5-Fluorocytosine susceptibility of pathogenic fungi in the presence of allopurinol: Potential for improving the therapeutic index of 5-fluorocytosine

T. M. Kerkering; P. M. Schwartz; A. Espinel-Ingroff; P. J. Turek; R. B. Diasio

doi:10.1128/AAC.24.3.448

5-Fluorocytosine susceptibility of pathogenic fungi in the presence of allopurinol: Potential for improving the therapeutic index of 5-fluorocytosine

T. M. Kerkering, P. M. Schwartz, A. Espinel-Ingroff, P. J. Turek, R. B. Diasio

Pharmacology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The minimal inhibitory concentration of 5-fluorocytosine in 18 pathogenic fungal isolates was not altered by either allopurinol (100 μM) or oxypurinol (100 μM). Since allopurinol at this level clinically has been demonstrated to interfere with 5-fluorouracil anabolism, thereby reducing toxicity owing to 5-fluorouracil, allopurinol may be useful in counteracting the 5-fluorouracil-induced myelotoxicity observed in patients being treated with 5-fluorocytosine without interfering with the antifungal activity of 5-fluorocytosine.

Original language	English (US)
Pages (from-to)	448-449
Number of pages	2
Journal	Unknown Journal
Volume	24
Issue number	3
DOIs	https://doi.org/10.1128/AAC.24.3.448
State	Published - 1983

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.24.3.448

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title = "5-Fluorocytosine susceptibility of pathogenic fungi in the presence of allopurinol: Potential for improving the therapeutic index of 5-fluorocytosine",

abstract = "The minimal inhibitory concentration of 5-fluorocytosine in 18 pathogenic fungal isolates was not altered by either allopurinol (100 μM) or oxypurinol (100 μM). Since allopurinol at this level clinically has been demonstrated to interfere with 5-fluorouracil anabolism, thereby reducing toxicity owing to 5-fluorouracil, allopurinol may be useful in counteracting the 5-fluorouracil-induced myelotoxicity observed in patients being treated with 5-fluorocytosine without interfering with the antifungal activity of 5-fluorocytosine.",

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T1 - 5-Fluorocytosine susceptibility of pathogenic fungi in the presence of allopurinol

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AU - Schwartz, P. M.

AU - Espinel-Ingroff, A.

AU - Turek, P. J.

AU - Diasio, R. B.

PY - 1983

Y1 - 1983

N2 - The minimal inhibitory concentration of 5-fluorocytosine in 18 pathogenic fungal isolates was not altered by either allopurinol (100 μM) or oxypurinol (100 μM). Since allopurinol at this level clinically has been demonstrated to interfere with 5-fluorouracil anabolism, thereby reducing toxicity owing to 5-fluorouracil, allopurinol may be useful in counteracting the 5-fluorouracil-induced myelotoxicity observed in patients being treated with 5-fluorocytosine without interfering with the antifungal activity of 5-fluorocytosine.

AB - The minimal inhibitory concentration of 5-fluorocytosine in 18 pathogenic fungal isolates was not altered by either allopurinol (100 μM) or oxypurinol (100 μM). Since allopurinol at this level clinically has been demonstrated to interfere with 5-fluorouracil anabolism, thereby reducing toxicity owing to 5-fluorouracil, allopurinol may be useful in counteracting the 5-fluorouracil-induced myelotoxicity observed in patients being treated with 5-fluorocytosine without interfering with the antifungal activity of 5-fluorocytosine.

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5-Fluorocytosine susceptibility of pathogenic fungi in the presence of allopurinol: Potential for improving the therapeutic index of 5-fluorocytosine

Abstract

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