Abstract
The field of regenerative medicine has progressed tremendously over the past few decades in its ability to fabricate functional tissue substitutes. Conventional approaches based on scaffolding and microengineering are limited in their capacity of producing tissue constructs with precise biomimetic properties. Three-dimensional (3D) bioprinting technology, on the other hand, promises to bridge the divergence between artificially engineered tissue constructs and native tissues. In a sense, 3D bioprinting offers unprecedented versatility to co-deliver cells and biomaterials with precise control over their compositions, spatial distributions, and architectural accuracy, therefore achieving detailed or even personalized recapitulation of the fine shape, structure, and architecture of target tissues and organs. Here we briefly describe recent progresses of 3D bioprinting technology and associated bioinks suitable for the printing process. We then focus on the applications of this technology in fabrication of biomimetic constructs of several representative tissues and organs, including blood vessel, heart, liver, and cartilage. We finally conclude with future challenges in 3D bioprinting as well as potential solutions for further development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-16 |
| Number of pages | 16 |
| Journal | Annals of Biomedical Engineering |
| DOIs | |
| State | Accepted/In press - Apr 28 2016 |
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Keywords
- Additive manufacturing
- Bioink
- Bioprinting
- Regenerative medicine
- Tissue engineering
ASJC Scopus subject areas
- Biomedical Engineering
Cite this
3D Bioprinting for Tissue and Organ Fabrication. / Zhang, Yu Shrike; Yue, Kan; Aleman, Julio; Mollazadeh-Moghaddam, Kamyar; Bakht, Syeda Mahwish; Yang, Jingzhou; Jia, Weitao; Dell’Erba, Valeria; Assawes, Pribpandao; Shin, Su Ryon; Dokmeci, Mehmet Remzi; Oklu, Rahmi; Khademhosseini, Ali.
In: Annals of Biomedical Engineering, 28.04.2016, p. 1-16.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 3D Bioprinting for Tissue and Organ Fabrication
AU - Zhang, Yu Shrike
AU - Yue, Kan
AU - Aleman, Julio
AU - Mollazadeh-Moghaddam, Kamyar
AU - Bakht, Syeda Mahwish
AU - Yang, Jingzhou
AU - Jia, Weitao
AU - Dell’Erba, Valeria
AU - Assawes, Pribpandao
AU - Shin, Su Ryon
AU - Dokmeci, Mehmet Remzi
AU - Oklu, Rahmi
AU - Khademhosseini, Ali
PY - 2016/4/28
Y1 - 2016/4/28
N2 - The field of regenerative medicine has progressed tremendously over the past few decades in its ability to fabricate functional tissue substitutes. Conventional approaches based on scaffolding and microengineering are limited in their capacity of producing tissue constructs with precise biomimetic properties. Three-dimensional (3D) bioprinting technology, on the other hand, promises to bridge the divergence between artificially engineered tissue constructs and native tissues. In a sense, 3D bioprinting offers unprecedented versatility to co-deliver cells and biomaterials with precise control over their compositions, spatial distributions, and architectural accuracy, therefore achieving detailed or even personalized recapitulation of the fine shape, structure, and architecture of target tissues and organs. Here we briefly describe recent progresses of 3D bioprinting technology and associated bioinks suitable for the printing process. We then focus on the applications of this technology in fabrication of biomimetic constructs of several representative tissues and organs, including blood vessel, heart, liver, and cartilage. We finally conclude with future challenges in 3D bioprinting as well as potential solutions for further development.
AB - The field of regenerative medicine has progressed tremendously over the past few decades in its ability to fabricate functional tissue substitutes. Conventional approaches based on scaffolding and microengineering are limited in their capacity of producing tissue constructs with precise biomimetic properties. Three-dimensional (3D) bioprinting technology, on the other hand, promises to bridge the divergence between artificially engineered tissue constructs and native tissues. In a sense, 3D bioprinting offers unprecedented versatility to co-deliver cells and biomaterials with precise control over their compositions, spatial distributions, and architectural accuracy, therefore achieving detailed or even personalized recapitulation of the fine shape, structure, and architecture of target tissues and organs. Here we briefly describe recent progresses of 3D bioprinting technology and associated bioinks suitable for the printing process. We then focus on the applications of this technology in fabrication of biomimetic constructs of several representative tissues and organs, including blood vessel, heart, liver, and cartilage. We finally conclude with future challenges in 3D bioprinting as well as potential solutions for further development.
KW - Additive manufacturing
KW - Bioink
KW - Bioprinting
KW - Regenerative medicine
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=84964440193&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964440193&partnerID=8YFLogxK
U2 - 10.1007/s10439-016-1612-8
DO - 10.1007/s10439-016-1612-8
M3 - Article
C2 - 27126775
AN - SCOPUS:84964440193
SP - 1
EP - 16
JO - Annals of Biomedical Engineering
JF - Annals of Biomedical Engineering
SN - 0090-6964
ER -