TY - JOUR
T1 - 1,25-dihydroxyvitamin D3 rapidly alters the morphology of the duodenal mucosa of rachitic chicks
T2 - Evidence for novel effects of 1,25-dihydroxyvitamin D3
AU - McCarthy, James T.
AU - Barham, Steven S.
AU - Kumar, Rajiv
PY - 1984/9
Y1 - 1984/9
N2 - When rachitic chicks are given 1,25-dihydroxyvitamin D3 in amounts as low as 50 ng/bird, the appearance of the duodenal mucosa is altered within 2 h of the administration of the hormone. The changes are most readily apparent on scanning electron microscopy and include: a more plump appearance of villi with loss of furrows and pits on their surfaces, elongation of villi and a smoother, more uniform microvillus surface. These changes occur within 2 h of the administration of the hormone and persist for as long as 24 h. The morphological change precedes the increase in calcium absorption induced by 1,25-dihydroxyvitamin D3 in the intestine. These observations suggest that 1,25-dihydroxyvitamin D3 may play an important part in maintenance of the structure of the duodenal mucosa.
AB - When rachitic chicks are given 1,25-dihydroxyvitamin D3 in amounts as low as 50 ng/bird, the appearance of the duodenal mucosa is altered within 2 h of the administration of the hormone. The changes are most readily apparent on scanning electron microscopy and include: a more plump appearance of villi with loss of furrows and pits on their surfaces, elongation of villi and a smoother, more uniform microvillus surface. These changes occur within 2 h of the administration of the hormone and persist for as long as 24 h. The morphological change precedes the increase in calcium absorption induced by 1,25-dihydroxyvitamin D3 in the intestine. These observations suggest that 1,25-dihydroxyvitamin D3 may play an important part in maintenance of the structure of the duodenal mucosa.
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U2 - 10.1016/0022-4731(84)90277-2
DO - 10.1016/0022-4731(84)90277-2
M3 - Article
C2 - 6548536
AN - SCOPUS:0021688853
SN - 0022-4731
VL - 21
SP - 253
EP - 258
JO - Journal of Steroid Biochemistry
JF - Journal of Steroid Biochemistry
IS - 3
ER -