40 years of IGF1

PAPP-A and cancer

Cheryl A Conover, Claus Oxvig

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The zinc metalloproteinase, PAPP-A, enhances local insulin-like growth factor (IGF) action through cleavage of inhibitory IGF-binding proteins, thereby increasing IGF available for IGF receptor-mediated cell proliferation, migration and survival. In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and function, and post-translational inhibitors of PAPP-A expression or proteolytic activity. We will then review the evidence supporting an important role for PAPP-A in many cancers, including breast, ovarian and lung cancer, and Ewing sarcoma.

Original languageEnglish (US)
Pages (from-to)T1-T10
JournalJournal of Molecular Endocrinology
Volume61
Issue number1
DOIs
StatePublished - Jul 1 2018

Fingerprint

Pregnancy-Associated Plasma Protein-A
Somatomedin Receptors
Somatomedins
Lung Neoplasms
Neoplasms
Breast Neoplasms
Insulin-Like Growth Factor Binding Proteins
Ewing's Sarcoma
Metalloproteases
Ovarian Neoplasms
Cell Movement
Zinc
Cell Survival
Cell Proliferation
Neoplasm Metastasis
Growth

Keywords

  • Breast cancer
  • Ewing sarcoma
  • Insulin-like growth factor
  • Lung cancer
  • Melanoma
  • Mesothelioma
  • Ovarian cancer
  • Pregnancy-associated plasma protein-A
  • Stanniocalcin

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

Cite this

40 years of IGF1 : PAPP-A and cancer. / Conover, Cheryl A; Oxvig, Claus.

In: Journal of Molecular Endocrinology, Vol. 61, No. 1, 01.07.2018, p. T1-T10.

Research output: Contribution to journalReview article

Conover, Cheryl A ; Oxvig, Claus. / 40 years of IGF1 : PAPP-A and cancer. In: Journal of Molecular Endocrinology. 2018 ; Vol. 61, No. 1. pp. T1-T10.
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