17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus

Patricia C. Galipeau, David S. Cowan, Carissa A. Sanchez, Michael Barrett, Mary J. Emond, Douglas S. Levine, Peter S. Rabinovitch, Brian J. Reid

Research output: Contribution to journalArticle

246 Citations (Scopus)

Abstract

Increased 4N (G2/tetraploid) cell populations have been postulated to be genetically unstable intermediates in the progression to many cancers, but the mechanism by which they develop and their relationship to instability have been difficult to investigate in humans in vivo. Barrett's esophagus is an excellent model system in which to investigate the order in which genetic and cell cycle abnormalities develop relative to each other during human neoplastic progression. Neoplastic progression in Barrett's esophagus is characterized by inactivation of the p53 gene, the development of increased 4N (G2/tetraploid) cell fractions, and the appearance of aneuploid cell populations. We investigated the hypothesis that patients whose biopsies have increased 4N (G2/tetraploid) cell fractions are predisposed to progression to aneuploidy and determined the relationship between inactivation of p53 and the development of 4N abnormalities in Barrett's epithelium. Our results indicate that increased 4N (G2/tetraploid) populations predict progression to aneuploidy and that the development of 4N abnormalities is interdependent with inactivation of the p53 gene in Barrett's esophagus in vivo.

Original languageEnglish (US)
Pages (from-to)7081-7084
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume93
Issue number14
DOIs
StatePublished - Jul 9 1996
Externally publishedYes

Fingerprint

Barrett Esophagus
Tetraploidy
Loss of Heterozygosity
Aneuploidy
p53 Genes
Population
Cell Cycle
Biopsy
Neoplasms

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus. / Galipeau, Patricia C.; Cowan, David S.; Sanchez, Carissa A.; Barrett, Michael; Emond, Mary J.; Levine, Douglas S.; Rabinovitch, Peter S.; Reid, Brian J.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, No. 14, 09.07.1996, p. 7081-7084.

Research output: Contribution to journalArticle

Galipeau, Patricia C. ; Cowan, David S. ; Sanchez, Carissa A. ; Barrett, Michael ; Emond, Mary J. ; Levine, Douglas S. ; Rabinovitch, Peter S. ; Reid, Brian J. / 17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus. In: Proceedings of the National Academy of Sciences of the United States of America. 1996 ; Vol. 93, No. 14. pp. 7081-7084.
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AU - Barrett, Michael

AU - Emond, Mary J.

AU - Levine, Douglas S.

AU - Rabinovitch, Peter S.

AU - Reid, Brian J.

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