3D Bioprinting for Tissue and Organ Fabrication

Yu Shrike Zhang, Kan Yue, Julio Aleman, Kamyar Mollazadeh-Moghaddam, Syeda Mahwish Bakht, Jingzhou Yang, Weitao Jia, Valeria Dell’Erba, Pribpandao Assawes, Su Ryon Shin, Mehmet Remzi Dokmeci, Rahmi Oklu, Ali Khademhosseini

Research output: Contribution to journalArticlepeer-review

198 Scopus citations

Abstract

The field of regenerative medicine has progressed tremendously over the past few decades in its ability to fabricate functional tissue substitutes. Conventional approaches based on scaffolding and microengineering are limited in their capacity of producing tissue constructs with precise biomimetic properties. Three-dimensional (3D) bioprinting technology, on the other hand, promises to bridge the divergence between artificially engineered tissue constructs and native tissues. In a sense, 3D bioprinting offers unprecedented versatility to co-deliver cells and biomaterials with precise control over their compositions, spatial distributions, and architectural accuracy, therefore achieving detailed or even personalized recapitulation of the fine shape, structure, and architecture of target tissues and organs. Here we briefly describe recent progresses of 3D bioprinting technology and associated bioinks suitable for the printing process. We then focus on the applications of this technology in fabrication of biomimetic constructs of several representative tissues and organs, including blood vessel, heart, liver, and cartilage. We finally conclude with future challenges in 3D bioprinting as well as potential solutions for further development.

Original languageEnglish (US)
Pages (from-to)148-163
Number of pages16
JournalAnnals of Biomedical Engineering
Volume45
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • Additive manufacturing
  • Bioink
  • Bioprinting
  • Regenerative medicine
  • Tissue engineering

ASJC Scopus subject areas

  • Biomedical Engineering

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