3 T deep gray matter T2 hypointensity correlates with disability over time in stable relapsing-remitting multiple sclerosis

A 3-year pilot study

Y. Zhang, L. M. Metz, V. W. Yong, Joseph Ross Mitchell

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Abnormally decreased deep gray matter (GM) signal intensity on T2-weighted MRI (T2 hypointensity) is associated with brain atrophy and disability progression in patients with multiple sclerosis (MS) and is believed to represent excessive iron deposition. We investigated the time course of deep GM T2 hypointensity and its relationship with disability at 3 T in 8 stable relapsing-remitting (RR) MS patients treated with minocycline over 3 years. MRI and disability measurements were compared at baseline, 6, 12, 24, and 36 months. Grand mean deep GM T2 hypointensity was negatively correlated with EDSS over time (r = - 0.94, P = 0.02). This correlation was strongest in the head of caudate (r = - 0.95, P = 0.01) and putamen (r = - 0.89, P = 0.04). Additionally, baseline grand mean deep GM T2 hypointensity appears to predict third year EDSS (r = - 0.72, P = 0.04). These results suggest that iron associated deep GM injury correlates with patient disability in stable RRMS. Measurements of deep GM T2 hypointensity at high field MRI may prove to be useful in monitoring individuals with MS. Further studies are required to confirm these results in a large sample and to determine if T2 hypointensity changes in clinically active MS patients.

Original languageEnglish (US)
Pages (from-to)76-81
Number of pages6
JournalJournal of the Neurological Sciences
Volume297
Issue number1-2
DOIs
StatePublished - Oct 15 2010
Externally publishedYes

Fingerprint

Relapsing-Remitting Multiple Sclerosis
Multiple Sclerosis
Iron
Minocycline
Putamen
Atrophy
Gray Matter
Wounds and Injuries
Brain

Keywords

  • 3 T MRI
  • Deep gray matter
  • Disability
  • Iron deposition
  • Multiple sclerosis
  • T2 hypointensity
  • Time course

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

3 T deep gray matter T2 hypointensity correlates with disability over time in stable relapsing-remitting multiple sclerosis : A 3-year pilot study. / Zhang, Y.; Metz, L. M.; Yong, V. W.; Mitchell, Joseph Ross.

In: Journal of the Neurological Sciences, Vol. 297, No. 1-2, 15.10.2010, p. 76-81.

Research output: Contribution to journalArticle

@article{e2497ac0c61741d9a8f101c3b8c9a9c2,
title = "3 T deep gray matter T2 hypointensity correlates with disability over time in stable relapsing-remitting multiple sclerosis: A 3-year pilot study",
abstract = "Abnormally decreased deep gray matter (GM) signal intensity on T2-weighted MRI (T2 hypointensity) is associated with brain atrophy and disability progression in patients with multiple sclerosis (MS) and is believed to represent excessive iron deposition. We investigated the time course of deep GM T2 hypointensity and its relationship with disability at 3 T in 8 stable relapsing-remitting (RR) MS patients treated with minocycline over 3 years. MRI and disability measurements were compared at baseline, 6, 12, 24, and 36 months. Grand mean deep GM T2 hypointensity was negatively correlated with EDSS over time (r = - 0.94, P = 0.02). This correlation was strongest in the head of caudate (r = - 0.95, P = 0.01) and putamen (r = - 0.89, P = 0.04). Additionally, baseline grand mean deep GM T2 hypointensity appears to predict third year EDSS (r = - 0.72, P = 0.04). These results suggest that iron associated deep GM injury correlates with patient disability in stable RRMS. Measurements of deep GM T2 hypointensity at high field MRI may prove to be useful in monitoring individuals with MS. Further studies are required to confirm these results in a large sample and to determine if T2 hypointensity changes in clinically active MS patients.",
keywords = "3 T MRI, Deep gray matter, Disability, Iron deposition, Multiple sclerosis, T2 hypointensity, Time course",
author = "Y. Zhang and Metz, {L. M.} and Yong, {V. W.} and Mitchell, {Joseph Ross}",
year = "2010",
month = "10",
day = "15",
doi = "10.1016/j.jns.2010.07.014",
language = "English (US)",
volume = "297",
pages = "76--81",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - 3 T deep gray matter T2 hypointensity correlates with disability over time in stable relapsing-remitting multiple sclerosis

T2 - A 3-year pilot study

AU - Zhang, Y.

AU - Metz, L. M.

AU - Yong, V. W.

AU - Mitchell, Joseph Ross

PY - 2010/10/15

Y1 - 2010/10/15

N2 - Abnormally decreased deep gray matter (GM) signal intensity on T2-weighted MRI (T2 hypointensity) is associated with brain atrophy and disability progression in patients with multiple sclerosis (MS) and is believed to represent excessive iron deposition. We investigated the time course of deep GM T2 hypointensity and its relationship with disability at 3 T in 8 stable relapsing-remitting (RR) MS patients treated with minocycline over 3 years. MRI and disability measurements were compared at baseline, 6, 12, 24, and 36 months. Grand mean deep GM T2 hypointensity was negatively correlated with EDSS over time (r = - 0.94, P = 0.02). This correlation was strongest in the head of caudate (r = - 0.95, P = 0.01) and putamen (r = - 0.89, P = 0.04). Additionally, baseline grand mean deep GM T2 hypointensity appears to predict third year EDSS (r = - 0.72, P = 0.04). These results suggest that iron associated deep GM injury correlates with patient disability in stable RRMS. Measurements of deep GM T2 hypointensity at high field MRI may prove to be useful in monitoring individuals with MS. Further studies are required to confirm these results in a large sample and to determine if T2 hypointensity changes in clinically active MS patients.

AB - Abnormally decreased deep gray matter (GM) signal intensity on T2-weighted MRI (T2 hypointensity) is associated with brain atrophy and disability progression in patients with multiple sclerosis (MS) and is believed to represent excessive iron deposition. We investigated the time course of deep GM T2 hypointensity and its relationship with disability at 3 T in 8 stable relapsing-remitting (RR) MS patients treated with minocycline over 3 years. MRI and disability measurements were compared at baseline, 6, 12, 24, and 36 months. Grand mean deep GM T2 hypointensity was negatively correlated with EDSS over time (r = - 0.94, P = 0.02). This correlation was strongest in the head of caudate (r = - 0.95, P = 0.01) and putamen (r = - 0.89, P = 0.04). Additionally, baseline grand mean deep GM T2 hypointensity appears to predict third year EDSS (r = - 0.72, P = 0.04). These results suggest that iron associated deep GM injury correlates with patient disability in stable RRMS. Measurements of deep GM T2 hypointensity at high field MRI may prove to be useful in monitoring individuals with MS. Further studies are required to confirm these results in a large sample and to determine if T2 hypointensity changes in clinically active MS patients.

KW - 3 T MRI

KW - Deep gray matter

KW - Disability

KW - Iron deposition

KW - Multiple sclerosis

KW - T2 hypointensity

KW - Time course

UR - http://www.scopus.com/inward/record.url?scp=77956678638&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956678638&partnerID=8YFLogxK

U2 - 10.1016/j.jns.2010.07.014

DO - 10.1016/j.jns.2010.07.014

M3 - Article

VL - 297

SP - 76

EP - 81

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 1-2

ER -