17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior

Frederik J. Steyn, Shyuan T. Ngo, Vicky Ping Chen, Lora C. Bailey-Downs, Teresa Y. Xie, Martin Ghadami, William Stephen Brimijoin, Willard M. Freeman, Marcelo Rubinstein, Malcolm J. Low, Michael B. Stout

Research output: Contribution to journalArticle

  • 2 Citations

Abstract

Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age-related disease. We previously reported that 17α-estradiol (17α-E2) administration elicits beneficial effects on metabolism and inflammation in old male mice. These observations were associated with reduced calorie intake. Here, we demonstrate that 17α-E2 acts through pro-opiomelanocortin (Pomc) expression in the arcuate nucleus (ARC) to reduce food intake and body mass in mouse models of obesity. These results confirm that 17α-E2 modulates appetite through selective interactions within hypothalamic anorexigenic pathways. Interestingly, some peripheral markers of metabolic homeostasis were also improved in animals with near complete loss of ARC Pomc transcription. This suggests that 17α-E2 might have central and peripheral actions that can beneficially affect metabolism cooperatively or independently.

LanguageEnglish (US)
Article numbere12703
JournalAging Cell
Volume17
Issue number1
DOIs
StatePublished - Feb 1 2018

Fingerprint

Pro-Opiomelanocortin
Arcuate Nucleus of Hypothalamus
Feeding Behavior
Weight Loss
Estradiol
Eating
Neurons
Appetite
Homeostasis
Obesity
Pharmacology
Inflammation

Keywords

  • 17α-estradiol
  • aging
  • food intake
  • hypothalamus
  • obesity
  • pro-opiomelanocortin

ASJC Scopus subject areas

  • Aging
  • Cell Biology

Cite this

Steyn, F. J., Ngo, S. T., Chen, V. P., Bailey-Downs, L. C., Xie, T. Y., Ghadami, M., ... Stout, M. B. (2018). 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior. Aging Cell, 17(1), [e12703]. https://doi.org/10.1111/acel.12703

17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior. / Steyn, Frederik J.; Ngo, Shyuan T.; Chen, Vicky Ping; Bailey-Downs, Lora C.; Xie, Teresa Y.; Ghadami, Martin; Brimijoin, William Stephen; Freeman, Willard M.; Rubinstein, Marcelo; Low, Malcolm J.; Stout, Michael B.

In: Aging Cell, Vol. 17, No. 1, e12703, 01.02.2018.

Research output: Contribution to journalArticle

Steyn, FJ, Ngo, ST, Chen, VP, Bailey-Downs, LC, Xie, TY, Ghadami, M, Brimijoin, WS, Freeman, WM, Rubinstein, M, Low, MJ & Stout, MB 2018, '17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior' Aging Cell, vol. 17, no. 1, e12703. https://doi.org/10.1111/acel.12703
Steyn, Frederik J. ; Ngo, Shyuan T. ; Chen, Vicky Ping ; Bailey-Downs, Lora C. ; Xie, Teresa Y. ; Ghadami, Martin ; Brimijoin, William Stephen ; Freeman, Willard M. ; Rubinstein, Marcelo ; Low, Malcolm J. ; Stout, Michael B. / 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior. In: Aging Cell. 2018 ; Vol. 17, No. 1.
@article{bedc8d293bb0440ea5e2cac52ee853a6,
title = "17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior",
abstract = "Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age-related disease. We previously reported that 17α-estradiol (17α-E2) administration elicits beneficial effects on metabolism and inflammation in old male mice. These observations were associated with reduced calorie intake. Here, we demonstrate that 17α-E2 acts through pro-opiomelanocortin (Pomc) expression in the arcuate nucleus (ARC) to reduce food intake and body mass in mouse models of obesity. These results confirm that 17α-E2 modulates appetite through selective interactions within hypothalamic anorexigenic pathways. Interestingly, some peripheral markers of metabolic homeostasis were also improved in animals with near complete loss of ARC Pomc transcription. This suggests that 17α-E2 might have central and peripheral actions that can beneficially affect metabolism cooperatively or independently.",
keywords = "17α-estradiol, aging, food intake, hypothalamus, obesity, pro-opiomelanocortin",
author = "Steyn, {Frederik J.} and Ngo, {Shyuan T.} and Chen, {Vicky Ping} and Bailey-Downs, {Lora C.} and Xie, {Teresa Y.} and Martin Ghadami and Brimijoin, {William Stephen} and Freeman, {Willard M.} and Marcelo Rubinstein and Low, {Malcolm J.} and Stout, {Michael B.}",
year = "2018",
month = "2",
day = "1",
doi = "10.1111/acel.12703",
language = "English (US)",
volume = "17",
journal = "Aging Cell",
issn = "1474-9718",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior

AU - Steyn, Frederik J.

AU - Ngo, Shyuan T.

AU - Chen, Vicky Ping

AU - Bailey-Downs, Lora C.

AU - Xie, Teresa Y.

AU - Ghadami, Martin

AU - Brimijoin, William Stephen

AU - Freeman, Willard M.

AU - Rubinstein, Marcelo

AU - Low, Malcolm J.

AU - Stout, Michael B.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age-related disease. We previously reported that 17α-estradiol (17α-E2) administration elicits beneficial effects on metabolism and inflammation in old male mice. These observations were associated with reduced calorie intake. Here, we demonstrate that 17α-E2 acts through pro-opiomelanocortin (Pomc) expression in the arcuate nucleus (ARC) to reduce food intake and body mass in mouse models of obesity. These results confirm that 17α-E2 modulates appetite through selective interactions within hypothalamic anorexigenic pathways. Interestingly, some peripheral markers of metabolic homeostasis were also improved in animals with near complete loss of ARC Pomc transcription. This suggests that 17α-E2 might have central and peripheral actions that can beneficially affect metabolism cooperatively or independently.

AB - Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age-related disease. We previously reported that 17α-estradiol (17α-E2) administration elicits beneficial effects on metabolism and inflammation in old male mice. These observations were associated with reduced calorie intake. Here, we demonstrate that 17α-E2 acts through pro-opiomelanocortin (Pomc) expression in the arcuate nucleus (ARC) to reduce food intake and body mass in mouse models of obesity. These results confirm that 17α-E2 modulates appetite through selective interactions within hypothalamic anorexigenic pathways. Interestingly, some peripheral markers of metabolic homeostasis were also improved in animals with near complete loss of ARC Pomc transcription. This suggests that 17α-E2 might have central and peripheral actions that can beneficially affect metabolism cooperatively or independently.

KW - 17α-estradiol

KW - aging

KW - food intake

KW - hypothalamus

KW - obesity

KW - pro-opiomelanocortin

UR - http://www.scopus.com/inward/record.url?scp=85040713335&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040713335&partnerID=8YFLogxK

U2 - 10.1111/acel.12703

DO - 10.1111/acel.12703

M3 - Article

VL - 17

JO - Aging Cell

T2 - Aging Cell

JF - Aging Cell

SN - 1474-9718

IS - 1

M1 - e12703

ER -