2012 Provisional classification criteria for polymyalgia rheumatica: A European League Against Rheumatism/American College of Rheumatology collaborative initiative

Bhaskar Dasgupta, Marco A. Cimmino, Hilal Maradit Kremers, Wolfgang A. Schmidt, Michael Schirmer, Carlo Salvarani, Artur Bachta, Christian Dejaco, Christina Duftner, Hanne Slott Jensen, Pierre Duhaut, Gyula Poõr, Novák Pál Kaposi, Peter Mandl, Peter V. Balint, Zsuzsa Schmidt, Annamaria Iagnocco, Carlotta Nannini, Fabrizio Cantini, Pierluigi MacChioniNicolò Pipitone, Montserrat Del Amo, Georgina Espígol-Frigolé, Maria C. Cid, Víctor M. Martínez-Taboada, Elisabeth Nordborg, Haner Direskeneli, Sibel Zehra Aydin, Khalid Ahmed, Brian Hazleman, Barbara Silverman, Colin Pease, Richard J. Wakefield, Raashid Luqmani, Andy Abril, Clement J. Michet, Ralph Marcus, Neil J. Gonter, Mehrdad Maz, Rickey E. Carter, Cynthia S. Crowson, Eric L. Matteson

Research output: Contribution to journalArticle

172 Scopus citations

Abstract

The objective of this study was to develop European League Against Rheumatism/American College of Rheumatology classification criteria for polymyalgia rheumatica (PMR). Candidate criteria were evaluated in a 6-month prospective cohort study of 125 patients with new-onset PMR and 169 non-PMR comparison subjects with conditions mimicking PMR. A scoring algorithm was developed based on morning stiffness >45 minutes (2 points), hip pain/limited range of motion (1 point), absence of rheumatoid factor and/or anti-citrullinated protein antibody (2 points), and absence of peripheral joint pain (1 point). A score ≥4 had 68% sensitivity and 78% specificity for discriminating all comparison subjects from PMR. The specificity was higher (88%) for discriminating shoulder conditions from PMR and lower (65%) for discriminating RA from PMR. Adding ultrasound, a score ≥5 had increased sensitivity to 66% and specificity to 81%. According to these provisional classification criteria, patients ≥50 years old presenting with bilateral shoulder pain, not better explained by an alternative pathology, can be classified as having PMR in the presence of morning stiffness >45 minutes, elevated C-reactive protein and/or erythrocyte sedimentation rate, and new hip pain. These criteria are not meant for diagnostic purposes.

Original languageEnglish (US)
Pages (from-to)943-954
Number of pages12
JournalArthritis and rheumatism
Volume64
Issue number4
DOIs
StatePublished - Apr 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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    Dasgupta, B., Cimmino, M. A., Kremers, H. M., Schmidt, W. A., Schirmer, M., Salvarani, C., Bachta, A., Dejaco, C., Duftner, C., Jensen, H. S., Duhaut, P., Poõr, G., Kaposi, N. P., Mandl, P., Balint, P. V., Schmidt, Z., Iagnocco, A., Nannini, C., Cantini, F., ... Matteson, E. L. (2012). 2012 Provisional classification criteria for polymyalgia rheumatica: A European League Against Rheumatism/American College of Rheumatology collaborative initiative. Arthritis and rheumatism, 64(4), 943-954. https://doi.org/10.1002/art.34356