TY - JOUR
T1 - 5-HT and the brain-gut axis
T2 - Opportunities for pharmacologic intervention
AU - Crowell, Michael D.
AU - Wessinger, Sarah B.
PY - 2007/6
Y1 - 2007/6
N2 - Interactions between the enteric nervous system of the gut and the brain occur bidirectionally over sympathetic and parasympathetic pathways. Coordinated actions of the central, autonomic and enteric nervous systems modulate intestinal motor, sensory and secretory activities by neuro-modulators, including 5-HT, noradrenaline and dopamine. 5-HT is an important signaling molecule in the brain-gut axis and the 5-HT released from enterochromaffin cells modulates peristaltic, secretory, vasodilatory, vagal and nociceptive reflexes. Irritable bowel syndrome is associated with altered motility, secretion and sensation; enteric 5-HT signaling may be defective in this disorder. In this editorial, recent data are reviewed and the potential for the development of pharmacologic intervention is assessed.
AB - Interactions between the enteric nervous system of the gut and the brain occur bidirectionally over sympathetic and parasympathetic pathways. Coordinated actions of the central, autonomic and enteric nervous systems modulate intestinal motor, sensory and secretory activities by neuro-modulators, including 5-HT, noradrenaline and dopamine. 5-HT is an important signaling molecule in the brain-gut axis and the 5-HT released from enterochromaffin cells modulates peristaltic, secretory, vasodilatory, vagal and nociceptive reflexes. Irritable bowel syndrome is associated with altered motility, secretion and sensation; enteric 5-HT signaling may be defective in this disorder. In this editorial, recent data are reviewed and the potential for the development of pharmacologic intervention is assessed.
KW - 5-HT
KW - Autonomic nervous system
KW - Brain-gut axis
KW - Irritable bowel syndrome
UR - http://www.scopus.com/inward/record.url?scp=34250023482&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34250023482&partnerID=8YFLogxK
U2 - 10.1517/13543784.16.6.761
DO - 10.1517/13543784.16.6.761
M3 - Editorial
C2 - 17501688
AN - SCOPUS:34250023482
SN - 1354-3784
VL - 16
SP - 761
EP - 765
JO - Expert Opinion on Investigational Drugs
JF - Expert Opinion on Investigational Drugs
IS - 6
ER -