@inproceedings{f5bb661dc4184e849d647e845f0116b8,
title = "1 kHz vibration stimulates ATDC5 chondrocytes",
abstract = "Low-intensity pulsed ultrasound is a commonly prescribed therapy for delayed unions and nonunions after fractures. Several clinical trials have shown that a 1.5 MHz ultrasound signal at a 200 μs tone burst repeating at 1 kHz shortens the time to normal bone strength by 30%. In vitro studies have shown that pulsed ultrasound increases aggrecan gene expression in chondrocytes. The pulsed 1.5 MHz signal produces radiation force vibration at 1 kHz. It was hypothesized that dynamic radiation force, not ultrasound, is responsible for the biological effect of the signal. Experiments showed that 1 kHz induced chondrogenesis similar to pulsed ultrasound treatment. These results have implications for stimulation of different types of strain-sensitive cells.",
keywords = "1 kHz, ATDC5, Chondrocyte, Ehondrogenesis, Fracture, Ultrasound",
author = "Heather Argadine and Mark Bolander and James Greenleaf",
year = "2006",
month = may,
day = "8",
doi = "10.1063/1.2205436",
language = "English (US)",
isbn = "073540321X",
series = "AIP Conference Proceedings",
pages = "49--53",
booktitle = "THERAPEUTIC ULTRASOUND",
note = "THERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound ; Conference date: 27-10-2005 Through 29-10-2005",
}