5-hydroxytryptamine signalling in irritable bowel syndrome with diarrhoea

Effects of gender and menstrual status

L. A. Houghton, H. Brown, W. Atkinson, J. Morris, C. Fell, P. J. Whorwell, S. Lockhart, B. Keevil

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Symptomatology and physiology differ between men and women and across the menstrual cycle in irritable bowel syndrome (IBS). Ovarian hormones influence 5-hydroxytryptamine (5-HT), an amine known to play a role in gut motor-sensory function. Aim To assess the effects of gender and menstrual status on platelet-depleted plasma (PDP) 5-HT concentration in IBS patients with diarrhoea (IBS-D) patients compared with healthy volunteers (HV). Methods Platelet-depleted plasma 5-HT concentrations were assessed under fasting and fed conditions in 73 IBS-D patients (aged 18-58 years; 18 men) and 64 HV (aged 18-50 years; 24 men). Women were divided into those with low or high progesterone/oestrogen (P/O) levels. Results Irritable bowel syndrome patients with diarrhoea had higher PDP 5-HT concentrations than HV under fasting (P = 0.002) and fed (P = 0.049) conditions. This was particularly related to IBS-D men having higher PDP 5-HT concentrations than healthy controls (P = 0.002). Moreover, PDP 5-HT concentrations in IBS-D women with low P/O levels were similar to healthy controls. Conclusions Similar to IBS-D women with high P/O levels, IBS-D men also have raised PDP 5-HT concentrations. 5-HT concentration normalizes at menses in IBS-D women, suggesting a shift in the mechanisms responsible for abnormal 5-HT signalling in these patients.

Original languageEnglish (US)
Pages (from-to)919-929
Number of pages11
JournalAlimentary Pharmacology and Therapeutics
Volume30
Issue number9
DOIs
StatePublished - Nov 2009
Externally publishedYes

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Irritable Bowel Syndrome
Diarrhea
Serotonin
Blood Platelets
Progesterone
Healthy Volunteers
Estrogens
Fasting
Menstruation
Menstrual Cycle
Amines
Hormones

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

5-hydroxytryptamine signalling in irritable bowel syndrome with diarrhoea : Effects of gender and menstrual status. / Houghton, L. A.; Brown, H.; Atkinson, W.; Morris, J.; Fell, C.; Whorwell, P. J.; Lockhart, S.; Keevil, B.

In: Alimentary Pharmacology and Therapeutics, Vol. 30, No. 9, 11.2009, p. 919-929.

Research output: Contribution to journalArticle

Houghton, LA, Brown, H, Atkinson, W, Morris, J, Fell, C, Whorwell, PJ, Lockhart, S & Keevil, B 2009, '5-hydroxytryptamine signalling in irritable bowel syndrome with diarrhoea: Effects of gender and menstrual status', Alimentary Pharmacology and Therapeutics, vol. 30, no. 9, pp. 919-929. https://doi.org/10.1111/j.1365-2036.2009.04121.x
Houghton, L. A. ; Brown, H. ; Atkinson, W. ; Morris, J. ; Fell, C. ; Whorwell, P. J. ; Lockhart, S. ; Keevil, B. / 5-hydroxytryptamine signalling in irritable bowel syndrome with diarrhoea : Effects of gender and menstrual status. In: Alimentary Pharmacology and Therapeutics. 2009 ; Vol. 30, No. 9. pp. 919-929.
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