1,25-Dihydroxyvitamin D-mediated hypercalcemia in a renal transplant recipient

Muralikrishna S. Golconda, Tlmothy S. Larson, Llsa G. Külb, Rajiv Kumar

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Hypercalcemia occurs in 10 to 30% of renal transplant recipients and is most often due to persistent hyperparathyroidism. Herein we describe a patient with a history of hyperparathyroidism who sought medical assessment because of recurrence of hypercalcemia 7 years after a successful renal transplantation. The hypercalcemia was associated with a normal serum phosphate level, a low to normal parathyroid hormone level, virtually undetectable levels of parathyroid hormone-related protein, and increased 1,25-dihydroxyvitamin D levels. Further assessment led to the diagnosis of an underlying lymphoma. To our knowledge, this is the first report of 1,25- dihydroxyvitamin D-mediated hypercalcemia in a renal transplant recipient with lymphoma. The possibility of an underlying lymphoproliferative disorder should be considered in the differential diagnosis of hypercalcemia in a renal transplant recipient.

Original languageEnglish (US)
Pages (from-to)32-36
Number of pages5
JournalMayo Clinic Proceedings
Volume71
Issue number1
StatePublished - 1996

Fingerprint

Hypercalcemia
Kidney
Hyperparathyroidism
Lymphoma
Parathyroid Hormone-Related Protein
Lymphoproliferative Disorders
Parathyroid Hormone
Kidney Transplantation
Differential Diagnosis
Phosphates
Transplant Recipients
1,25-dihydroxyvitamin D
Recurrence
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

1,25-Dihydroxyvitamin D-mediated hypercalcemia in a renal transplant recipient. / Golconda, Muralikrishna S.; Larson, Tlmothy S.; Külb, Llsa G.; Kumar, Rajiv.

In: Mayo Clinic Proceedings, Vol. 71, No. 1, 1996, p. 32-36.

Research output: Contribution to journalArticle

Golconda, Muralikrishna S. ; Larson, Tlmothy S. ; Külb, Llsa G. ; Kumar, Rajiv. / 1,25-Dihydroxyvitamin D-mediated hypercalcemia in a renal transplant recipient. In: Mayo Clinic Proceedings. 1996 ; Vol. 71, No. 1. pp. 32-36.
@article{d3934e770bb74b6cb9b1576003f95a4e,
title = "1,25-Dihydroxyvitamin D-mediated hypercalcemia in a renal transplant recipient",
abstract = "Hypercalcemia occurs in 10 to 30{\%} of renal transplant recipients and is most often due to persistent hyperparathyroidism. Herein we describe a patient with a history of hyperparathyroidism who sought medical assessment because of recurrence of hypercalcemia 7 years after a successful renal transplantation. The hypercalcemia was associated with a normal serum phosphate level, a low to normal parathyroid hormone level, virtually undetectable levels of parathyroid hormone-related protein, and increased 1,25-dihydroxyvitamin D levels. Further assessment led to the diagnosis of an underlying lymphoma. To our knowledge, this is the first report of 1,25- dihydroxyvitamin D-mediated hypercalcemia in a renal transplant recipient with lymphoma. The possibility of an underlying lymphoproliferative disorder should be considered in the differential diagnosis of hypercalcemia in a renal transplant recipient.",
author = "Golconda, {Muralikrishna S.} and Larson, {Tlmothy S.} and K{\"u}lb, {Llsa G.} and Rajiv Kumar",
year = "1996",
language = "English (US)",
volume = "71",
pages = "32--36",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "1",

}

TY - JOUR

T1 - 1,25-Dihydroxyvitamin D-mediated hypercalcemia in a renal transplant recipient

AU - Golconda, Muralikrishna S.

AU - Larson, Tlmothy S.

AU - Külb, Llsa G.

AU - Kumar, Rajiv

PY - 1996

Y1 - 1996

N2 - Hypercalcemia occurs in 10 to 30% of renal transplant recipients and is most often due to persistent hyperparathyroidism. Herein we describe a patient with a history of hyperparathyroidism who sought medical assessment because of recurrence of hypercalcemia 7 years after a successful renal transplantation. The hypercalcemia was associated with a normal serum phosphate level, a low to normal parathyroid hormone level, virtually undetectable levels of parathyroid hormone-related protein, and increased 1,25-dihydroxyvitamin D levels. Further assessment led to the diagnosis of an underlying lymphoma. To our knowledge, this is the first report of 1,25- dihydroxyvitamin D-mediated hypercalcemia in a renal transplant recipient with lymphoma. The possibility of an underlying lymphoproliferative disorder should be considered in the differential diagnosis of hypercalcemia in a renal transplant recipient.

AB - Hypercalcemia occurs in 10 to 30% of renal transplant recipients and is most often due to persistent hyperparathyroidism. Herein we describe a patient with a history of hyperparathyroidism who sought medical assessment because of recurrence of hypercalcemia 7 years after a successful renal transplantation. The hypercalcemia was associated with a normal serum phosphate level, a low to normal parathyroid hormone level, virtually undetectable levels of parathyroid hormone-related protein, and increased 1,25-dihydroxyvitamin D levels. Further assessment led to the diagnosis of an underlying lymphoma. To our knowledge, this is the first report of 1,25- dihydroxyvitamin D-mediated hypercalcemia in a renal transplant recipient with lymphoma. The possibility of an underlying lymphoproliferative disorder should be considered in the differential diagnosis of hypercalcemia in a renal transplant recipient.

UR - http://www.scopus.com/inward/record.url?scp=0030033660&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030033660&partnerID=8YFLogxK

M3 - Article

C2 - 8538229

AN - SCOPUS:0030033660

VL - 71

SP - 32

EP - 36

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 1

ER -