Abstract
The zinc metalloproteinase, PAPP-A, enhances local insulin-like growth factor (IGF) action through cleavage of inhibitory IGF-binding proteins, thereby increasing IGF available for IGF receptor-mediated cell proliferation, migration and survival. In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and function, and post-translational inhibitors of PAPP-A expression or proteolytic activity. We will then review the evidence supporting an important role for PAPP-A in many cancers, including breast, ovarian and lung cancer, and Ewing sarcoma.
Original language | English (US) |
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Pages (from-to) | T1-T10 |
Journal | Journal of Molecular Endocrinology |
Volume | 61 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2018 |
Keywords
- Breast cancer
- Ewing sarcoma
- Insulin-like growth factor
- Lung cancer
- Melanoma
- Mesothelioma
- Ovarian cancer
- Pregnancy-associated plasma protein-A
- Stanniocalcin
ASJC Scopus subject areas
- Molecular Biology
- Endocrinology