5-Fluorocytosine susceptibility of pathogenic fungi in the presence of allopurinol: Potential for improving the therapeutic index of 5-fluorocytosine

T. M. Kerkering, P. M. Schwartz, A. Espinel-Ingroff, P. J. Turek, R. B. Diasio

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The minimal inhibitory concentration of 5-fluorocytosine in 18 pathogenic fungal isolates was not altered by either allopurinol (100 μM) or oxypurinol (100 μM). Since allopurinol at this level clinically has been demonstrated to interfere with 5-fluorouracil anabolism, thereby reducing toxicity owing to 5-fluorouracil, allopurinol may be useful in counteracting the 5-fluorouracil-induced myelotoxicity observed in patients being treated with 5-fluorocytosine without interfering with the antifungal activity of 5-fluorocytosine.

Original languageEnglish (US)
Pages (from-to)448-449
Number of pages2
JournalUnknown Journal
Volume24
Issue number3
DOIs
StatePublished - Jan 1 1983

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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