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  • Sundeep Khosla
2017

Clinical, cellular, microscopic, and ultrastructural studies of a case of fibrogenesis imperfecta ossium

Barron, M. L., Rybchyn, M. S., Ramesh, S., Mason, R. S., Fiona Bonar, S., Stalley, P., Khosla, S., Hudson, B., Arthur, C., Kim, E., Clifton-Bligh, R. J. & Clifton-Bligh, P. B., Mar 14 2017, In : Bone Research. 5, 16057.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Skeletal considerations in the medical treatment of transgender people

Khosla, S. & Davidge-Pitts, C., Dec 2019, In : The Lancet Diabetes and Endocrinology. 7, 12, p. 893-895 3 p.

Research output: Contribution to journalComment/debate

2018

Regulation of bone metabolism by sex steroids

Khosla, S. & Monroe, D. G., Jan 1 2018, In : Cold Spring Harbor perspectives in medicine. 8, 1, a031211.

Research output: Contribution to journalReview article

27 Scopus citations
2020

Aspirin and fracture risk: A systematic review and exploratory meta-analysis of observational studies

Barker, A. L., Soh, S. E., Sanders, K. M., Pasco, J., Khosla, S., Ebeling, P. R., Ward, S. A., Peeters, G., Talevski, J., Cumming, R. G., Seeman, E. & McNeil, J. J., Feb 20 2020, In : BMJ open. 10, 2, 026876.

Research output: Contribution to journalArticle

Open Access
2017

Bone diseases: Romosozumab-on track or derailed?

Khosla, S., Dec 1 2017, In : Nature Reviews Endocrinology. 13, 12, p. 697-698 2 p.

Research output: Contribution to journalShort survey

11 Scopus citations
2019

Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials

Jankowski, C. M., Wolfe, P., Schmiege, S. J., Nair, K. S., Khosla, S., Jensen, M., von Muhlen, D., Laughlin, G. A., Kritz-Silverstein, D., Bergstrom, J., Bettencourt, R., Weiss, E. P., Villareal, D. T. & Kohrt, W. M., Feb 1 2019, In : Clinical Endocrinology. 90, 2, p. 293-300 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Factors associated with proximal femur fracture determined in a large cadaveric cohort

Dragomir Daescu, M. D., Rossman, T. L., Rezaei, A., Carlson, K. D., Kallmes, D. F., Skinner, J. A., Khosla, S. & Amin, S., Nov 1 2018, In : Bone. 116, p. 196-202 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
2019
1 Scopus citations

Estrogens and progestins

Monroe, D. G. & Khosla, S., Jan 1 2019, Principles of Bone Biology. Elsevier, p. 827-837 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Operator variability in scan positioning is a major component of HR-pQCT precision error and is reduced by standardized training

Bonaretti, S., Vilayphiou, N., Chan, C. M., Yu, A., Nishiyama, K., Liu, D., Boutroy, S., Ghasem-Zadeh, A., Boyd, S. K., Chapurlat, R., McKay, H., Shane, E., Bouxsein, M. L., Black, D. M., Majumdar, S., Orwoll, E. S., Lang, T. F., Khosla, S. & Burghardt, A. J., Jul 30 2016, (Accepted/In press) In : Osteoporosis International. p. 1-13 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Technical note: Recommendations for a standard procedure to assess cortical bone at the tissue-level in vivo using impact microindentation

Diez-Perez, A., Bouxsein, M. L., Eriksen, E. F., Khosla, S., Nyman, J. S., Papapoulos, S. & Tang, S. Y., Dec 1 2016, In : Bone Reports. 5, p. 181-185 5 p.

Research output: Contribution to journalArticle

33 Scopus citations
2020

Unsupervised machine learning for the discovery of latent disease clusters and patient subgroups using electronic health records

Wang, Y., Zhao, Y., Therneau, T. M., Atkinson, E. J., Tafti, A. P., Zhang, N., Amin, S., Limper, A. H., Khosla, S. & Liu, H., Feb 2020, In : Journal of Biomedical Informatics. 102, 103364.

Research output: Contribution to journalArticle

2019

Cellular senescence in bone

Farr, J. N. & Khosla, S., Apr 2019, In : Bone. 121, p. 121-133 13 p.

Research output: Contribution to journalArticle

11 Scopus citations
2018
28 Scopus citations
2017

Fracture Incidence and Characteristics in Young Adults Aged 18 to 49 Years: A Population-Based Study

Farr, J., Melton, L. J., Achenbach, S. J., Atkinson, E. J., Khosla, S. & Amin, S., Dec 1 2017, In : Journal of Bone and Mineral Research. 32, 12, p. 2347-2354 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Determinants of bone strength and quality in diabetes mellitus in humans

Farr, J. & Khosla, S., Jan 1 2016, In : Bone. 82, p. 28-34 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

A Crisis in the Treatment of Osteoporosis

Khosla, S. & Shane, E., Aug 1 2016, In : Journal of Bone and Mineral Research. 31, 8, p. 1485-1487 3 p.

Research output: Contribution to journalEditorial

126 Scopus citations
2017

Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis

Jafari, A., Qanie, D., Andersen, T. L., Zhang, Y., Chen, L., Postert, B., Parsons, S., Ditzel, N., Khosla, S., Johansen, H. T., Kjærsgaard-Andersen, P., Delaisse, J. M., Abdallah, B. M., Hesselson, D., Solberg, R. & Kassem, M., Feb 14 2017, In : Stem Cell Reports. 8, 2, p. 373-386 14 p.

Research output: Contribution to journalArticle

28 Scopus citations
2018

Osteoprotection Through the Deletion of the Transcription Factor Rorβ in Mice

Farr, J., Weivoda, M., Nicks, K. M., Fraser, D. G., Negley, B. A., Onken, J. L., Thicke, B. S., Ruan, M., Liu, H., Forrest, D., Hawse, J. R., Khosla, S. & Monroe, D. G., Apr 1 2018, In : Journal of Bone and Mineral Research. 33, 4, p. 720-731 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2019

miR-219a-5p Regulates Rorβ During Osteoblast Differentiation and in Age-related Bone Loss

Aquino-Martinez, R., Farr, J. N., Weivoda, M. M., Negley, B. A., Onken, J. L., Thicke, B. S., Fulcer, M. M., Fraser, D. G., van Wijnen, A. J., Khosla, S. & Monroe, D. G., Jan 2019, In : Journal of Bone and Mineral Research. 34, 1, p. 135-144 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
Open Access
1 Scopus citations
2018

Aging, Obesity, and the Incidence of Diverticulitis: A Population-Based Study

Lee, T. H., Setty, P. T., Parthasarathy, G., Bailey, K. R., Wood-Wentz, C. M., Fletcher, J. G., Takahashi, N. M., Khosla, S., Moynagh, M. R., Zinsmeister, A. R. & Bharucha, A. E., Sep 1 2018, In : Mayo Clinic Proceedings. 93, 9, p. 1256-1265 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J., Xu, M., Weivoda, M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., LeBrasseur, N. K., Drake, M. M., Pignolo, R., Pirtskhalava, T., Tchkonia, T., Oursler, M. J., Kirkland, J. L. & Khosla, S., Sep 1 2017, In : Nature Medicine. 23, 9, p. 1072-1079 8 p.

Research output: Contribution to journalArticle

188 Scopus citations
2019

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. T. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., Kellogg, T. A., Khosla, S., Koerber, D. M., Lagnado, A. B., Lawson, D. K., LeBrasseur, N. K., Lerman, L. O., McDonald, K. M., McKenzie, T. J., Passos, J. F. & 13 others, Pignolo, R. J., Pirtskhalava, T., Saadiq, I. M., Schaefer, K. K., Textor, S. C., Victorelli, S. G., Volkman, T. L., Xue, A., Wentworth, M. A., Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T. & Kirkland, J. L., Sep 2019, In : EBioMedicine. 47, p. 446-456 11 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations
2020

The role of cellular senescence in ageing and endocrine disease

Khosla, S., Farr, J. N., Tchkonia, T. & Kirkland, J. L., May 1 2020, In : Nature Reviews Endocrinology. 16, 5, p. 263-275 13 p.

Research output: Contribution to journalReview article

Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes

Eckhardt, B. A., Rowsey, J. L., Thicke, B. S., Fraser, D. G., O'Grady, K. L., Bondar, O. P., Hines, J. M., Singh, R. J., Thoreson, A. R., Rakshit, K., Lagnado, A. B., Passos, J. F., Vella, A., Matveyenko, A. V., Khosla, S., Monroe, D. G. & Farr, J. N., May 7 2020, In : JCI Insight. 5, 9

Research output: Contribution to journalArticle

Open Access
2017

New hope for symptom management during natural and iatrogenic menopause transitions

Woodruff, T. K. & Khosla, S., Aug 1 2017, In : Biology of Reproduction. 97, 2, p. 177-178 2 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Advancing the Science of Healthcare Service Delivery: The NHLBI Corporate Healthcare Leaders' Panel

Sampson, U. K. A., McGlynn, E. A., Perlin, J. B., Frisse, M. E., Arnold, S. B., Benz, E. J., Brennan, T., Briss, P., Beeuwkes Buntin, M. J., Khosla, S., King, R. G., Kuntz, R., Leider, H., Ling, S. M., Macrae, J., Murray, R., Thrailkill, E., Wager, C., Witchey, D. & Jacobson, H. R., Jan 1 2018, (Accepted/In press) In : Global Heart.

Research output: Contribution to journalArticle

Proceedings of the 2018 Santa Fe Bone Symposium: Advances in the Management of Osteoporosis

Lewiecki, E. M., Bilezikian, J. P., Giangregorio, L., Greenspan, S. L., Khosla, S., Kostenuik, P., Krohn, K., McClung, M. R., Miller, P. D. & Pacifici, R., Jan 1 2018, (Accepted/In press) In : Journal of Clinical Densitometry.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Response to Stoecker et al

Khosla, S. & Shane, E., Jun 1 2017, In : Journal of Bone and Mineral Research. 32, 6, p. 1388 1 p.

Research output: Contribution to journalLetter

The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the United States: supplementary presentation

Wright, N. C., Saag, K. G., Dawson-Hughes, B., Khosla, S. & Siris, E. S., Sep 21 2017, (Accepted/In press) In : Osteoporosis International. p. 1-2 2 p.

Research output: Contribution to journalArticle

5 Scopus citations
2019

Virtual supersampling as post-processing step preserves the trabecular bone morphometry in human peripheral quantitative computed tomography scans

Schulte, F. A., Christen, P., Badilatti, S. D., Parkinson, I., Khosla, S., Goldhahn, J. & Müller, R., Feb 1 2019, In : PloS one. 14, 2, e0212280.

Research output: Contribution to journalArticle

Open Access

Personalising osteoporosis treatment for patients at high risk of fracture

Khosla, S., Oct 1 2019, In : The Lancet Diabetes and Endocrinology. 7, 10, p. 739-741 3 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Translation to Practice: Accelerating the Cycle of Innovation to Impact

Anderson, J. R., Chung, T. D. Y., Clark, L., Weis, J. A., Danielsen, A. J., Khosla, S., Gores, G. J. & Badley, A. D., Jan 1 2019, In : Mayo Clinic proceedings.

Research output: Contribution to journalReview article

1 Scopus citations
2018

Sex steroids and the pathogenesis of osteoporosis

Drake, M. M. & Khosla, S., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 412-418 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Net ankle quasi-stiffness is influenced by walking speed but not age for older adult women

Collins, J. D., Arch, E. S., Crenshaw, J. R., Bernhardt, K. A., Khosla, S., Amin, S. & Kaufman, K. R., May 1 2018, In : Gait and Posture. 62, p. 311-316 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

The relationships between compensatory stepping thresholds and measures of gait, standing postural control, strength, and balance confidence in older women

Crenshaw, J. R., Bernhardt, K. A., Atkinson, E. J., Khosla, S., Kaufman, K. R. & Amin, S., Sep 1 2018, In : Gait and Posture. 65, p. 74-80 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2020

Male mice with elevated C-type natriuretic peptide-dependent guanylyl cyclase-B activity have increased osteoblasts, bone mass and bone strength

Robinson, J. W., Blixt, N. C., Norton, A., Mansky, K. C., Ye, Z., Aparicio, C., Wagner, B. M., Benton, A. M., Warren, G. L., Khosla, S., Gaddy, D., Suva, L. J. & Potter, L. R., Jun 2020, In : Bone. 135, 115320.

Research output: Contribution to journalArticle

2016

Voxel size dependency, reproducibility and sensitivity of an in vivo bone loading estimation algorithm

Christen, P., Schulte, F. A., Zwahlen, A., Van Rietbergen, B., Boutroy, S., Melton, L. J., Amin, S., Khosla, S., Goldhahn, J. & Müller, R., Jan 1 2016, In : Journal of the Royal Society Interface. 13, 114, 20150991.

Research output: Contribution to journalArticle

13 Scopus citations
2018

Validation of a novel, rapid, high precision sclerostin assay not confounded by sclerostin fragments

Drake, M. M., Fenske, J. S., Blocki, F. A., Zierold, C., Appelman-Dijkstra, N., Papapoulos, S. & Khosla, S., Jun 1 2018, In : Bone. 111, p. 36-43 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Skeletal metabolism, fracture risk, and fracture outcomes in type 1 and type 2 diabetes

Sellmeyer, D. E., Civitelli, R., Hofbauer, L. C., Khosla, S., Lecka-Czernik, B. & Schwartz, A. V., Jul 1 2016, In : Diabetes. 65, 7, p. 1757-1766 10 p.

Research output: Contribution to journalReview article

56 Scopus citations

Hormonal and systemic regulation of sclerostin

Drake, M. M. & Khosla, S., Jul 28 2016, (Accepted/In press) In : Bone.

Research output: Contribution to journalArticle

25 Scopus citations

The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the USA

Wright, N. C., Saag, K. G., Dawson-Hughes, B., Khosla, S. & Siris, E. S., Dec 13 2016, (Accepted/In press) In : Osteoporosis International. p. 1-8 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: Protocol for the ASPREE-Fracture substudy

ASPREE Investigator Group, Aug 2016, In : Injury Prevention. 22, 4, p. 297-301 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
2019

Is It Time to Stop (or Pause) Vertebral Augmentation?

Clarke, B. L. & Khosla, S., Jan 2019, In : Journal of Bone and Mineral Research. 34, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

2 Scopus citations
2017

Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned

Drake, M. M., Clarke, B., Oursler, M. J. & Khosla, S., Aug 1 2017, In : Endocrine Reviews. 38, 4, p. 325-350 26 p.

Research output: Contribution to journalReview article

50 Scopus citations
2018

Osteoporosis and Hip Fracture Risk From Routine Computed Tomography Scans: The Fracture, Osteoporosis, and CT Utilization Study (FOCUS)

Adams, A. L., Fischer, H., Kopperdahl, D. L., Lee, D. C., Black, D. M., Bouxsein, M. L., Fatemi, S., Khosla, S., Orwoll, E. S., Siris, E. S. & Keaveny, T. M., Jul 2018, In : Journal of Bone and Mineral Research. 33, 7, p. 1291-1301 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
2017

Circulating osteogenic endothelial progenitor cell counts: new biomarker for the severity of coronary artery disease

Yang, S. W., Hennessy, R. R., Khosla, S., Lennon, R., Loeffler, D., Sun, T., Liu, Z., Park, K. H., Wang, F. L., Lerman, L. O. & Lerman, A., Jan 15 2017, In : International Journal of Cardiology. 227, p. 833-839 7 p.

Research output: Contribution to journalArticle

12 Scopus citations
2019

Circulating Osteogenic Progenitor Cells in Mild, Moderate, and Severe Aortic Valve Stenosis

Al-Hijji, M., Narula, N., Go, J. L., Khosla, S., Sarano, M. E., Loeffler, D., Lennon, R., Lerman, L. O. & Lerman, A., Apr 1 2019, In : Mayo Clinic proceedings. 94, 4, p. 652-659 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Bone quality in type 2 diabetes mellitus

Farr, J. & Khosla, S., Jan 1 2016, Diabetic Bone Disease: Basic and Translational Research and Clinical Applications. Springer International Publishing, p. 211-224 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter