Original language | English (US) |
---|---|
Pages (from-to) | e77-e86 |
Journal | Clinical Gastroenterology and Hepatology |
Volume | 14 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1 2016 |
ASJC Scopus subject areas
- Hepatology
- Gastroenterology
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In: Clinical Gastroenterology and Hepatology, Vol. 14, No. 7, 01.07.2016, p. e77-e86.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - 2015 James W. Freston Single Topic Conference
T2 - A Renaissance in the Understanding and Management of Irritable Bowel Syndrome
AU - Chang, Lin
AU - Heitkemper, Margaret M.
AU - Wiley, John W.
AU - Camilleri, Michael
N1 - Funding Information: Conflicts of interest These authors disclose the following conflicts: Lin Chang has served on scientific advisory boards for Takeda, AstraZeneca, Allergan, QOL Medical, Ardelyx, Synergy, Commonwealth Laboratories, Ironwood, Synthetics Biologics, and IM Health Science. John Wiley is recipient of a research grant from Takeda Pharmaceuticals. Michael Camilleri has received research support in the field of IBS in the past 3 years from Tsumura, Salix, and EnteraHealth, and he has done consulting in the field of IBS in the past 3 years with GlaxoSmithKline with remuneration to his employer, Mayo Clinic. The remaining author discloses no conflicts. Funding Information: Funding The Freston conference is supported by a Takeda endowment to the American Gastroenterological Association. Funding Information: A heritable component of IBS is supported by family and twin studies and a Swedish proband study. To date, there have been limited findings in candidate gene studies; one of the fundamental flaws has been the need for ≥2000 patients to achieve the P values of 10 -7 typically required in genetic association studies. One exception is TNFSF15 gene, which is associated with risk of IBS in several European and US cohorts. 2 The first genome-wide association study of IBS in 5466 individuals from a Swedish population-based (twin) cohort, identified 1 locus at 7p22.1, which includes the genes KDELR2 (KDEL endoplasmic reticulum protein retention receptor 2) and GRID2IP (glutamate receptor, ionotropic, delta 2 [Grid2] interacting protein), which showed consistent IBS risk effects. 3 This finding was replicated in 6 case-control cohorts from Europe and the United States. Currently, a collaborative project is examining genetics of IBS in >30,000 European population-based cohorts, and in well-characterized IBS patients and controls from Europe and the United States.
PY - 2016/7/1
Y1 - 2016/7/1
UR - http://www.scopus.com/inward/record.url?scp=84974587976&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84974587976&partnerID=8YFLogxK
U2 - 10.1016/j.cgh.2016.05.027
DO - 10.1016/j.cgh.2016.05.027
M3 - Article
C2 - 27237431
AN - SCOPUS:84974587976
SN - 1542-3565
VL - 14
SP - e77-e86
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 7
ER -