40 years of IGF1: PAPP-A and cancer

Cheryl A. Conover, Claus Oxvig

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

The zinc metalloproteinase, PAPP-A, enhances local insulin-like growth factor (IGF) action through cleavage of inhibitory IGF-binding proteins, thereby increasing IGF available for IGF receptor-mediated cell proliferation, migration and survival. In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and function, and post-translational inhibitors of PAPP-A expression or proteolytic activity. We will then review the evidence supporting an important role for PAPP-A in many cancers, including breast, ovarian and lung cancer, and Ewing sarcoma.

Original languageEnglish (US)
Pages (from-to)T1-T10
JournalJournal of Molecular Endocrinology
Volume61
Issue number1
DOIs
StatePublished - Jul 2018

Keywords

  • Breast cancer
  • Ewing sarcoma
  • Insulin-like growth factor
  • Lung cancer
  • Melanoma
  • Mesothelioma
  • Ovarian cancer
  • Pregnancy-associated plasma protein-A
  • Stanniocalcin

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

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