1 kHz vibration stimulates ATDC5 chondrocytes

Heather Argadine, Mark Bolander, James F Greenleaf

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Low-intensity pulsed ultrasound is a commonly prescribed therapy for delayed unions and nonunions after fractures. Several clinical trials have shown that a 1.5 MHz ultrasound signal at a 200 μs tone burst repeating at 1 kHz shortens the time to normal bone strength by 30%. In vitro studies have shown that pulsed ultrasound increases aggrecan gene expression in chondrocytes. The pulsed 1.5 MHz signal produces radiation force vibration at 1 kHz. It was hypothesized that dynamic radiation force, not ultrasound, is responsible for the biological effect of the signal. Experiments showed that 1 kHz induced chondrogenesis similar to pulsed ultrasound treatment. These results have implications for stimulation of different types of strain-sensitive cells.

Original languageEnglish (US)
Title of host publicationAIP Conference Proceedings
Pages49-53
Number of pages5
Volume829
DOIs
StatePublished - May 8 2006
EventTHERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound - Boston, MA, United States
Duration: Oct 27 2005Oct 29 2005

Other

OtherTHERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound
CountryUnited States
CityBoston, MA
Period10/27/0510/29/05

Fingerprint

vibration
unions
biological effects
gene expression
radiation
stimulation
bones
therapy
bursts
cells

Keywords

  • 1 kHz
  • ATDC5
  • Chondrocyte
  • Ehondrogenesis
  • Fracture
  • Ultrasound

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Argadine, H., Bolander, M., & Greenleaf, J. F. (2006). 1 kHz vibration stimulates ATDC5 chondrocytes. In AIP Conference Proceedings (Vol. 829, pp. 49-53) https://doi.org/10.1063/1.2205436

1 kHz vibration stimulates ATDC5 chondrocytes. / Argadine, Heather; Bolander, Mark; Greenleaf, James F.

AIP Conference Proceedings. Vol. 829 2006. p. 49-53.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Argadine, H, Bolander, M & Greenleaf, JF 2006, 1 kHz vibration stimulates ATDC5 chondrocytes. in AIP Conference Proceedings. vol. 829, pp. 49-53, THERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound, Boston, MA, United States, 10/27/05. https://doi.org/10.1063/1.2205436
Argadine H, Bolander M, Greenleaf JF. 1 kHz vibration stimulates ATDC5 chondrocytes. In AIP Conference Proceedings. Vol. 829. 2006. p. 49-53 https://doi.org/10.1063/1.2205436
Argadine, Heather ; Bolander, Mark ; Greenleaf, James F. / 1 kHz vibration stimulates ATDC5 chondrocytes. AIP Conference Proceedings. Vol. 829 2006. pp. 49-53
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