TY - JOUR
T1 - 2-Octyl-cyanoacrylate (Dermabond), a new glue for variceal injection therapy
T2 - Results of a preliminary animal study
AU - Nguyen, Adrienne J.
AU - Baron, Todd H.
AU - Burgart, Lawrence J.
AU - Leontovich, Olga
AU - Rajan, Elizabeth
AU - Gostout, Christopher J.
PY - 2002/4
Y1 - 2002/4
N2 - Background: Endotherapy of bleeding gastric varices is problematic. The aim of this descriptive study in an animal model was to compare 2-octyl-cyanoacrylate (Dermabond), a Food and Drag Administration-approved agent for superficial wound closure, to N-butyl-2-cyanoacrylate (Histoacryl), an agent available outside of the United States for the endoscopic treatment of bleeding gastric varices. Methods: Eight New Zealand white rabbits were randomly assigned to either the study agent Dermabond or the control agent, Histoacryl. Both active agents were equally mixed with ethiodized poppy seed oil (Ethiodol) and injected into the auricular vein. The animals were euthanized at various time intervals after injection. A 2 cm strip of tissue on either side of the injection site along with the adjacent perivascular tissues were resected for histologic evaluation. Results: The use of 0.5 ml_ of Dermabond effectively induced vascular occlusion compared with 0.2 mL of Histoacryl. The histologic changes acutely and at 1 week were similar with each mixture. Conclusion: Dermabond may be useful in the treatment of gastric variceal bleeding, but further studies are necessary to determine dose response rates in animals and humans.
AB - Background: Endotherapy of bleeding gastric varices is problematic. The aim of this descriptive study in an animal model was to compare 2-octyl-cyanoacrylate (Dermabond), a Food and Drag Administration-approved agent for superficial wound closure, to N-butyl-2-cyanoacrylate (Histoacryl), an agent available outside of the United States for the endoscopic treatment of bleeding gastric varices. Methods: Eight New Zealand white rabbits were randomly assigned to either the study agent Dermabond or the control agent, Histoacryl. Both active agents were equally mixed with ethiodized poppy seed oil (Ethiodol) and injected into the auricular vein. The animals were euthanized at various time intervals after injection. A 2 cm strip of tissue on either side of the injection site along with the adjacent perivascular tissues were resected for histologic evaluation. Results: The use of 0.5 ml_ of Dermabond effectively induced vascular occlusion compared with 0.2 mL of Histoacryl. The histologic changes acutely and at 1 week were similar with each mixture. Conclusion: Dermabond may be useful in the treatment of gastric variceal bleeding, but further studies are necessary to determine dose response rates in animals and humans.
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U2 - 10.1067/mge.2002.122032
DO - 10.1067/mge.2002.122032
M3 - Article
C2 - 11923777
AN - SCOPUS:0036550334
SN - 0016-5107
VL - 55
SP - 572
EP - 575
JO - Gastrointestinal endoscopy
JF - Gastrointestinal endoscopy
IS - 4
ER -