1,25-dihydroxyvitamin D3 rapidly alters the morphology of the duodenal mucosa of rachitic chicks: Evidence for novel effects of 1,25-dihydroxyvitamin D3

James T. McCarthy, Steven S. Barham, Rajiv Kumar

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

When rachitic chicks are given 1,25-dihydroxyvitamin D3 in amounts as low as 50 ng/bird, the appearance of the duodenal mucosa is altered within 2 h of the administration of the hormone. The changes are most readily apparent on scanning electron microscopy and include: a more plump appearance of villi with loss of furrows and pits on their surfaces, elongation of villi and a smoother, more uniform microvillus surface. These changes occur within 2 h of the administration of the hormone and persist for as long as 24 h. The morphological change precedes the increase in calcium absorption induced by 1,25-dihydroxyvitamin D3 in the intestine. These observations suggest that 1,25-dihydroxyvitamin D3 may play an important part in maintenance of the structure of the duodenal mucosa.

Original languageEnglish (US)
Pages (from-to)253-258
Number of pages6
JournalJournal of Steroid Biochemistry
Volume21
Issue number3
DOIs
StatePublished - Sep 1984

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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