6q deletion in Waldenström macroglobulinemia is associated with features of adverse prognosis

E. M. Ocio, R. F J Schop, B. Gonzalez, S. A. Van Wier, J. M. Hernandez-Rivas, N. C. Gutierrez, R. Garcia-Sanz, M. J. Moro, C. Aguilera, J. Hernandez, R. Xu, P. R. Greipp, Angela Dispenzieri, S. M. Jalal, Martha Lacy, N. Gonzalez-Paz, Morie Gertz, J. F. San Miguel, Rafael Fonseca

Research output: Contribution to journalArticle

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Abstract

Fluorescence in situ hybridisation (FISH) is an effective technique for the cytogenetic analysis of Waldenström macroglobulinemia (WM), but the potential impact of molecular cytogenetics on disease evolution and as a prognostic marker is still unknown. Deletion of the long arm of chromosome 6 (6q-) is the most frequent cytogenetic abnormality in WM. This study analysed the prevalence of this aberration in 102 WM patients, and correlated it with disease characteristics. The incidence of 6q21 deletion was 7% by conventional cytogenetics and 34% when analysed by FISH (54% when cytoplasmic immunoglobulin M-FISH was used). Patients with deletion of 6q displayed features of adverse prognosis, such as higher levels of β2-microglobulin and monoclonal paraprotein and a greater tendency to display anaemia and hypoalbuminemia. Interestingly, there was a correlation between the presence of 6q deletion and the International Staging System prognostic index (incidence of 6q- among patients stratified in stages 1, 2 and 3 was 24%, 42% and 67% respectively). Those patients diagnosed with smouldering WM who displayed the abnormality showed a trend to an earlier requirement of treatment. Finally, the survival analysis did not show differences between the two groups of patients, probably due to the short follow up of our series.

Original languageEnglish (US)
Pages (from-to)80-86
Number of pages7
JournalBritish Journal of Haematology
Volume136
Issue number1
DOIs
StatePublished - Jan 2007

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Waldenstrom Macroglobulinemia
Fluorescence In Situ Hybridization
Cytogenetics
Paraproteins
Hypoalbuminemia
Chromosomes, Human, Pair 6
Cytogenetic Analysis
Incidence
Survival Analysis
Chromosome Aberrations
Immunoglobulin M
Anemia
Cross-Sectional Studies
Monosomy 6q Chromosome 6

Keywords

  • 6q deletion
  • DNA deletions
  • Fluorescence in situ hybridisation
  • Prognostic
  • Waldenström macroglobulinemia

ASJC Scopus subject areas

  • Hematology

Cite this

Ocio, E. M., Schop, R. F. J., Gonzalez, B., Van Wier, S. A., Hernandez-Rivas, J. M., Gutierrez, N. C., ... Fonseca, R. (2007). 6q deletion in Waldenström macroglobulinemia is associated with features of adverse prognosis. British Journal of Haematology, 136(1), 80-86. https://doi.org/10.1111/j.1365-2141.2006.06389.x

6q deletion in Waldenström macroglobulinemia is associated with features of adverse prognosis. / Ocio, E. M.; Schop, R. F J; Gonzalez, B.; Van Wier, S. A.; Hernandez-Rivas, J. M.; Gutierrez, N. C.; Garcia-Sanz, R.; Moro, M. J.; Aguilera, C.; Hernandez, J.; Xu, R.; Greipp, P. R.; Dispenzieri, Angela; Jalal, S. M.; Lacy, Martha; Gonzalez-Paz, N.; Gertz, Morie; San Miguel, J. F.; Fonseca, Rafael.

In: British Journal of Haematology, Vol. 136, No. 1, 01.2007, p. 80-86.

Research output: Contribution to journalArticle

Ocio, EM, Schop, RFJ, Gonzalez, B, Van Wier, SA, Hernandez-Rivas, JM, Gutierrez, NC, Garcia-Sanz, R, Moro, MJ, Aguilera, C, Hernandez, J, Xu, R, Greipp, PR, Dispenzieri, A, Jalal, SM, Lacy, M, Gonzalez-Paz, N, Gertz, M, San Miguel, JF & Fonseca, R 2007, '6q deletion in Waldenström macroglobulinemia is associated with features of adverse prognosis', British Journal of Haematology, vol. 136, no. 1, pp. 80-86. https://doi.org/10.1111/j.1365-2141.2006.06389.x
Ocio, E. M. ; Schop, R. F J ; Gonzalez, B. ; Van Wier, S. A. ; Hernandez-Rivas, J. M. ; Gutierrez, N. C. ; Garcia-Sanz, R. ; Moro, M. J. ; Aguilera, C. ; Hernandez, J. ; Xu, R. ; Greipp, P. R. ; Dispenzieri, Angela ; Jalal, S. M. ; Lacy, Martha ; Gonzalez-Paz, N. ; Gertz, Morie ; San Miguel, J. F. ; Fonseca, Rafael. / 6q deletion in Waldenström macroglobulinemia is associated with features of adverse prognosis. In: British Journal of Haematology. 2007 ; Vol. 136, No. 1. pp. 80-86.
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abstract = "Fluorescence in situ hybridisation (FISH) is an effective technique for the cytogenetic analysis of Waldenstr{\"o}m macroglobulinemia (WM), but the potential impact of molecular cytogenetics on disease evolution and as a prognostic marker is still unknown. Deletion of the long arm of chromosome 6 (6q-) is the most frequent cytogenetic abnormality in WM. This study analysed the prevalence of this aberration in 102 WM patients, and correlated it with disease characteristics. The incidence of 6q21 deletion was 7{\%} by conventional cytogenetics and 34{\%} when analysed by FISH (54{\%} when cytoplasmic immunoglobulin M-FISH was used). Patients with deletion of 6q displayed features of adverse prognosis, such as higher levels of β2-microglobulin and monoclonal paraprotein and a greater tendency to display anaemia and hypoalbuminemia. Interestingly, there was a correlation between the presence of 6q deletion and the International Staging System prognostic index (incidence of 6q- among patients stratified in stages 1, 2 and 3 was 24{\%}, 42{\%} and 67{\%} respectively). Those patients diagnosed with smouldering WM who displayed the abnormality showed a trend to an earlier requirement of treatment. Finally, the survival analysis did not show differences between the two groups of patients, probably due to the short follow up of our series.",
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AU - Ocio, E. M.

AU - Schop, R. F J

AU - Gonzalez, B.

AU - Van Wier, S. A.

AU - Hernandez-Rivas, J. M.

AU - Gutierrez, N. C.

AU - Garcia-Sanz, R.

AU - Moro, M. J.

AU - Aguilera, C.

AU - Hernandez, J.

AU - Xu, R.

AU - Greipp, P. R.

AU - Dispenzieri, Angela

AU - Jalal, S. M.

AU - Lacy, Martha

AU - Gonzalez-Paz, N.

AU - Gertz, Morie

AU - San Miguel, J. F.

AU - Fonseca, Rafael

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