17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior

Frederik J. Steyn, Shyuan T. Ngo, Vicky Ping Chen, Lora C. Bailey-Downs, Teresa Y. Xie, Martin Ghadami, Stephen Brimijoin, Willard M. Freeman, Marcelo Rubinstein, Malcolm J. Low, Michael B. Stout

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age-related disease. We previously reported that 17α-estradiol (17α-E2) administration elicits beneficial effects on metabolism and inflammation in old male mice. These observations were associated with reduced calorie intake. Here, we demonstrate that 17α-E2 acts through pro-opiomelanocortin (Pomc) expression in the arcuate nucleus (ARC) to reduce food intake and body mass in mouse models of obesity. These results confirm that 17α-E2 modulates appetite through selective interactions within hypothalamic anorexigenic pathways. Interestingly, some peripheral markers of metabolic homeostasis were also improved in animals with near complete loss of ARC Pomc transcription. This suggests that 17α-E2 might have central and peripheral actions that can beneficially affect metabolism cooperatively or independently.

Original languageEnglish (US)
Article numbere12703
JournalAging Cell
Volume17
Issue number1
DOIs
StatePublished - Feb 1 2018

Keywords

  • 17α-estradiol
  • aging
  • food intake
  • hypothalamus
  • obesity
  • pro-opiomelanocortin

ASJC Scopus subject areas

  • Aging
  • Cell Biology

Fingerprint Dive into the research topics of '17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior'. Together they form a unique fingerprint.

Cite this