse models of alzheimer's disease

Chamberlain, R., Wengenack, T. M., Poduslo, J. F., Garwood, M. & Jack, C. R., Jun 2011, In : Current Medical Imaging Reviews. 7, 1, p. 3-7 5 p.

Research output: Contribution to journalReview article

17 Scopus citations

Magnetic resonance spectroscopy, β-amyloid load, and cognition in a population-based sample of cognitively normal older adults

Kantarci, K., Lowe, V., Przybelski, S. A., Senjem, M. L., Weigand, S. D., Ivnik, R. J., Roberts, R., Geda, Y. E., Boeve, B. F., Knopman, D. S., Petersen, R. C. & Jack, C. R., Sep 6 2011, In : Neurology. 77, 10, p. 951-958 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Predicting functional decline in behavioural variant frontotemporal dementia

Josephs, K. A., Whitwell, J. L., Weigand, S. D., Senjem, M. L., Boeve, B. F., Knopman, D. S., Smith, G. E., Ivnik, R. J., Jack, C. R. & Petersen, R. C., Feb 2011, In : Brain. 134, 2, p. 432-448 17 p.

Research output: Contribution to journalArticle

30 Scopus citations

Prevalence of asymptomatic vasogenic edema in pretreatment Alzheimer's disease study cohorts from phase 3 trials of semagacestat and solanezumab

Carlson, C., Estergard, W., Oh, J., Suhy, J., Jack, C. R., Siemers, E. & Barakos, J., Jul 1 2011, In : Alzheimer's and Dementia. 7, 4, p. 396-401 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Principal components regression: Multivariate, gene-based tests in imaging genomics

Hibar, D. P., Stein, J. L., Kohannim, O., Jahanshad, N., Jack, C. R., Weiner, M. W., Toga, A. W. & Thompson, P. M., Nov 2 2011, 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11. p. 289-293 5 p. 5872408. (Proceedings - International Symposium on Biomedical Imaging).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Proton MR spectroscopy in aging and dementia

Kantarci, K. M. & Jack, C. R. J., Jan 1 2011, Clinical MR Neuroimaging: Physiological and Functional Techniques, Second Edition. Cambridge University Press, p. 618-627 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Regional differences in MRI detection of amyloid plaques in AD transgenic mouse brain

Wengenack, T. M., Reyes, D. A., Curran, G. L., Borowski, B. J., Lin, J., Preboske, G. M., Holasek, S. S., Gilles, E. J., Chamberlain, R., Marjanska, M., Jack, C. R., Garwood, M. & Poduslo, J. F., Jan 1 2011, In : NeuroImage. 54, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Reply: Multiple imputation models should incorporate the outcome in the model of interest

Weigand, S. D. & Jack, C. R., Nov 2011, In : Brain. 134, 11, p. e190

Research output: Contribution to journalLetter

1 Scopus citations

Risk factor profile for chronic kidney disease is similar to risk factor profile for small artery disease

Turner, S. T., Rule, A. D., Schwartz, G. L., Kullo, I. J., Mosley, T. H., Jack, C. R., Kardia, S. L. R., Boerwinkle, E. & Bailey, K. R., Sep 2011, In : Journal of hypertension. 29, 9, p. 1796-1801 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Section 2: Structural imaging

Bayley, P. J., Frisoni, G. B. & Jack, C. R., Dec 1 2011, Handbook of Imaging the Alzheimer Brain. Wesson Ashford, J., Rosen, A., Adamson, M., Bayley, P., Furst, A., Sabri, O., Black, S. E. & Weiner, M. (eds.). p. 45-46 2 p. (Advances in Alzheimer's Disease; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer's disease

Jack, C. R., Barkhof, F., Bernstein, M. A., Cantillon, M., Cole, P. E., Decarli, C., Dubois, B., Duchesne, S., Fox, N. C., Frisoni, G. B., Hampel, H., Hill, D. L. G., Johnson, K., Mangin, J. F., Scheltens, P., Schwarz, A. J., Sperling, R., Suhy, J., Thompson, P. M., Weiner, M. & 1 others, Foster, N. L., Jul 2011, In : Alzheimer's and Dementia. 7, 4, p. 474-485.e4

Research output: Contribution to journalComment/debate

131 Scopus citations

Survey of protocols for the manual segmentation of the hippocampus: Preparatory steps towards a joint EADC-ADNI harmonized protocol

Boccardi, M., Ganzola, R., Bocchetta, M., Pievani, M., Redolfi, A., Bartzokis, G., Camicioli, R., Csernansky, J. G., De Leon, M. J., Detoledo-Morrell, L., Killiany, R. J., Lehéricy, S., Pantel, J., Pruessner, J. C., Soininen, H., Watson, C., Duchesne, S., Jack, C. R. & Frisoni, G. B., 2011, In : Journal of Alzheimer's Disease. 26, SUPPL. 3, p. 61-75 15 p.

Research output: Contribution to journalArticle

104 Scopus citations

Survey of protocols for the manual segmentation of the hippocampus: Preparatory steps towards a joint EADC-ADNI harmonized protocol

Boccardi, M., Ganzola, R., Bocchetta, M., Pievani, M., Redolfi, A., Bartzokis, G., Camicioli, R., Csernansky, J. G., De Leon, M. J., Detoledo-Morrell, L., Killiany, R. J., Lehéricy, S., Pantel, J., Pruessner, J. C., Soininen, H., Watson, C., Duchesne, S., Jack, C. R. & Frisoni, G. B., Dec 1 2011, Handbook of Imaging the Alzheimer Brain. Wesson Ashford, J., Rosen, A., Adamson, M., Bayley, P., Furst, A., Sabri, O., Black, S. E. & Weiner, M. (eds.). p. 111-125 15 p. (Advances in Alzheimer's Disease; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Targeting vascular amyloid in arterioles of alzheimer disease transgenic mice with amyloid β protein antibody-coated nanoparticles

Poduslo, J. F., Hultman, K. L., Curran, G. L., Preboske, G. M., Chamberlain, R., Marjańska, M., Garwood, M., Jack, C. R. & Wengenack, T. M., Aug 2011, In : Journal of Neuropathology and Experimental Neurology. 70, 8, p. 653-661 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Temporoparietal atrophy: A marker of AD pathology independent of clinical diagnosis

Whitwell, J. L., Jack, C. R., Przybelski, S. A., Parisi, J. E., Senjem, M. L., Boeve, B. F., Knopman, D. S., Petersen, R. C., Dickson, D. W. & Josephs, K. A., Sep 2011, In : Neurobiology of aging. 32, 9, p. 1531-1541 11 p.

Research output: Contribution to journalArticle

65 Scopus citations