6-Aminohexanoic acid-plasminogen interactions studied by fluorescence

S. Vuk-Pavlović, A. Gafni

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Circular polarization of luminescence spectra of human plasminogen and of its derivatives were measured in solutions of ligand-free proteins and with saturating amounts of 6-aminohexanoic acid. Spectroscopic changes induced by the ligand reveal similar perturbations of the binding sites in all the protein derivatives. It is concluded that the gross conformational change induced by 6-aminohexanoic acid binding to the native plasminogen involves changes of sterical relations of entire protein domains.

Original languageEnglish (US)
Pages (from-to)971-975
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume91
Issue number3
DOIs
StatePublished - Dec 14 1979

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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