1 kHz low power sound stimulates ATDC5 chondrocytes

Heather M. Argadine, Randall R. Kinnick, Mark E. Bolander, James F Greenleaf

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

A current clinical product from Smith and Nephew uses a pulsed 1.5 MHz signal for treating fractures 20 minutes per day. This pulsed 1.5 MHz signal produces radiation force vibration at 1 kHz. It was hypothesized that the radiation force, not the ultrasound, is responsible for the biological effect of the Smith and Nephew system of stimulating chondrocytes. In vitro experiments using the following method indeed showed that treatment with 1 kHz induced chondrogenesis similar to treatment with 1.5 MHz pulsed ultrasound. This study provides the first evidence for 1 kHz activation of chondrocytes and for the potential mechanisms with which this vibration is sensed in the cell.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE Ultrasonics Symposium
Pages996-998
Number of pages3
Volume2
DOIs
StatePublished - 2005
Event2005 IEEE Ultrasonics Symposium - Rotterdam, Netherlands
Duration: Sep 18 2005Sep 21 2005

Other

Other2005 IEEE Ultrasonics Symposium
CountryNetherlands
CityRotterdam
Period9/18/059/21/05

Fingerprint

Ultrasonics
Acoustic waves
Radiation
Chemical activation
Experiments

Keywords

  • 1 kHz
  • ATDC5
  • Chondrocyte
  • Chondrogenesis

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Argadine, H. M., Kinnick, R. R., Bolander, M. E., & Greenleaf, J. F. (2005). 1 kHz low power sound stimulates ATDC5 chondrocytes. In Proceedings - IEEE Ultrasonics Symposium (Vol. 2, pp. 996-998). [1603018] https://doi.org/10.1109/ULTSYM.2005.1603018

1 kHz low power sound stimulates ATDC5 chondrocytes. / Argadine, Heather M.; Kinnick, Randall R.; Bolander, Mark E.; Greenleaf, James F.

Proceedings - IEEE Ultrasonics Symposium. Vol. 2 2005. p. 996-998 1603018.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Argadine, HM, Kinnick, RR, Bolander, ME & Greenleaf, JF 2005, 1 kHz low power sound stimulates ATDC5 chondrocytes. in Proceedings - IEEE Ultrasonics Symposium. vol. 2, 1603018, pp. 996-998, 2005 IEEE Ultrasonics Symposium, Rotterdam, Netherlands, 9/18/05. https://doi.org/10.1109/ULTSYM.2005.1603018
Argadine HM, Kinnick RR, Bolander ME, Greenleaf JF. 1 kHz low power sound stimulates ATDC5 chondrocytes. In Proceedings - IEEE Ultrasonics Symposium. Vol. 2. 2005. p. 996-998. 1603018 https://doi.org/10.1109/ULTSYM.2005.1603018
Argadine, Heather M. ; Kinnick, Randall R. ; Bolander, Mark E. ; Greenleaf, James F. / 1 kHz low power sound stimulates ATDC5 chondrocytes. Proceedings - IEEE Ultrasonics Symposium. Vol. 2 2005. pp. 996-998
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